S-adenosyl-L-methionine disulfate tosylate

Product Name:S-adenosyl-L-methionine disulfate tosylate

Other Name:Ademetionine disulfate tosylate; AdeMethionine Disulfate Tosylate; SAM-TAdemetionine disulfate tosylate; Ademetionine Disulfate Tosylate(SAMe)

CAS No:97540-22-2

Assay:  98%Min

Colour: White fine Powder

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production
Product Description: S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe-DT)

Product Description: S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe-DT)

Product Overview

S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe-DT), CAS 97540-22-2, is a hygroscopic, white to off-white powder, odorless, and freely soluble in water . With the molecular formula C₂₂H₃₄N₆O₁₆S₄ and a molecular weight of 766.8, it serves as a primary methyl donor in mammalian cells, particularly abundant in the liver . This compound is widely utilized in pharmaceuticals, dietary supplements, and biochemical research due to its role in methylation, sulfhydryl transfer, and aminopropylation processes .

Key Features & Applications

1. Biological Functions:
   • Methylation: Critical for DNA/RNA synthesis, protein modification, and epigenetic regulation .
   • Liver Protection: Enhances glutathione production, detoxifies harmful substances, and supports liver health in conditions like cirrhosis .
   • Joint Health: Promotes cartilage repair, alleviates osteoarthritis symptoms (pain, stiffness) .
   • Neurological Benefits: Modulates neurotransmitters (e.g., serotonin, dopamine), aiding mood regulation and depression management .
2. Applications:
   • Pharmaceuticals: Used in treating liver diseases, osteoarthritis, and neurological disorders .
   • Dietary Supplements: Marketed in enteric-coated tablets (200–400 mg/serving) for liver support and joint health .
   • Research: Applied in studies on cancer (anti-proliferative effects), aging (telomere stabilization), and metabolic pathways .

Physical & Chemical Properties

• Appearance: White to off-white powder .
• Solubility: Freely soluble in water (~10 mg/mL in PBS pH 7.2); soluble in DMSO, ethanol, and DMF .
• Storage: Store at 2–8°C in airtight, light-protected containers. Hygroscopic—avoid moisture .
• Purity: ≥95% (HPLC), with ≤1% moisture content and ≤10 ppm heavy metals .

Safety & Compliance

• Hazard Classification: Corrosive to skin/eyes, respiratory irritant (GHS). Use PPE (gloves, goggles) and work in ventilated areas .
• Regulatory Status:Warning: For research use only. Not approved for human/veterinary therapeutic use .
  • FDA-reviewed for dietary use (up to 300–1600 mg/day) under NDIN .
  • Complies with USP standards (USP 1012134) for pharmaceutical quality .
  • Transported under IMDG/DOT/IATA regulations .

Packaging & Ordering

• Formats: 10 mM solutions (in DMSO), 100 mg–500 mg powder .
• Packaging: 25 kg/drum or customized options. Cold shipping recommended .
• Suppliers: Available from certified manufacturers (e.g., GSHWORLD, China) with ISO/GMP certifications .

Keywords

Methyl donor, SAMe supplement, liver protection, osteoarthritis relief, mood enhancement, USP-certified, CAS 97540-22-2, research-grade SAMe-DT.