Product Name:6-Paradol
CAS No.:27113-22-0
Botanical Source:Aframomum Melegueta (Seed) Extract
Assay:50% 98% powder paradol , 6-paradol
Appearance:White Fine powder
Particle Size: 100% pass 80 mesh
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
6-Paradol Product Description: A Natural Phenolic Compound with Multifaceted Bioactivities
Product Overview
6-Paradol ([6]-Gingerone) is a bioactive phenolic compound derived from ginger (Zingiber officinale) and other Zingiberaceae plants. Known for its potent biological activities, it has garnered significant attention in pharmaceutical and nutraceutical research. Its molecular formula is C₁₇H₂₆O₃ (CAS No. 27113-22-0), with a molecular weight of 278.39.
Key Bioactivities & Applications
- Anti-Cancer Effects:
- Inhibits skin carcinogenesis by binding to cyclooxygenase-2 (COX-2), a key enzyme in inflammatory pathways.
- Exhibits chemopreventive potential in preclinical models.
- Anti-Inflammatory & Neuroprotective Properties:
- Significantly reduces neuroinflammation in experimental autoimmune encephalomyelitis (EAE) models, a multiple sclerosis analog. Oral administration at 5–10 mg/kg improves clinical scores and reduces microglial activation.
- Suppresses oxidative stress and protects neuronal cells.
- Antioxidant Activity:
- Neutralizes free radicals, making it suitable for formulations targeting age-related oxidative damage.
Product Specifications
- Formats:
- Powder: 5 mg to 1 g (purity ≥95% by HPLC).
- Solvent: 1 mL × 10 mM (in DMSO), ready for in vitro studies.
- Storage:Pricing: Competitive bulk pricing available, with options for custom synthesis.
- Powder: -20°C (stable for 3 years).
- Solvent: -80°C (stable for 1 year).
Quality Assurance
- Testing Methods:Certifications: GMP-compliant production, with traceable batch documentation.
- HPLC Analysis: Validated against 6-Paradol CRS for purity verification.
- Heavy Metals: ≤10 ppm (Pb, As, Cd, Hg compliant with EU/UK standards).
- Microbial Limits: Meets pharmacopeial requirements (e.g., E. coli, Salmonella negative).
Applications in Research & Development
- Drug Discovery:
- Used in studies targeting neurodegenerative diseases (e.g., Alzheimer’s, multiple sclerosis).
- Nutraceuticals:
- Incorporated into antioxidant supplements and anti-inflammatory formulations.
- Preclinical Models:
- Effective in EAE mice (oral dose: 5–10 mg/kg/day) and ischemia-reperfusion injury models.
Why Choose Our 6-Paradol?
- Scientifically Validated: Backed by peer-reviewed studies on anti-cancer, anti-inflammatory, and neuroprotective effects.
- Regulatory Compliance: Adheres to EU/UK safety standards for food and pharmaceutical use.
- Custom Solutions: Available in research-grade and clinical-trial quantities.
Keywords: 6-Paradol, [6]-Gingerone, natural phenolic compound, anti-inflammatory, neuroprotective, COX-2 inhibitor, ginger extract, preclinical research, GMP-certified
