Reduced nicotinamide riboside(NRH)
CAS No:19132-12-8
Specifications: 98.0%
Colour: White to off-white powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Product Description: Reduced Nicotinamide Riboside (NRH) – The Ultimate NAD+ Booster for Cellular Vitality
Introduction
Reduced Nicotinamide Riboside (NRH) is a cutting-edge, bioactive form of vitamin B3, renowned for its unparalleled ability to elevate cellular NAD+ levels—a critical coenzyme for energy metabolism, DNA repair, and anti-aging processes. Backed by robust scientific research, NRH outperforms traditional NAD+ precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), offering rapid and sustained benefits for health-conscious consumers.
Key Advantages
- Superior NAD+ Enhancement
- NRH boosts intracellular NAD+ levels 2.5–10 times faster than NR or NMN, achieving significant results within 1 hour of ingestion.
- Unlike NR, which requires phosphorylation for activation, NRH directly converts to NAD+ via a single enzymatic step, bypassing metabolic bottlenecks.
- Enhanced Bioavailability & Stability
- NRH demonstrates 95% oral bioavailability, ensuring efficient absorption and cellular uptake.
- Synthesized under strict anaerobic conditions and purified via column chromatography, NRH maintains 96% purity with minimal degradation.
- Stable in alkaline pH (8.1–9.0) and protected from light/moisture, ensuring long-term efficacy in supplements.
- Diverse Health Benefits
- Anti-Aging & Cellular Repair: Supports sirtuin and PARP activity to enhance DNA repair and combat oxidative stress.
- Metabolic & Cognitive Health: Improves mitochondrial function, reduces fatigue, and protects against age-related cognitive decline.
- Organ Protection: Clinically shown to mitigate kidney injury from toxins (e.g., cisplatin) and enhance resistance to cellular damage.
Mechanism of Action
NRH acts as a reduced NAD+ precursor, donating electrons to regenerate NAD+ pools. It operates independently of the NR pathway, utilizing unique enzymes like adenosine kinase and NMNAT for rapid conversion. This distinct mechanism avoids competition with other B3 derivatives, ensuring maximal NAD+ synthesis even under stress conditions.
Applications
- Dietary Supplements: Ideal for anti-aging formulations, energy boosters, and cognitive health products.
- Cosmeceuticals: Enhances skin resilience by promoting collagen synthesis and reducing oxidative damage.
- Pharmaceutical Research: Investigated for neuroprotection, metabolic syndrome, and chemoprotection.
Recommended Usage
- Dosage: 50–250 mg daily, depending on formulation (capsules, powders, or liposomal delivery).
- Safety: No adverse effects observed at recommended doses. Contraindicated in specific cancer models (e.g., HepG3 cells) due to cell-specific metabolic vulnerabilities.
Storage & Stability
- Store in airtight, light-resistant containers at 4°C or below.
- Degrades rapidly in acidic environments or oxygen exposure—formulate with alkaline buffers (pH >8) for optimal shelf life.
Scientific Validation & Compliance
- Supported by peer-reviewed studies in Cell Metabolism and Nature Communications.
- Complies with EU Novel Food Regulations (No. 2017/2470) for safety and purity.
- Manufactured under ISO-certified conditions, with HPLC and NMR verification for batch consistency.
Why Choose NRH?
For consumers seeking a science-backed, high-performance NAD+ booster, NRH offers unmatched efficiency and versatility. Whether targeting longevity, energy, or metabolic health, NRH is the next-generation solution for optimizing cellular vitality.
Keywords: NAD+ booster, anti-aging supplement, cellular energy, mitochondrial health, vitamin B3 derivative, scientific-grade NRH.
