Muna 1913, musayendisiti wekuSweden Muzvinafundo Kylin akawana chinonamira chinotsvedza chekelp, fucoidan, paUppsala University.Iyo inozivikanwawo se "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", nezvimwewo, zita rechirungu ndi "Fucoidan".Icho chinhu chinonyungudika nemvura polysaccharide inoumbwa nefucose ine sulfate mapoka.Iyo inonyanya kuvepo muvhu slime yebrown algae (yakaita segungwa, wakame spores, uye kelp).Zviri mukati zvinenge 0.1%, uye zvirimo mukelp yakaoma zvinenge 1%.Icho chinhu chakakosha zvikuru chegungwa chinoshanda.
Kutanga, kushanda kwefucoidan
Parizvino Japan ndiyo nyika ine hupenyu hurefu kupfuura mamwe pasi rose.Panguva imwecheteyo, Japan ine imwe yemazinga akaderera ezvirwere zvisingaperi.Maererano nevanovaka muviri, chimwe chezvikonzero zvakakosha zvehutano hwevanhu veJapan chinogona kunge chine chekuita nekugara uchinwa chikafu chegungwa.Fucoidan iri mubrown algae senge kelp chinhu chinoshanda chine mabasa akasiyana emuviri.Kunyangwe yakawanikwa naProfessor Kylin mu1913, haina kusvika 1996 iyo Fucoidan yakabudiswa pa55th Japanese Cancer Society Conference.Chirevo chekuti "chinogona kukonzeresa cancer cell apoptosis" chamutsa kushushikana kwakapararira munharaunda yezvidzidzo uye kwakakonzera kuwedzera mukutsvagisa.
Parizvino, nharaunda yezvokurapa iri kuita tsvakiridzo pamusoro peakasiyana siyana biological mabasa efucoidan, uye yakaburitsa zviuru zvemapepa mumagazini ezvekurapa epasi rese, ichisimbisa kuti fucoidan ine akasiyana biological mabasa, akadai anti-tumor, kuvandudza gastrointestinal turakiti, uye antioxidant, Enhance immune immune. , antithrombotic, kuderera kweropa, antiviral madhara.
(I) Fucoidan inovandudza gastrointestinal efficacy
Helicobacter pylori ihelical, microaerobic, gram-negative bacilli iyo iri kudiwa zvakanyanya pakukura kwemamiriro.Ndiwo ega marudzi eutachiona parizvino anozivikanwa kurarama mudumbu remunhu.Helicobacter pylori chirwere chinokonzera gastritis uye dumbu rekudya.Zvironda, lymphoproliferative gastric lymphomas, nezvimwewo, vane fungidziro yakaipa yegomarara remudumbu.
Nzira dzepathogenic dzeH. pylori dzinosanganisira: (1) kunamatira: H. pylori inogona kupfuura semuchuru uye inonamatira kune gastric epithelial cells;(2) kuita neutralize gastric acid kuti irarame: H. pylori inobudisa urease, uye Urea mudumbu inopindirana kuti ibudise ammonia gas, iyo inoderedza gastric acid;(3) inoparadza gastric mucosa: Helicobacter pylori inobudisa VacA toxin uye inoparadza masero epamusoro egastric mucosa;(4) inogadzira muchetura chloramine: ammonia gasi rinoparadza zvakananga gastric mucosa, uye reactive oxygen Mhedzisiro yacho inobudisa imwe muchetura chloramine;(5) Inokonzera mhinduro yekuputika: Kuti udzivirire kuHelicobacter pylori, nhamba huru yemasero machena eropa anoungana pagastric mucosa kuti abudise mhinduro yekuputika.
Migumisiro yefucoidan inopesana neHelicobacter pylori inosanganisira:
1. Kudzivirirwa kweHelicobacter pylori kuwanda;
Muna 2014, chikwata chetsvakurudzo cheYun-Bae Kim paChungbuk National University muSouth Korea chakaburitsa chidzidzo chinoratidza kuti fucoidan ine antibacterial effect yakanaka kwazvo, uye fucoidan iri muchikamu che100µg/mL inogona kumisa zvachose kuwanda kweH. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Kudzivirira kunamatira uye kupinda kweHelicobacter pylori;
Fucoidan ine sulfate mapoka uye inogona kusunga kuHelicobacter pylori kudzivirira kuti isanamatira kugastric epithelial cells.Panguva imwecheteyo, Fucoidan inogona kurambidza kugadzirwa kwe urease uye kudzivirira iyo acidic nharaunda yemudumbu.
3. Antioxidant effect, kuderedza kugadzirwa kwechepfu;
Fucoidan yakanaka antioxidant, inogona kukurumidza kutsvaira okisijeni isina radicals uye kuderedza kugadzirwa kweinokuvadza toxin chloramine.
4. Anti-inflammatory effect.
Fucoidan inogona kuvharidzira basa rekusarudza lectin, kuzadzisa uye heparanase, uye kuderedza kuzvimba mhinduro.(Helicobacter, 2015, 20, 89–97.)
Mukuwedzera, vatsvakurudzi vakawana kuti fucoidan ine simba guru pakuvandudza hutano hwematumbo uye ine nzira mbiri dzekugadzirisa mudumbu: kunatsiridza kuvimbiswa uye enteritis.
Muna 2017, timu yekutsvagisa kubva kuna Muzvinafundo Ryuji Takeda weKansai University yeWelfare Sayenzi muJapan yakaita ongororo.Vakasarudza varwere makumi matatu vane kuvimbiswa uye vakakamura kuva mapoka maviri.Boka rekuyedza rakapihwa 1 g yefucoidan uye boka rekutonga rakapihwa placebo.Mwedzi miviri mushure mekuedzwa, zvakaonekwa kuti nhamba yemazuva ekuita tsvina pavhiki muboka rekuedza kutora fucoidan yakawedzera kubva paavhareji yemazuva 2.7 kusvika kumazuva 4.6, uye vhoriyamu yetsvina uye kupfava kwakawedzera zvakanyanya.(Functional Foods in Health and Disease 2017, 7: 735-742.)
Muna 2015, boka raProfessor Nuri Gueven weYunivhesiti yeTasmania, Australia, rakaona kuti fucoidan inogona kunyatsovandudza enteritis mumakonzo, kune rumwe rutivi, inogona kubatsira mbeva kudzorera uremu uye kuwedzera kuoma kwe defecation;kune rumwe rutivi, inogona kuderedza uremu hwekoloni uye spleen.Inoderedza kuzvimba mumuviri.(PLoS ONE 2015, 10: e0128453.)
B) Antitumor mhedzisiro yefucoidan
Tsvagiridzo pamusoro peiyo antitumor mhedzisiro yefucoidan parizvino ndiyo inonyanya kunetseka nemadenderedzwa ezvidzidzo, uye mizhinji yetsvagiridzo yakawanikwa.
1. Kudzorwa kwe tumor cell cycle
Muna 2015, Muzvinafundo Lee Sang Hun nevamwe paSoonchunhyang University kuSouth Korea nevamwe vaongorori vakawana kuti fucoidan inhibits kutaura kwecyclin Cyclin uye cyclin kinase CDK muma tumor cell nekudzora kutenderera kwekukura kwemaseru egomarara remunhu, zvichikanganisa yakajairika mitosis. bundu masero.Stagnate tumor cell mu pre-mitotic phase uye inhibit tumor cell kuwanda.(Molecular Medicine Reports, 2015, 12, 3446.)
2.Induction ye tumor cell apoptosis
Muna 2012, chidzidzo chakaburitswa nechikwata cheQuan Li chekutsvagisa paQingdao University chakawana kuti fucoidan inogona kumisikidza apoptosis chiratidzo che tumor cell-Bax apoptosis protein, inokonzeresa kukuvadzwa kweDNA kumasero egomarara rezamu, kuunganidzwa kwechromosome, uye kukonzeresa apoptosis yemamota maseru., Yakadzivisa kukura kwebundu masero mumakonzo.(Plos One, 2012, 7, e43483.)
3.Inhibit tumor cell metastasis
Muna 2015, Chang-Jer Wu nevamwe vatsvakurudzi veNational Taiwan Ocean University vakabudisa tsvakurudzo inoratidza kuti fucoidan inogona kuwedzera tishu inhibitory factor (TIMP) kutaura uye pasi-regulate matrix metalloproteinase (MMP) kutaura, nokudaro inhibiting tumor cell metastasis.(Mar. Zvinodhaka 2015, 13, 1882.)
4.Inhibit bundu angiogenesis
Muna 2015, boka rekutsvagisa reTz-Chong Chou kuTaiwan Medical Center rakaona kuti fucoidan inogona kuderedza kugadzirwa kwevascular endothelial growth factor (VEGF), inhibit the neovascularization yemamota, kubvisa chikafu chinovaka muviri, kuita nzara kumamota. hukuru hukuru Vhara kupararira uye metastasis ye tumor cell.(Mar. Zvinodhaka 2015, 13, 4436.)
5.Activate immune system yemuviri
Muna 2006, Muzvinafundo Takahisa Nakano weKitasatouniversity University kuJapan akawana kuti fucoidan inogona kuwedzera kudzivirirwa kwemuviri uye kushandisa immune system yemurwere kuuraya maseru egomarara.Mushure mokunge fucoidan inopinda mumatumbo emukati, inogona kuonekwa nemasero ekudzivirira muviri, inogadzira zviratidzo zvinomutsa immune system, uye inomutsa NK masero, B masero, uye T masero, nokudaro achigadzira masoja anosunga masero ekenza uye T masero anouraya kenza. masero.Kuuraya chaiko kwemasero egomarara, kuvharisa cancer cell kukura.(Planta Medica, 2006, 72, 1415.)
Kugadzirwa kweFucoidan
Izvo zviri mumapoka e sulfate mune molecule yefucoidan chiratidzo chakakosha chinotarisa chiitiko chayo chemuviri, uye zvakare chinhu chakakosha chechimiro-chiitwa hukama hwefucoidan.Naizvozvo, zviri mukati meboka re sulfate yakakosha parameter yekuongorora fucoidan mhando uye chimiro-chiitwa hukama.
Nguva pfupi yadarika, rezenisi rekugadzira chikafu chefucoidan polysaccharide rakazopihwa chitupa neChikafu neDrug Administration ndokupihwa Qingdao Mingyue Seaweed Group, zvinoreva kuti Mingyue Seaweed Group yanga ichirima gungwa zvakanyanya kwemakore anopfuura makumi mashanu.Tora chitupa chepamutemo.Zvinonzi Mingyue Seaweed Group yakavaka tambo yekugadzira fucoidan ine gore negore kubuda kwematani gumi.Mune ramangwana, ichapa kutamba kwakazara kune yayo "mushonga uye chikafu homology" mhedzisiro uye kupenya mumunda wekudya unoshanda weindasitiri hombe yehutano.
Mingyue Seaweed Boka, sebhizinesi rakatenderwa kugadzirwa kwefucoidan chikafu, ine makore mazhinji ehunyanzvi hwekugadzira.Iyo fucoidan inogadzirwa nayo inyanzvi yekusimudzira chigadzirwa chepakutanga kelp concentrate / poda.Kushandisa chemhando yepamusoro chikafu-giredhi brown algae seyakabikwa, kuenderera mberi kucheneswa uye kupatsanurwa kunoenderana neakasikwa tekinoroji, haingogadzirise kunaka uye kuravira kwechigadzirwa, asiwo inowedzera iyo fucoidan polysaccharide yemukati (kuchena), inogona kushandiswa mukati. minda yakawanda senge chikafu chinoshanda uye chikafu chehutano..Iine zvakanakira kuchena kwechigadzirwa chepamusoro uye zvinyorwa zvepamusoro zvemapoka anoshanda;kubviswa kwesimbi inorema, kuchengetedzwa kwepamusoro;desalination uye hove, kuravira uye kuravira kunatsiridza.
Kushandiswa kweFucoidan
Parizvino, kune akawanda fucoidan zvigadzirwa zvakagadziridzwa uye kuiswa muJapan, South Korea, United States nedzimwe nyika, senge yakawedzera concentrated fucoidan, fucoidan inobvisa macapsules mambishi, uye mafuta egungwa super fucoidan.Zvikafu zvinoshanda seSeaweed Group's Qingyou Le, Rockweed Treasure, Brown Algae Plant Beverage.
Mumakore achangopfuura, "Chirevo pamusoro peChimiro cheChina Vagari 'Nutrition uye Chirwere Chisingaperi" chinoratidza kuti chimiro chekudya chevagari vekuChina chachinja, uye kuwanda kwezvirwere zvisingaperi kuri kuwedzera.Mapurojekiti makuru ehutano akanangana ne "kurapa zvirwere" akakwezva vanhu vazhinji.Kushandisa fucoidan kugadzira uye kugadzira chikafu chinoshanda chinoongorora zvizere kukosha kunobatsira kwefucoidan kupa hupenyu uye hutano, izvo zvakakosha pakuvandudzwa kwe "mushonga une hutano uye chikafu homology" indasitiri yakakura yehutano.
Chigadzirwa Link: https://www.trbextract.com/1926.html
Nguva yekutumira: Mar-24-2020