Iyo Covid-19, kana imwe inozivikanwa se2019-nCoV kana SARS-CoV-2 hutachiona, ndeyemhuri yeCoronavirus.Sezvo SARS-CoV-2 iri yeiyo β genus Coronavirus ine hukama zvakanyanya neMERS-CoV neSARS-CoV - iyo inonzi zvakare yakakonzera zviratidzo zvakakomba zvepneumonia mumadenda apfuura.Iyo genetic chimiro che2019-nCoV chave chakamisikidzwa uye chakaburitswa.[i] [ii] Mapuroteni makuru muhutachiona uhu uye ayo akamboonekwa muSARS-CoV kana MERS-CoV anoratidza kufanana kwakanyanya pakati pavo.
Hunhu hutsva hwehutachiwana uhwu hunoreva kuti kune kwakawanda kusavimbika kwakatenderedza hunhu hwahwo, saka kwave kutanga kuona kuti zvinomera zvemakwenzi kana makomisheni zvinogona kubatsira munharaunda seprophylactic agents kana sezvinhu zvakakodzera mumishonga inorwisa-coronavirus kurwisa Covid. -19.Nekudaro, nekuda kweiyo Covid-19 yakanyanya kufanana neyakambotaurwa SARS-CoV uye MERS-CoV hutachiona, yakamboburitswa tsvakiridzo pamusoro pemishonga yemakwenzi, iyo yakaratidza kuti ine anti-coronavirus mhedzisiro, inogona kunge iri gwara rakakosha rekutsvaga anti-coronavirus. zvirimwa zvemakwenzi, izvo zvinogona kunge zvichishanda kurwisa hutachiona hweSARS-CoV-2.
Mushure mekuputika kweSARS-CoV, yakatanga kutaurwa kutanga kwa2003[iii], masayendisiti anga achiedza zvine simba kushandisa akati wandei antiviral makomisheni kurwisa SARS-CoV.Izvi zvanga zvaita kuti boka renyanzvi muChina riongorore zvinopfuura mazana maviri eChinese mishonga yemakwenzi emishonga yemishonga inorwisa mavhairasi kurwisa chirwere ichi.
Pakati peizvi, zvinyorwa zvina zvakaratidza zvine mwero kusvika kune zvine simba inhibition mhedzisiro kurwisa SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (Sweet wormwood) uye Lindera aggregate (inonhuwirira evergreen shrub nhengo yemhuri yelaurel. )Iwo antiviral mhedzisiro yeaya aienderana nedosi uye aibva kubva pakadzika kuwanda kweiyo yakatorwa kusvika kumusoro, ichisiyana kune yega yega yemishonga inotorwa.Kunyanya Lycoris radiata yairatidza yakanyanya simba anti-utachiona chiitiko kurwisa hutachiona.
Mhedzisiro iyi yaienderana neiyo yemamwe mapoka maviri ekutsvagisa, ayo aikurudzira kuti inoshanda inoumbwa muLicorice midzi, Glycyrrhizin, yakaratidza kuve ine anti-SARS-CoV chiitiko nekudzivisa kudzokorora kwayo.[v] [vi] Mune imwe kudzidza, Glycyrrhizin yakaratidzawo antiviral chiitiko payakayedzerwa yayo in vitro antiviral mhedzisiro pagumi akasiyana ekiriniki ega eSARS coronavirus.Baicalin - chikamu chechirimwa Scuttelaria baicalensis (Skullcap) - yakaedzwawo muchidzidzo ichi pasi pemamiriro akafanana uye yakaratidzawo antiviral chiito kurwisa coronavirus yeSARS.[vii] Baicalin yakaratidzawo kurambidza kudzokororwa kweHIV. -1 virus in vitro muzvidzidzo zvakapfuura.[viii] [ix] Zvakadaro zvinofanirwa kucherechedzwa kuti in vitro zvakawanikwa zvinogona kusaenderana ne in vivo kiriniki efficacy.Izvi zvinodaro nekuti iyo yemuromo dosi yeaya maajenti muvanhu anogona kusakwanisa kuwana ropa serum concentration yakafanana neyakaedzwa in vitro.
Lycorine yakaratidzawo simba rekurwisa hutachiona hweSARS-CoV.3 Mishumo yakati wandei yapfuura inoratidza kuti Lycorine inoita kunge ine mabasa ekurwisa hutachiona uye inonzi yakaratidza chiito chekudzivisa paHerpes Simplex virus (type I)[x] uye Poliomyelitis. utachiona zvakare.[xi]
"Mimwe mishonga inonzi yakaratidza antiviral kuita kurwisa SARS-CoV iLonicera japonica (yeJapan Honeysuckle) uye inowanzozivikanwa Eucalyptus chirimwa, uye Panax ginseng (mudzi) kuburikidza nechinhu chinoshanda cheGinsenoside-Rb1."[xii]
Humbowo kubva muzvidzidzo zvadudzwa pamusoro uye dzimwe dzinoverengeka dzepasirese zvidzidzo zvinoshuma kuti mishonga yemakwenzi yakawanda yakaratidza mabasa ekurwisa hutachiona hwekoronavirus[xiii] [xiv] uye maitiro avo makuru anoita senge ari kuburikidza nekudzivirirwa kwehutachiona kudzokorora.[xv] China akashandisa zvakanyanya mishonga yechinyakare yekuChina kurapa SARS zvinobudirira mune dzakawanda zviitiko.[xvi] Zvisineyi hapasati paine humbowo hukuru pakushanda kwekiriniki kweizvi kune varwere vane Covid-19.
Zvingave zvakatorwa zvemuriwo zvingave vangangove vari kukwikwidza mukugadzirwa kwemishonga mitsva yekudzivirira nekudzivirira kana kurapwa kweSARS?
DZIDZISO: Chinyorwa ichi chakanyorerwa ruzivo chete uye hachina kuitirwa kutsiva zano rechiremba, kuongororwa kana kurapwa.Kana iwe uchifunga kuti ungave uine zviratidzo zvine chekuita nezve Covid-19 kana chero chimwe chirwere, fonera chiremba wako nekukurumidza.
[I] Zhou, P., Yang, X., Wang, X. et al., 2020. Kubuda kwepneumonia kwakabatana nekoronavirus itsva yekwakabva bat.Zvisikwa 579, 270–273 (2020).https://doi.org/10.1038/s41586-020-2012-7
[Ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC naGarry, RF, 2020. Mabviro akareba eSARS-CoV-2.Nature Medicine, p.1-3.
[iii] CDC SARS Mhinduro yenguva.Inowanikwa pa https://www.cdc.gov/about/history/sars/timeline.htm.Accessed
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG uye Li, RS 2005Antiviral research, 67(1), p.18-23.
[v] Cinatl, J., Morgenstem, B. uye Bauer, G., 2003. Glycyrrhizin, chikamu chinoshanda che licorice midzi uye kudzokorora kweSARS-yakabatana coronovirus.Lancet, 361(9374), pp.2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW uye Cinatl, J., 2005. Antiviral Activity yeGlycyrrhizic Acid Derivatives against SARS− Coronavirus.Nyaya yemishonga yemakemikari, 48 (4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW naGuan, Y., 2004. In vitro susceptibility yemakiriniki gumi ega ega eSARS coronavirus kune akasarudzwa antiviral makomisheni.Nyaya yeClinical Virology, 31 (1), mapeji 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. and Tokunaga, T., 1998. Baicalin, an inhibitor of HIV-1 kugadzirwa in vitro.Antiviral research, 37(2), p.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW naWang, JM, 2000. Flavonoid baicalin inhibits HIV-1 utachiona pamwero wehutachiona hwekupinda.Biochemical uye biophysical research communications, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. uye Kobayashi, S., 1989. Mhedzisiro yealkaloids yakaparadzaniswa kubva kuAmaryllidaceae pa herpes simplex virus.Tsvagiridzo muvirology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. uye Alderweireldt, F., 1982. Plant antiviral agents.III.Kuparadzaniswa kwealkaloids kubva kuClivia miniata Regel (Amaryl-lidaceae).Chinyorwa cheZvakasikwa Zvigadzirwa, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. uye Liang, FS, 2004 .Madiki mamorekuru anonangana neakakomba acute respiratory syndrome yemunhu.Nyaya dzeNational Academy of Sciences, 101 (27), pp.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS naHou, CC, 2007. Zvakananga chirimwa terpenoids uye lignoids vane ane simba antiviral zviitiko kurwisa yakanyanya acute respiratory syndrome coronavirus.Nyaya yemishonga yemakemikari, 50 (17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW uye Towers, GHN, 1995. Antiviral screening yeBritish Columbian mishonga yemiti.Nyaya yeEthnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA naNaji, MA, 2003. Novel antiviral agents: maonero echirimwa chemishonga.Journal of Apped microbiology, 95 (3), pp.412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. uye Liu, JP, 2020. Mushonga weChinese unogona kushandiswa kudzivirira chirwere chekoronavirus 2019 (COVID -19)?Ongororo yezvakaitika kare, humbowo hwekutsvaga uye zvirongwa zvekudzivirira zvazvino.Chinese Journal of Integrative Medicine, pp.1-8.
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Nguva yekutumira: Kubvumbi-18-2020