Pyrroloquinoline quinone (PQQ), oo ah antioxidant laga helo cuntooyinka sida kiwifruit, ayaa lagu ogaaday in ay bixiso faa'iidooyinka caafimaadka lafaha cilmi-baaristii hore, oo ay ku jiraan daraasado soo jeedinaya in ay joojiso dib-u-celinta lafaha lafaha (osteoclastogenesis) waxayna kor u qaadaa sameynta lafaha osteoblastic (osteoblastogenesis).Laakiin natiijooyinka cilmi-baarista xayawaanka cusub ayaa ogaaday, markii ugu horeysay, in maaddadu sidoo kale laga yaabo inay ka hortagto lafo-beelka oo ay keento yaraanta testosterone.
Inkasta oo lafo-jileecu ay ku xiran tahay menopause waa arrin caafimaad oo si fiican loo aqoonsan yahay haweenka, yaraanta testosterone-ku-dhiman lafo-beelka ragga ayaa dhab ahaantii la ogaaday in ay ku xiran tahay xanuunka weyn iyo heerka dhimashada ka dib jabka lafaha, inkastoo ay u egtahay in ay ku dhacdo nolosha dambe marka loo eego osteoporosis postmenopausal. dumarka.Si kastaba ha ahaatee, ilaa hadda, cilmi-baarayaashu ma aysan baarin in PQQ ay hagaajin karto lafo-jileeca oo ku xiran yaraanta testosterone.
Qoritaanka joornaalka Mareykanka ee Cilmi-baarista Turjumaada, qorayaasha daraasadda ayaa sheegay in ay daraasad ku sameeyeen laba kooxood oo jiirar ah.Mid ka mid ah koox ayaa la sameeyay orchidectomized (ORX; qalliinka qalliinka), halka kooxda kale lagu sameeyay qalliin shaam ah.Kadib, 48da usbuuc ee soo socda, jiirarka kooxda ORX waxay heleen cunto caadi ah ama cunto caadi ah oo lagu daray 4 mg PQQ kiilo kasta oo cunto ah.Kooxda jiirarka shaam-ku-qaliinka waxay heleen kaliya cunto caadi ah.
Dhammaadka muddada dheeriga ah, cilmi-baarayaashu waxay ogaadeen in kooxda placebo ee jiirarka ORX ay si weyn hoos ugu dhacday cufnaanta macdanta lafaha, mugga lafaha trabecular, lambarka osteoblast, iyo kaydinta kolajka marka la barbardhigo jiirarka shaambada ah.Si kastaba ha ahaatee, kooxda PQQ inta badan ma aysan la kulmin dhimistaas.Dusha Osteoclast sidoo kale si weyn ayaa loogu kordhay kooxda ORX placebo marka la barbar dhigo jiirarka xishoodka, laakiin si weyn ayaa hoos ugu dhacay kooxda PQQ.
"Daraasaddani waxay muujisay in [PQQ] ay door ka qaadato ka-hortagga lafa-beelka testosterone-ka-soo-baxa osteoporosis iyada oo la xakameynayo cadaadiska oksaydhka iyo dhaawaca DNA-ga, apoptosis unug, iyo kor u qaadida faafinta MSC iyo kala-duwanaanta osteoblasts iyo iyada oo la xakameynayo calaamadaha NF-κB ee lafaha si loo yareeyo dib-u-celinta lafaha osteoclastic," cilmi-baarayaashu waxay soo gabagabeeyeen."Natiijooyinkayada daraasaddan waxay bixiyeen caddayn tijaabo ah oo ku saabsan codsiga bukaan-socodka ee [PQQ] si loogu daweeyo lafo-beelka ragga da'da ah."
Wu X et al., "Pyrroloquinoline quinone waxay ka hortagtaa osteoporosis yaraanta testosterone iyada oo kicinaysa samaynta lafaha osteoblastic iyo joojinta dib u soo celinta lafaha osteoclastic," Joornaalka Maraykanka ee Cilmi-baarista Turjumaada, vol.9, maya.3 (Maarso, 2017): 1230–1242
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Waqtiga boostada: Oct-14-2019