Spermine Tetrahydrochloride

Short Description:

Spermine Tetrahydrochloride is a polyamine, derived from spermidine, which is required for eukaryotic cell growth. It acts as a regulator of gene expression, inhibits DNA damage and protects cells from damage by acting as a free radical scavenger. In proteomic studies, spermine mediates rapid crystallization of DNA-binding proteins. It has great effect to anti age and prevent Alzheimer’s disease.

Spermine Tetrahydrochloride CAS NO. 306-67-2 is a polyamine that participates in cellular metabolism in eukaryotic cells. Spermine Tetrahydrochloride CAS NO. 306-67-2 is a major natural intracellular compound that can protect DNA from free radical attacks.Spermine Tetrahydrochloride CAS NO. 306-67-2 is also an agonist antagonist and can inhibit neuronal synthase activity.

Spermine tetrahydrochloride is a compound that plays a key role in a variety of biological processes. It is a derivative of spermine, but with four chloride ions added. This slight modification can significantly affect its features and functionality. Spermine tetrahydrochloride is a polyamine, a group of organic compounds with multiple amino groups. Polyamines are essential for cell growth and survival and are involved in a variety of cellular processes, including DNA replication, transcription, and translation. One of the primary functions of spermine tetrahydrochloride is its ability to stabilize DNA. It does this by binding to the negatively charged phosphate groups of DNA, neutralizing its charge and promoting the formation of stable and compact DNA structures. This stability is critical for proper DNA packaging and organization, ultimately affecting gene expression and cellular function. In addition, spermine tetrahydrochloride is involved in the regulation of enzyme activity. It can interact with enzymes and modulate their function by changing their structure or affecting their catalytic activity. This process is critical for maintaining cellular homeostasis and ensuring the proper functioning of enzymatic pathways. Spermine tetrahydrochloride also plays a role in cell signaling and membrane stability. It can interact with phospholipids, the main component of cell membranes. This interaction helps maintain the integrity of the cell membrane and regulates the transport of molecules in and out of the cell.


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  • Product Detail

    Product Tags

    Product Name:Spermine Tetrahydrochloride

    CAS No:306-67-2

    Assay:  98.0%Min

    Colour: off-White solid

    Packing:25kgs/drum

    Spermine Tetrahydrochloride: High-Purity Molecular Biology Grade Reagent for DNA Precipitation

    Product Overview
    Spermine Tetrahydrochloride (CAS: 306-67-2) is a polyamine compound widely used in molecular biology and biochemical research. As the tetrahydrochloride salt of spermine, it plays a critical role in DNA stabilization and crystallization, particularly in low-salt buffers . This reagent is classified as Molecular Biology Grade, ensuring high reliability for sensitive experimental applications .

    Key Features

    1. High Purity & Quality Control
      • Assay: 98.5%~101.5% (HPLC)  or ≥95% (alternative specifications available) .
      • Rigorous quality control with Certificates of Analysis (COA) provided .
    2. Versatile Applications
      • DNA Precipitation: Efficiently precipitates DNA from low-salt aqueous buffers, ideal for protein-DNA interaction studies .
      • Cell Metabolism: Essential for eukaryotic cell proliferation and differentiation, inhibits neuronal nitric oxide synthase (nNOS) .
      • Antioxidant Properties: Protects DNA from free radical damage .
      • Potential Antineoplastic Activity: Emerging research suggests roles in controlling cancer cell growth, though further studies are needed .
    3. Physical & Chemical Properties
      • Molecular Formula: C₁₀H₂₆N₄·4HCl .
      • Molecular Weight: 348.18 g/mol .
      • Solubility: ≥100 mg/mL in water .
      • Storage: Stable at room temperature (10–30°C) or 2–8°C depending on packaging .

    Packaging & Availability

    • Standard Sizes: 1 g, 5 g (custom quantities available upon request) .
    • Global Stock: Ready-to-ship with expedited delivery options .

    Safety & Compliance

    • GHS Compliance: Classified as a skin corrosive (Category 1B) and severe eye irritant (Category 1). Proper PPE (gloves, goggles) is mandatory during handling .
    • Regulatory Status: Listed in EINECS (206-189-8), TSCA, and China’s hazardous chemical directory .

    Why Choose Our Product?

    • Research-Grade Reliability: Optimized for reproducibility in DNA-related assays .
    • Technical Support: Detailed protocols and expert consultation available.
    • Keywords: Spermine Tetrahydrochloride, CAS 306-67-2, DNA precipitation reagent, polyamine, endogenous metabolite, molecular biology grade.

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