Pyrroloquinoline quinone (PQQ), antioxidant inowanikwa muzvikafu zvakaita se kiwifruit, yakawanikwa ichipa mabhenefiti kuhutano hwemapfupa muongororo yapfuura, kusanganisira ongororo dzinoratidza kuti inhibits osteoclastic bone resorption (osteoclastogenesis) uye inosimudzira osteoblastic bone formation (osteoblastogenesis).Asi mitsva yezvidzidzo zvemhuka yakawana, kekutanga, kuti chigadziro chinogona kudzivirira osteoporosis inokonzerwa nekushaya testosterone.
Kunyange zvazvo osteoporosis yakabatanidzwa nekuenda kumwedzi inyaya yehutano inonyatsozivikanwa muvakadzi, testosterone inoshaya-induced osteoporosis muvarume yakanyatsoonekwa kuti yakabatana nehurwere hukuru uye huwandu hwekufa mushure mekuputsika kwe osteoporotic fractures, kunyange zvazvo inowanzoitika gare gare muupenyu kupfuura postmenopausal osteoporosis. muvakadzi.Nekudaro, kusvika zvino, vaongorori vanga vasati vaongorora kana PQQ inogona kuvandudza osteoporosis yakabatana nekushomeka kwe testosterone.
Kunyora muAmerican Journal of Translational Research, vanyori vekudzidza vanotaura kuti vakadzidza mapoka maviri emakonzo.Rimwe boka rakaitwa orchidectomized (ORX; kuvhiyiwa castration), nepo rimwe boka rakavhiyiwa sham.Zvino, kwemavhiki makumi mana nemasere anotevera, mbeva dziri muboka reORX dzakagashira kudya kwakajairwa kana kudya kwakajairwa pamwe ne4 mg PQQ pakg yekudya.Iro sham-surgery mbeva boka rakagamuchira chete kudya kwakajairika.
Pakupera kwenguva yekuwedzera, vaongorori vakawana kuti boka re placebo reORX mbeva raive nekudzikisira kukuru kune bhonzo mineral density, trabecular bone volume, osteoblast nhamba, uye collagen deposition kana ichienzaniswa nesham mice.Nekudaro, boka rePQQ harina kuona kudzikiswa kwakadaro.Osteoclast pamusoro yakawedzerawo zvakanyanya muORX placebo boka kana ichienzaniswa nembeva dzinonyadzisa, asi yakadzikira zvakanyanya muboka rePQQ.
"Ichi chidzidzo chakaratidza kuti [PQQ] inobata basa rekudzivirira mu testosterone kushomeka-induced osteoporosis nekudzivisa oxidative kusagadzikana uye DNA kukuvara, cell apoptosis, nekusimudzira kupararira kweMSC uye kusiyanisa kuita osteoblasts uye nekudzivisa NF-κB kusaina mupfupa kuderedza. osteoclastic bone resorption,” vatsvakurudzi vakagumisa kudaro."Zvatinowana kubva muchidzidzo ichi zvakapa humbowo hwekuyedza kwekushandiswa kwekiriniki kwe [PQQ] kurapa osteoporosis muvarume vakura."
Wu X et al., "Pyrroloquinoline quinone inodzivirira kushomeka kwe testosterone-induced osteoporosis nekukurudzira osteoblastic bone kuumbwa uye inhibiting osteoclastic bone resorption," American Journal of Translational Research, vol.9, kwete.3 (Kurume, 2017): 1230–1242
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Nguva yekutumira: Oct-14-2019