Product name: Piperlongumine powder
Other Name:Piplartin, Piperlongumine extract, Piplartine, 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone,PPLGM, pippali powder, Piper Longum extract
CAS Number:20069-09-4
Botanical Source:Piper Longum Linn
Assay: 98%min
Free Sample :Available
Appearance: White crystalline powder
Benefits:Anti-cancer, anti-aging,senolytic
Shelf Life: 2 years
Piperlongumine Powder | High Purity (98%+) | CAS 20069-09-4 | For Research Use
Product Overview
Piperlongumine (Piplartine), a bioactive alkaloid derived from the Piper longum plant, is a natural compound with selective anticancer properties. It effectively induces reactive oxygen species (ROS) in cancer cells, leading to apoptosis without harming normal cells, making it a promising candidate for oncology research .
Key Features
- Purity: ≥98% (HPLC verified)
- CAS Number: 20069-09-4
- Molecular Formula: C₁₇H₁₉NO₅
- Molecular Weight: 317.34 g/mol
- Appearance: White to off-white powder
- Solubility: Insoluble in water; soluble in DMSO (≥10.45 mg/mL), ethanol, and other organic solvents
- Storage: Store at -20°C in a dry, dark environment. Stable for 3 years .
Mechanism of Action
Piperlongumine selectively targets cancer cells through multiple pathways:
- ROS Induction: Elevates intracellular ROS levels, triggering oxidative stress and apoptosis in cancer cells .
- GSTP1 Inhibition: Suppresses glutathione S-transferase Pi 1 (GSTP1), disrupting redox balance in malignant cells .
- STAT3 Pathway Suppression: Inhibits STAT3 signaling, reducing tumor proliferation and survival .
- Thioredoxin Reductase (TrxR1) Inhibition: Irreversibly targets selenocysteine residues, enhancing chemosensitivity .
Research Applications
- Cancer Therapeutics:
- Induces apoptosis in breast, prostate, and myeloma cell lines (IC₅₀: 1–5 μM) .
- Synergizes with chemotherapy agents (e.g., doxorubicin, cisplatin) to overcome drug resistance .
- Signal Pathway Studies:
- Modulates NF-κB, MAPK, and JAK/STAT3 pathways .
- Neuroprotection & Aging:
- Supports neuronal health and mitigates oxidative stress in age-related models .
- Cardiovascular Research:
- Inhibits atherosclerosis by suppressing vascular smooth muscle proliferation .
Product Specifications
| Package Size | Form | Purity |
|---|---|---|
| 10 mg | Lyophilized powder | ≥98% |
| 50 mg | Lyophilized powder | ≥98% |
| Custom Bulk Orders | Available upon request |
Handling & Safety
- Reconstitution: Dissolve in DMSO for in vitro studies. For in vivo applications, use polysorbate 80 or cyclodextrin-based formulations to enhance solubility .
- Stability: Stable at pH 4–7. Avoid prolonged light exposure due to photodegradation risks .
- Safety Note: For research use only. Not intended for diagnostic or therapeutic applications .
Why Choose Our Piperlongumine?
- High-Purity Guarantee: Rigorous QC via HPLC and MSDS/COA documentation .
- Bulk Availability: Custom synthesis for large-scale research needs .
- Global Compliance: Meets international standards for reagent-grade chemicals.
References
- Selective anticancer activity via ROS induction .
- Enhanced efficacy in combination therapies .
- Solubility and stability profiles .
Keywords: Piperlongumine powder, anticancer research, ROS induction, STAT3 inhibitor, high-purity alkaloid.
