Title: Premium Smoke Tree Extract 98% Fisetin by HPLC | Natural Antioxidant & Anti-Aging Supplement
Keywords: Fisetin 98%, HPLC Verified, Smoke Tree Extract, Natural Antioxidant, Anti-Aging Supplement
1. Product Overview
Smoke Tree Extract 98% Fisetin is a high-purity natural compound derived from Cotinus coggygria (Smoke Tree), standardized to 98% Fisetin through advanced High-Performance Liquid Chromatography (HPLC) technology. Fisetin (C₁₅H₁₀O₆) is a flavonoid renowned for its potent antioxidant, anti-inflammatory, and senolytic properties, making it a sought-after ingredient in nutraceuticals, cosmetics, and pharmaceutical formulations .
2. Key Specifications
- Active Ingredient: Fisetin ≥98% (HPLC)
- CAS No.: 528-48-3
- Molecular Formula: C₁₅H₁₀O₆
- Appearance: Bright yellow powder
- Solubility: Soluble in ethanol, DMSO; slightly soluble in water
- Plant Source: Cotinus coggygria leaves and stems
- Certifications: GMP, ISO 9001, COA (Certificate of Analysis) provided
3. Production Process & Quality Control
3.1 Sustainable Extraction
We employ supercritical CO₂ extraction to ensure eco-friendly and solvent-free isolation of Fisetin, preserving its bioactive integrity.
3.2 HPLC Purification & Verification
- Chromatographic Conditions:
- Column: ZORBAX C18 (4.6×150 mm, 5 μm)
- Mobile Phase: Gradient elution with 5% acetic acid (Solvent A) and acetonitrile (Solvent B)
- Detection: UV absorbance at 360 nm, retention time ≈11.6–12.6 min (consistent with Fisetin standard)
- Mass Spectrometry (MS):
- Positive Ion Mode: m/z 287.05487 (C₁₅H₁₁O₆⁺)
- Negative Ion Mode: m/z 285.03997 (C₁₅H₉O₆⁻)
- Fragmentation Patterns: Matched with authentic Fisetin standards to confirm molecular structure .
3.3 Stability Assurance
Fisetin is sensitive to light and heat. Our product is packaged in UV-protected amber glass with desiccants to ensure stability during storage and transportation .
4. Applications & Benefits
4.1 Anti-Aging & Senescence
Fisetin acts as a senolytic agent, selectively eliminating senescent cells linked to age-related diseases. Studies show it enhances lifespan in models by activating SIRT1 pathways .
4.2 Neuroprotection
Crosses the blood-brain barrier to reduce oxidative stress, potentially mitigating Alzheimer’s and Parkinson’s progression .
4.3 Anti-Inflammatory & Cancer Research
Modulates NF-κB and COX-2 pathways, inhibiting pro-inflammatory cytokines. Preclinical data suggest apoptosis induction in cancer cells .
4.4 Cosmeceuticals
Topical formulations improve skin elasticity and reduce UV-induced damage by neutralizing free radicals .
5. Compliance & Safety
- Toxicity Data: LD₅₀ >2000 mg/kg (oral, rat), classified as non-toxic.
- Regulatory Compliance: Meets USP, EP, and FDA guidelines for dietary supplements.
- Allergen-Free: Non-GMO, gluten-free, and vegan-friendly.
6. Packaging & Ordering
- Available Sizes: 25 kg/drum (bulk), 1 kg (sample)
- MOQ: 1 kg (samples); 25 kg for bulk orders.
- Global Shipping: DHL/FedEx with cold chain options for temperature-sensitive regions.
7. FAQs
Q: How is purity verified?
A: Each batch undergoes dual testing via HPLC and MS, with COA provided .
Q: Can fisetin replace quercetin?
A: While both are flavonoids, fisetin exhibits superior bioavailability and senolytic effects .
Q: Shelf life?
A: 24 months when stored at ≤25°C in sealed, light-resistant containers.
8. Why Choose Us?
- R&D Expertise: Leveraging biosynthesis pathways (e.g., P450 monooxygenase optimization) for higher yield .
- Customization: Adjustable purity (50%~98%) and OEM services available .
- Sustainability: Ethanol-water extraction aligns with green chemistry principles .
9. References
- Assembly of a Novel Biosynthetic Pathway for Fisetin Production (2024) .
- HPLC Analysis of Flavonoids in Sophora japonica (Yang et al., 2017) .
- A. integrifolia Extract Profiling (Biomedical Science Letters, 2020)
