Immunity ndiyo yega chipingamupinyi chakasimba kune hutano hwemuviri.Masoja ekudzivirira zvirwere anoshanda se“mauto” ari mumuviri, achirwisa “muvengi” anoisa utano hwedu pangozi mazuva ose, asi kazhinji kazhinji hatinzwi.Iyi "hondo" inotyisa imhaka yekuti "chikwata" ichi chine mukana wakakwana.Kamwe hutachiona hunoputsika, muviri wedu "uchaputsika" uye nhevedzano yezvirwere ichaonekwa, iyo isingangomanikidzi munhu, asiwo inoremedza mhuri.Kudzokororwa kwedenda idzva rekorona kwakawedzera kusimbisa kukosha kwekudzivirirwa kwevanhu.Tsvakurudzo dzinoverengeka dzakasimbisa kuti ginsenoside CK yakaita hukuru hukuru mukugadzirisa kwekudzivirira kwevanhu uye yakabudirira kuita nzira yayo kubva mumusika wezvokudya zvehutano.
MuChina, ginseng yakagara ichionekwa samambo wemishonga uye inozivikanwa se "yakanakisa kudya uye kusimbisa mumiriri muEast".Kumadokero, ginseng inonzi PANAX CA MEYERGINSENG, "PANAX" inobva muchiGiriki, zvinoreva "kurapa zvirwere zvose", uye "GINSENG" ndiyo mataurirwo echiChinese eginseng.Ginseng inogara isingaperi herbaceous chirimwa chiri cheiyo genus Araliaceae ginseng.Miti yerudzi rweAraliaceae yakabva kuCenozoic uye Tertiary Period, makore angangoita mamiriyoni makumi matanhatu apfuura.Apo Quaternary Ice Age yakasvika, nzvimbo yavo yekugara yakaderedzwa zvikuru.Ginseng uye ginseng Zvimwe zvinomera mujenasi zvakaponawo sezvisaririra zvekare.Izvi zvakare zvakakwana kuratidza kuti ginseng inogona kumira muyedzo kwezvakatipoteredza uye nguva, uye ichiri kubatsira kuhutano hwevanhu.
Basa rekare "Dream of Red Mansions" rinotaura nezve "Ginseng Yangrong Pill", inova mishonga inovaka muviri iyo Lin Daiyu inowanzotora.Lin Daiyu achangopinda muJia Mansion, uye munhu wese airatidza kuve neshomeka, saka vakamubvunza kuti chii chakashata?Mushonga werudzii?Daiyu akanyemwerera ndokuti: "Iye zvino ndichiri kudya mapiritsi eginseng Yangrong."Kusakwana isimba redziviriro redziviriro mune zvemazuva ano, izvo zvinoratidza zvakanakira ginseng mukuvandudza kusadzivirirwa.Pamusoro pezvo, "Compendium yeMateria Medica" uye "Dongyibaojian" zvakare inorekodha zvinyorwa zvine ginseng.
Kare, ginseng yaingofarirwa nemadzimambo nevakuru.Zvino yakakurumidza kubuda muAsia, ichigadzira "ginseng fever" kutenderera pasirese.Vatsvakurudzi vakawanda uye nyanzvi dzakatanga kudzidza ginseng nezvimwe zvinobva, ginseng extract uye ginsenosides (Ginsenoside) nezvimwe zvakadaro.
Saponins imhando yeglycosides uye inoumbwa nesapogenin uye shuga, uronic acid kana mamwe organic acids.Ginsenosides ndiwo musimboti weginseng, uye ndiwo makuru eparmacologically anoshanda zvikamu zveginseng, panax notoginseng uye American ginseng.Parizvino, vanenge makumi mashanu ginsenoside monomers vakaparadzaniswa.Iyo ginsenosides inotorwa zvakananga nenzira iyi inonzi prototype ginsenosides, kusanganisira Ra, Rb1, Rb2, Rb3, Re, Rg1, nezvimwewo muviri wemunhu.Nekudaro, huwandu hweiyo enzyme mumuviri idiki kwazvo, saka mwero wekushandiswa kwemuviri weiyo prototype ginsenoside wakadzikira.
Ginsenoside CK (Compound K) is glycol-type saponin, iyo ndeye isingawanzo ginsenosides.Inenge isipo mu ginseng yepanyama.Icho ndicho chikuru chekusvibisa chigadzirwa cheimwe yakakwirira-inowanikwa ginsenosides Rb1 uye Rg3 mudumbu remunhu.Iyo ine yakakwira biological chiitiko uye yakanyanya kutorwa nemuviri wemunhu.Pakare muna 1972, Yasioka et al.akawana ginsenoside CK kekutanga.Iyo "natural prodrug" dzidziso yakasimbisawo biological chiitiko cheginsenoside CK.Zvidzidzo zvakawanda zvakaratidza kuti anti-bundu uye mabasa ekusimudzira immune system ndiwo akasimba pakati peese ginsenosides.
Kubva ginsenoside Rg3 yakapinda mumusika, mhinduro yanga isingafadze.Vanhu vazhinji havazive kuti ginsenoside Rg3, iyo yagara ichivimbisa, ichokwadi chinhu chinonyungudika nemvura uye nemafuta chisingagoni kubatwa zvakananga nemuviri wemunhu, uye chiyero chekushandiswa kwayo chakaderera.Pasinei nokuti muviri unodya zvakadini, mhedzisiro yacho ishoma.
Kuti tikunde dambudziko iri, timu yeAmicogen's R&D yakaona kuburikidza nenhamba huru yezviyedzo kuti mamwe ma microorganisms ari mumuviri wemunhu anogona kushandura PPD fomu ginsenosides kuita CK fomu uye kuatora uye kuishandisa ne activate β-glucosaminease.Mushure memakore matanhatu ekutsvaga kwekunaya kwemvura, timu yakazobudirira kugadzira ginsenoside CK kuburikidza nekuvirisa, yakanyorera tekinoroji yakabatana patent, uye akadhindwa mapepa ane hukama.Kuenzaniswa neasidhi-base hydrolysis nzira uye enzyme yekushandura nzira, ine mabhenefiti asingaenzaniswi maererano nemutengo wekugadzira uye kugadzirwa kwemaindasitiri.Pakati pavo, zviri mukati meCK zvinogona kusvika kusvika ku15%, uye iyo yakajairwa yakatarwa ndeye 3%.Kugadzirwa kwakagadzirirwa kunogona kuitwa maererano nezvinodiwa, uye iyo yepamusoro inogona kugadzirwa 15%.Inogona kurondedzerwa sekubudirira kukuru mukutsvaga kweginsenosides.
Nekuda kwekuuya kweginsenoside CK, kune akawanda akawanda ekutsvagisa mazano uye mazano ekuchengetedza hutano hwemuviri, uye mamwe emakambani eR&D vashandi vanozofarira zvakanyanya mukushandiswa kwayo.Ginsenoside CK haingoite basa rakakosha mukudzivirira kwemuviri, asi zvakare ine huwandu hukuru hwe data yekuyedza kutsigira iyo anti-cancer, anti-diabetic, neuroprotective, ndangariro kuvandudza uye ganda mhedzisiro.Mune ramangwana, zvigadzirwa zvakawanda zvinotungamirwa neginsenoside CK zvichapinda zviuru zvemhuri kuchengetedza hutano hwemhuri dzavo.
Nguva yekutumira: Sep-09-2021