Sannadkii 1913, saynisyahan Iswiidhish ah Professor Kylin ayaa ka helay jaamacadda Uppsala qayb ka mid ah silbashada dhegta ee kelp, fucoidan.Sidoo kale loo yaqaan "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", iwm, magaca Ingiriisiga waa "Fucoidan".Waa walax polysaccharide ah oo biyaha ku milma oo ka kooban fukose ka kooban kooxo sulfate ah.Waxay inta badan ku jirtaa slime dusha sare ee algae brown (sida cawska badda, kudka wakame, iyo kelp).Waxa ku jira qiyaastii 0.1%, iyo waxa ku jira kelp qalalan waa ilaa 1%.Waa walax firfircoon oo aad u qiimo badan oo badda badda ah.
Marka hore, waxtarka fucoidan
Japan hadda waa dalka ugu cimriga dheer aduunka.Isla mar ahaantaana, Japan waxay leedahay mid ka mid ah heerarka ugu hooseeya ee cudurrada daba-dheeraada.Sida laga soo xigtay khubarada nafaqada, mid ka mid ah sababaha ugu muhiimsan ee caafimaadka dadka Japan ayaa laga yaabaa inay la xiriirto isticmaalka joogtada ah ee cuntooyinka badda badda.Fucoidan oo ku jira algae brown sida kelp waa walax firfircoon oo leh hawlo nafsiyeed oo kala duwan.Inkasta oo uu helay Professor Kylin 1913, ma ahayn ilaa 1996 in Fucoidan lagu daabacay Shirweynihii 55th ee Kansarka Japan.Warbixinta in "ay keeni karto apoptosis unugyada kansarka" waxay kicisay walaac baahsan oo ka jira bulshada tacliinta waxayna sababtay kor u kaca cilmi-baarista.
Waqtigan xaadirka ah, bulshada caafimaadku waxay wadaan cilmi-baaris ku saabsan shaqooyinka kala duwan ee bayooloji ee fucoidan, waxayna daabaceen kumanaan waraaqo ah joornaalada caafimaadka ee caalamiga ah, iyagoo xaqiijinaya in fucoidan uu leeyahay hawlo bayooloji oo kala duwan, sida ka hortagga burooyinka, hagaajinta habka dheef-shiid kiimikaadka, iyo antioxidant , Kor u qaadida difaac. , antithrombotic, cadaadiska dhiigga oo hooseeya, saamaynta fayraska.
(I) Fucoidan waxay wanaajisaa waxtarka caloosha iyo mindhicirka
Helicobacter pylori waa helical, microaerobic, bacilli gram-negative oo aad u baahan xaaladaha koritaanka.Waa noocyada microbial-ka kaliya ee hadda loo yaqaan inay ku noolaadaan caloosha bini'aadamka.Caabuqa Helicobacter pylori wuxuu keenaa gastritis iyo habka dheef-shiidka.Boogaha, lymphoproliferative lymphomas gastric gastric, iwm., waxay leeyihiin saadaal liidata ee kansarka caloosha.
Hababka cudur-sidaha ee H. pylori waxaa ka mid ah: (1) adhesion: H. pylori waxay u gudbi kartaa lakab xab ah oo u dheggan unugyada epithelial gastric;(2) ka takhalus aashitada gastric faa'iidada badbaadada: H. pylori waxay sii deysaa urease, iyo Urea caloosha waxay ka falcelisaa si ay u dhaliso gaaska ammonia, taas oo ka takhalusta aashitada gastric;(3) waxay baabi'isaa xabka caloosha: Helicobacter pylori waxay sii deysaa VacA sunta waxayna nabaadisaa unugyada dusha sare ee xabka caloosha;(4) waxay soo saartaa sunta chloramine: gaaska ammonia waxay si toos ah u baabi'isaa xuubka caloosha, iyo ogsijiinta falcelinta falcelinta waxay soo saartaa chloramine sun badan;(5) Waxay keentaa jawaab celin barar ah: Si looga hortago Helicobacter pylori, tiro badan oo unugyo cadcad ah ayaa ku soo urura xabka caloosha si ay u soo saaraan jawaab celin barar ah.
Saamaynta fucoidan ka dhanka ah Helicobacter pylori waxaa ka mid ah:
1. Joojinta faafinta Helicobacter pylori;
Sannadkii 2014, kooxda cilmi-baadhista Yun-Bae Kim ee Jaamacadda Qaranka ee Chungbuk ee Kuuriyada Koonfureed ayaa daabacday daraasad muujinaysa in fucoidan ay leedahay saameyn bakteeriyada bakteeriyada aad u wanaagsan, iyo fucoidan oo ku jira 100µg / mL waxay si buuxda u joojin kartaa kororka H. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Ka-hortagga ku-xidhka iyo duulaanka Helicobacter pylori;
Fucoidan waxaa ku jira kooxo sulfate ah waxayna ku xidhi kartaa Helicobacter pylori si ay uga ilaaliso inay ku dhegto unugyada epithelial gastric.Isla mar ahaantaana, Fucoidan waxay joojin kartaa wax soo saarka urease waxayna ilaalin kartaa jawiga acidic ee caloosha.
3. Saamaynta Antioxidant, waxay yaraysaa soosaarka sunta;
Fucoidan waa antioxidant wanaagsan, kaas oo si dhakhso ah u baabi'in kara xag-jirrada xorta ah ee ogsijiinta oo yarayn karta soo saarista sunta chloramine ee waxyeellada leh.
4. Saamaynta anti-bararka.
Fucoidan waxay joojin kartaa dhaqdhaqaaqa lectin xulashada, dhamaystirka iyo heparanase, waxayna yareyn kartaa jawaabta bararka.(Helicobacter, 2015, 20, 89-97.)
Intaa waxaa dheer, cilmi-baarayaashu waxay ogaadeen in fucoidan ay saameyn weyn ku leedahay hagaajinta caafimaadka mindhicirka waxayna leedahay saameyn laba-dhinac ah oo ku saabsan xiidmaha: hagaajinta calool-istaagga iyo enteritis.
2017, koox cilmi baaris ah oo ka socota Professor Ryuji Takeda oo ka tirsan Jaamacadda Kansai ee Sayniska Welfare ee Japan ayaa sameeyay daraasad.Waxay doorteen 30 bukaan oo calool istaag ah waxayna u kala qaybiyeen laba kooxood.Kooxda tijaabada ah ayaa la siiyay 1 g oo fucoidan ah kooxda xakamaynta waxaa la siiyay placebo.Labo bilood ka dib baaritaanka, waxaa la ogaaday in tirada maalmaha saxarada todobaadkii ee kooxda imtixaanka fucoidan ay korodhay celcelis ahaan 2.7 maalmood ilaa 4.6 maalmood, mugga saxarada iyo jilicsanaanta ayaa si aad ah u kordhay.(Cuntada shaqaynaysa ee Caafimaadka iyo Cudurada 2017, 7: 735-742.)
2015, koox ka mid ah Professor Nuri Gueven oo ka tirsan Jaamacadda Tasmania, Australia, ayaa ogaaday in fucoidan uu si wax ku ool ah u wanaajin karo enteritis ee jiirarka, dhinaca kale, waxay ka caawin kartaa jiirarka soo celinta miisaanka iyo kordhinta adkaanta saxarada;dhanka kale, waxay dhimi kartaa miisaanka mindhicirka iyo beeryarada.Wuxuu yareeyaa caabuqa jirka.(PLoS ONE 2015, 10: e0128453.)
B) Saamaynta antitumor ee fucoidan
Cilmi-baarista saameynta antitumor ee fucoidan ayaa hadda ah tan ugu walaacsan wareegyada tacliinta, natiijooyin badan oo cilmi-baaris ah ayaa la helay.
1. Habaynta wareegga unugyada burada
2015, Professor Lee Sang Hun iyo kuwa kale oo ka tirsan Jaamacadda Soonchunhyang ee Koonfurta Kuuriya iyo cilmi-baarayaal kale ayaa ogaaday in fucoidan ay joojiso muujinta cyclin Cyclin iyo cyclin kinase CDK ee unugyada burooyinka iyada oo la xakameynayo wareegga koritaanka unugyada kansarka mindhicirka ee bini'aadamka, taas oo saameynaysa mitosis caadiga ah. unugyada burooyinka.Stagnate unugyada burooyinka marxaladda hore ee mitotic waxayna joojiyaan kororka unugyada burooyinka.(Wararka Daawaynta Molecular, 2015, 12, 3446.)
2.Induction of apoptosis unugyada burada
2012, daraasad ay daabacday kooxda cilmi-baarista Quan Li ee Jaamacadda Qingdao waxay ogaatay in fucoidan uu kicin karo calaamadda apoptosis ee unugyada burooyinka-Bax apoptosis borotiinka, wuxuu keenaa dhaawaca DNA unugyada kansarka naasaha, isku-darka koromosoomyada, iyo inuu keeno apoptosis kedis ah unugyada burooyinka., Waxay joojisay koritaanka unugyada burooyinka ee jiirarka.(Plos One, 2012, 7, e43483.)
3.Waxay joojisaa metastasis-ka unugyada burada
2015, Chang-Jer Wu iyo cilmi-baarayaal kale oo ka socda Jaamacadda Qaranka ee Badweynta Taiwan ayaa daabacay cilmi-baaris muujinaya in fucoidan uu kordhin karo muujinta unugyada inhibitory factor (TIMP) iyo hoos-u-habaynta matrix metalloproteinase (MMP), taas oo ka hortagaysa metastasis unugga unugyada.(Mar. Daawooyinka 2015, 13, 1882.)
4.Waxay joojisaa buro angiogenesis
2015, kooxda cilmi-baarista Tz-Chong Chou ee Xarunta Caafimaadka ee Taiwan waxay ogaatay in fucoidan ay yareyn karto wax soo saarka xuubka xuubka xuubka xuubka (VEGF), wuxuu xakameynayaa neovascularization ee burooyinka, gooyaa sahayda nafaqada ee burooyinka, gaajada burooyinka Xadka ugu weyn Jooji faafidda iyo metastasis-ka unugyada burooyinka.(Mar. Dawooyinka 2015, 13, 4436.)
5.Dhaqdhaqaaqa habka difaaca jidhka
Sanadkii 2006, Professor Takahisa Nakano oo ka tirsan Jaamacadda Kitasatouniversity ee Japan ayaa daahfuray in fucoidan ay kor u qaadi karto difaaca jirka oo ay isticmaasho habdhiska difaaca bukaanka si ay si gaar ah u disho unugyada kansarka.Ka dib marka fucoidan uu galo mareenka mindhicirka, waxaa aqoonsan kara unugyada difaaca jirka, waxay abuuraan calaamado dhaqaajiya habka difaaca jirka, waxayna dhaqaajiyaan unugyada NK, unugyada B, iyo unugyada T, taas oo soo saarta unugyada difaaca jirka ee ku xiran unugyada kansarka iyo unugyada T ee dilaaga kansarka. unugyo.Dil gaar ah oo loo geysto unugyada kansarka, xannibaya koritaanka unugyada kansarka.(Planta Medica, 2006, 72, 1415.)
Soo saarista Fucoidan
Waxyaabaha ku jira kooxaha sulfate-ka ee qaab-dhismeedka molecular ee fucoidan waa tilmaame muhiim ah oo go'aaminaya dhaqdhaqaaqiisa jireed, iyo sidoo kale waa qayb muhiim ah oo ka mid ah xiriirka qaab-dhismeedka-firfircoon ee fucoidan.Sidaa darteed, waxa ku jira kooxda sulfate-ku waa halbeeg muhiim ah oo lagu qiimeeyo tayada fucoidan iyo xidhiidhka qaab-dhismeedka.
Dhawaan, shatiga wax-soo-saarka cuntada ee fucoidan polysaccharide waxaa ugu dambeyntii shahaado siiyay Maamulka Cuntada iyo Dawooyinka waxaana la siiyay Kooxda Qingdao Mingyue Seaweed, taas oo macnaheedu yahay in Minyue Seaweed Group ay si qoto dheer u beeranayeen badda in ka badan 50 sano.Hel shahaado rasmi ah.Waxaa la soo wariyay in kooxda Mingyue Seaweed ay dhistay khad wax soo saar fucoidan ah oo soo saara sanadle ah 10 tan.Mustaqbalka, waxay siin doontaa ciyaar buuxda si ay u saameynayso "daawoyinka iyo cunnada cunnada" saamaynta iyo dhalaalidda goobta cuntada ee shaqeynaya ee warshadaha caafimaadka ee waaweyn.
Mingyue Seaweed Group, sida shirkad loo ansixiyey soo saarista cuntada fucoidan, waxay leedahay waayo-aragnimo wax soo saar sanado badan.Fucoidan-ka ay soo saartay waa wax soo saar farsamo oo casriyeyn ah oo ka mid ah asalka kelp xoogga/budada.Isticmaalka algae brown ee tayada sare leh ee cuntada sida alaabta ceeriin, nadiifinta dheeraadka ah iyo kala-soocida ku salaysan tignoolajiyada soo saarista dabiiciga ah, kaliya ma wanaajiso dhadhanka iyo dhadhanka alaabta, laakiin sidoo kale waxay kordhisaa maadada polysaccharide fucoidan (nadiif), taas oo loo isticmaali karo qaybo badan sida cuntooyinka shaqada iyo cuntooyinka caafimaadka..Waxay leedahay faa'iidooyinka nadiifinta alaabta sare iyo maadada sare ee kooxaha shaqada;saarista biraha culus, badbaadada sare;macaanaynta iyo kalluunka, dhadhanka iyo hagaajinta dhadhanka.
Codsiga Fucoidan
Waqtigan xaadirka ah, waxaa jira badeecooyin badan oo fucoidan ah oo la sameeyay laguna dabaqay Japan, South Korea, Mareykanka iyo wadamo kale, sida fucoidan xoog leh, fucoidan soosaar kaabsoosha ceeriin, iyo saliidayn super fucoidan badeed.Cuntooyinka shaqada leh sida Kooxda Seaweed ee Qingyou Le, Treasure Rockweed, Cabbitaannada Dhirta Algae Brown
Sanadihii la soo dhaafay, "Warbixinta Xaaladda Nafaqada Dadka Degan Shiinaha iyo Cudurrada Joogtada ah" waxay muujineysaa in qaab-dhismeedka cuntada ee dadka deggan Shiinaha uu isbeddelay, iyo faafitaanka cudurrada daba-dheeraada ayaa sii kordhaya.Mashaariic caafimaad oo waaweyn oo ku salaysan "daweynta cudurrada" ayaa soo jiitay dareen badan.Isticmaalka fucoidan si loo horumariyo oo loo soo saaro cuntooyin badan oo shaqeynaya ayaa si buuxda u sahamin doona qiimaha faa'iidada leh ee fucoidan si loo siiyo nolol iyo caafimaad, taas oo muhiimad weyn u leh horumarinta "daaw caafimaad leh iyo cunto isku mid ah" warshado caafimaad oo waaweyn.
Isku xirka alaabta:https://www.trbextract.com/1926.html
Waqtiga boostada: Mar-24-2020