Motsoako oa tlhaho o fumanoang fragole le litholoana tse ling le meroho e ka thusa ho thibela lefu la Alzheimer le mafu a mang a amanang le botsofali a amanang le botsofali, lipatlisiso tse ncha li fana ka maikutlo.
Bafuputsi ba Salk Institute for Biological Studies e La Jolla, CA, le basebetsi-'moho le bona ba fumane hore ho phekola mehlala ea litoeba tsa botsofali ka fisetin ho lebisitse ho fokotseha ha kelello le ho ruruha ha boko.
Mongoli e moholo oa boithuto, Pamela Maher, oa Cellular Neurobiology Laboratory e Salk, le basebetsi-’moho haufinyane ba tlalehile seo ba se fumaneng ho The Journals of Gerontology Series A.
Fisetin ke flavanol e teng ka mefuta e fapaneng ea litholoana le meroho, ho akarelletsa le fragole, persimmons, liapole, morara, eiee le likomkomere.
Hase feela hore fisetin e sebetsa e le moemeli oa mebala bakeng sa litholoana le meroho, empa liphuputso li bontšitse hore motsoako o na le thepa ea antioxidant, e bolelang hore e ka thusa ho fokotsa tšenyo ea lisele e bakoang ke li-radicals tsa mahala.Fisetin e boetse e bontšitsoe ho fokotsa ho ruruha.
Lilemong tse 10 tse fetileng, Maher le basebetsi-'moho ba entse liphuputso tse 'maloa tse bontšang hore antioxidant le anti-inflammatory properties tsa fisetin li ka thusa ho sireletsa lisele tsa boko khahlanong le liphello tsa botsofali.
Phuputso e 'ngoe e joalo, e hatisitsoeng ka 2014, e fumane hore fisetin e fokolitse tahlehelo ea mohopolo mefuteng ea litoeba tsa lefu la Alzheimer's.Leha ho le joalo, thuto eo e ile ea lebisa tlhokomelo liphellong tsa fisetin ho litoeba tse nang le lefu la Alzheimer's, leo bafuputsi ba hlokomelang hore ke karolo ea 3 lekholong feela ea Alzheimer's.
Bakeng sa thuto e ncha, Maher le sehlopha ba ile ba batla ho fumana hore na fisetin e ka ba le melemo bakeng sa lefu la Alzheimer's sporadic, e leng mofuta o atileng haholo o hlahang ka lilemo.
Ho fihlela seo ba se fumaneng, bafuputsi ba ile ba etsa liteko tsa fisetin ho litoeba tse neng li entsoe ka liphatsa tsa lefutso hore li tsofale pele ho nako, e leng se ileng sa fella ka mofuta oa toeba oa lefu la Alzheimer's sporadic.
Ha litoeba tse tsofalang pele ho nako li ne li le likhoeli tse 3, li ile tsa aroloa ka lihlopha tse peli.Sehlopha se seng se ile sa feptjoa tekanyo ea fisetin ka lijo tsa sona letsatsi le leng le le leng ka likhoeli tse 7, ho fihlela se fihla lilemong tsa likhoeli tse 10.Sehlopha se seng ha sea ka sa amohela kompone.
Sehlopha se hlalosa hore nakong ea likhoeli tsa 10, maemo a 'mele le a kelello a litoeba a ne a lekana le a litoeba tse lilemo li 2.
Litoeba tsohle li ne li le tlas'a liteko tsa kelello le tsa boitšoaro nakong eohle ea thuto, 'me bafuputsi ba boetse ba lekola litoeba bakeng sa maemo a matšoao a amanang le khatello ea maikutlo le ho ruruha.
Bafuputsi ba fumane hore litoeba tsa likhoeli tsa 10 tse sa kang tsa fumana fisetin li bontšitse keketseho ea matšoao a amanang le khatello ea kelello le ho ruruha, 'me li ile tsa boela tsa etsa hampe haholo litekong tsa kelello ho feta litoeba tse neng li tšoaroa ka fisetin.
Bokong ba litoeba tse sa phekoloeng, bafuputsi ba fumane hore mefuta e 'meli ea li-neuron tseo hangata li thibelang ho ruruha - astrocytes le microglia - li ne li hlile li khothalletsa ho ruruha.Leha ho le joalo, ho ne ho se joalo bakeng sa litoeba tsa likhoeli tse 10 tse phekoloang ka fisetin.
Ho feta moo, bafuputsi ba fumane hore boitšoaro le ts'ebetso ea kelello ea litoeba tse tšoaroang li ne li tšoana le tsa litoeba tse sa phekoloang tsa likhoeli tsa 3.
Bafuputsi ba lumela hore liphuputso tsa bona li bontša hore fisetin e ka lebisa ho leano le lecha la thibelo bakeng sa Alzheimer's, hammoho le mafu a mang a amanang le botsofali a amanang le botsofali.
"Ho ipapisitse le mosebetsi oa rona o ntseng o tsoela pele, re nahana hore fisetin e ka thusa joalo ka thibelo ea mafu a mangata a amanang le lilemo, eseng a Alzheimer's feela, 'me re ka thabela ho khothaletsa boithuto bo matla haholoanyane ka ona," ho bolela Maher.
Leha ho le joalo, bafuputsi ba hlokomela hore liteko tsa kliniki tsa batho lia hlokahala ho netefatsa liphetho tsa bona.Ba na le tšepo ea ho kopana le bafuputsi ba bang ho finyella tlhoko ena.
“Ehlile, litoeba ha se batho.Empa ho na le ho tšoana ho lekaneng hoo re nahanang hore fisetin e hloka ho hlahlobisisa, eseng feela bakeng sa ho phekola AD [lefu la Alzheimer] e ka ’nang ea etsahala, empa hape le bakeng sa ho fokotsa tse ling tsa liphello tsa kelello tse amanang le botsofali, ka kakaretso.”
Nako ea poso: Apr-18-2020