Covid-19, kapa e tsejoang hape e le vaerase ea 2019-nCoV kapa SARS-CoV-2, ke ea lelapa la Coronavirus.Kaha SARS-CoV-2 ke ea mofuta oa β Coronavirus e amana haufi-ufi le MERS-CoV le SARS-CoV - tseo hape ho tlalehiloeng hore li baka matšoao a matla a nyumonia mafung a seoa a fetileng.Sebopeho sa liphatsa tsa lefutso tsa 2019-nCoV se tšoailoe le ho phatlalatsoa.[i] [ii] Liprotheine tse ka sehloohong tsa kokoana-hloko ena le tse neng li tsejoa pele ho SARS-CoV kapa MERS-CoV li bontša ho tšoana ho phahameng pakeng tsa tsona.
Ntho e ncha ea mofuta ona oa kokoana-hloko e bolela hore ho na le lipelaelo tse ngata tse mabapi le boits'oaro ba eona, ka hona ho sa le pele haholo ho tseba hore na limela kapa metsoako ea litlama e ka kenya letsoho sechabeng e le li-prophylactic agents kapa e le lintho tse loketseng lithethefatsing tsa anti-coronavirus khahlano le Covid. -19.Leha ho le joalo, ka lebaka la ho tšoana ho phahameng ha Covid-19 le livaerase tsa SARS-CoV le MERS-CoV tse tlalehiloeng pele, lipatlisiso tse hatisitsoeng tse fetileng mabapi le metsoako ea litlama, tse netefalitsoeng hore li na le litlamorao tsa anti-coronavirus, e ka ba tataiso ea bohlokoa ea ho fumana anti-coronavirus. limela tsa litlama, tse ka bang mafolofolo khahlano le vaerase ea SARS-CoV-2.
Kamora ho phatloha ha SARS-CoV, e tlalehiloeng ka lekhetlo la pele mathoasong a 2003[iii], bo-ramahlale ba ntse ba leka ka matla ho sebelisa metsoako e mengata ea antiviral khahlano le SARS-CoV.Sena se entse hore sehlopha sa litsebi tsa China se hlahlobe litlama tse fetang 200 tsa litlama tsa China bakeng sa ts'ebetso ea antiviral khahlano le mofuta ona oa coronavirus.
Har'a tsena, likhakanyo tse 'ne li bonts'itse litlamorao tse matla ho isa ho tse matla khahlano le SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (Lengana le monate) le Lindera aggregate (setho se nkhang hamonate se lulang se le setala sa lelapa la laurel. ).Liphello tsa antiviral tsa tsena li ne li itšetlehile ka lethal dose 'me li fapana ho tloha ho tse fokolang ho ea holimo ho ea holimo, ho fapana bakeng sa motso o mong le o mong oa litlama.Haholo-holo Lycoris radiata e bontšitse ts'ebetso e matla ka ho fetesisa ea antiviral khahlano le mofuta oa vaerase.[iv]
Sephetho sena se ne se lumellana le sa lihlopha tse ling tse peli tsa lipatlisiso, tse ileng tsa fana ka maikutlo a hore karolo e sebetsang e ka har'a metso ea Licorice, Glycyrrhizin, e netefalitsoe hore e na le ts'ebetso e khahlanong le SARS-CoV ka ho thibela phetisetso ea eona.[v] [vi] Ho e 'ngoe. boithutong, Glycyrrhizin e boetse e bonts'itse ts'ebetso ea antiviral ha e lekoa bakeng sa litlamorao tsa eona tsa in vitro antiviral libakeng tse 10 tse ikhethileng tsa bongaka tsa SARS coronavirus.Baicalin - karolo ea semela sa Scuttelaria baikalensis (Skullcap) - le eona e kile ea lekoa phuputsong ena tlas'a maemo a tšoanang 'me e boetse e bontšitse khato e thibelang kokoana-hloko khahlanong le coronavirus ea SARS.[vii] Baicalin e boetse e bontšitsoe ho thibela ho ikatisa ha HIV. -1 kokoana-hloko ea in vitro lithutong tse fetileng.[viii] [ix] Leha ho le joalo ho lokela ho hlokomeloa hore liphuputso tsa in vitro li ka 'na tsa se ke tsa amana le katleho ea kliniki ea vivo.Lebaka ke hobane tekanyo ea molomo ea li-agent tsena ho batho e ka 'na ea se ke ea finyella serum ea mali e tšoanang le e lekiloeng ka in vitro.
Lycorine e boetse e bonts'itse ts'ebetso e matla ea antiviral khahlano le SARS-CoV.3 Litlaleho tse 'maloa tse fetileng li fana ka maikutlo a hore Lycorine e bonahala e na le ts'ebetso e pharalletseng ea antiviral mme ho tlalehiloe hore e bontšitse ketso e thibelang kokoana-hloko ea Herpes Simplex (mofuta oa I)[x] le Poliomyelitis. kokoana-hloko le eona.[xi]
Litlama tse ling tse tlalehiloeng li bontšitse tšebetso ea antiviral khahlano le SARS-CoV ke Lonicera japonica (Honeysuckle ea Japane) le semela se tsebahalang sa Eucalyptus, le Panax ginseng (motso) ka karolo ea eona e sebetsang ea Ginsenoside-Rb1."[xii]
Bopaki bo tsoang liphuputsong tse boletsoeng ka holimo le liphuputso tse ling tse ngata lefatšeng ka bophara li tlaleha hore metsoako e mengata ea meriana ea litlama e bontšitse liketso tse thibelang kokoana-hloko khahlanong le coronavirus [xiii] [xiv] 'me mokhoa oa bona o ka sehloohong oa ts'ebetso o bonahala e le ka ho thibela ho ikatisa ha kokoana-hloko.[xv] Chaena. e sebelisitse haholo litlama tsa setso tsa Machaena bakeng sa ho alafa SARS ka katleho maemong a mangata.[xvi] Leha ho le joalo ha ho na bopaki bo tiileng mabapi le katleho ea meriana ena bakeng sa bakuli ba tšoaelitsoeng Covid-19.
Na li-extracts tse joalo tsa litlama e ka ba batho ba ka ntlafatsang litlhare tse ncha tsa antiviral bakeng sa thibelo kapa kalafo ea SARS?
TLHOKOMELISO: Sengoliloeng sena se ngoletsoe merero ea tlhahisoleseling feela, 'me ha ea rereloa ho nka sebaka sa likeletso tsa bongaka, tlhahlobo kapa kalafo.Haeba u nahana hore u ka ba le matšoao a amanang le a Covid-19 kapa lefu lefe kapa lefe, letsetsa ngaka ea hau hanghang.
[I] Zhou, P., Yang, X., Wang, X. et al., 2020. Ho qhoma ha nyumonia ho amanang le coronavirus e ncha ea tšimoloho ea 'mankhane.Tlhaho 579, 270–273 (2020).https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC le Garry, RF, 2020. Tšimoloho e haufi ea SARS-CoV-2.Meriana ea Tlhaho, maq.1-3.
[iii] Kemiso ea nako ea Karabelo ea CDC SARS.E fumaneha ho https://www.cdc.gov/about/history/sars/timeline.htm.E kenelletse
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG le Li, RS, 2005. Ho tsebahatsa metsoako ea tlhaho e nang le mesebetsi e thibelang kokoana-hloko khahlanong le coronavirus e amanang le SARS.Patlisiso ea antiviral, 67(1), maq.18-23.
[v] Cinatl, J., Morgenstem, B. le Bauer, G., 2003. Glycyrrhizin, karolo e sebetsang ea metso ea licorice le ho pheta-pheta ha coronovirus e amanang le SARS.Lancet, 361(9374), pp.2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW le Cinatl, J., 2005. Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS− Coronavirus.Journal of chemistry ea meriana, 48 (4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW le Guan, Y., 2004. In vitro susceptibility ea li- isolates tse 10 tsa kliniki tsa SARS coronavirus ho metsoako e khethiloeng ea antiviral.Journal of Clinical Virology, 31 (1), leqepheng la 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. and Tokunaga, T., 1998. Baicalin, an inhibitor of Tlhahiso ea HIV-1 in vitro.Patlisiso ea antiviral, 37 (2), maq.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW le Wang, JM, 2000. Flavonoid baicalin e thibela tšoaetso ea HIV-1 boemong ba ho kena ha kokoana-hloko.Lipuisano tsa lipatlisiso tsa biochemical le biophysical, 276 (2), maq.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. le Kobayashi, S., 1989. Phello ea alkaloids e arohaneng le Amaryllidaceae ka kokoana-hloko ea herpes simplex.Patlisiso ka virology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. le Alderweireldt, F., 1982. Li-antiviral agents.III.Ho itšehla thajana ha alkaloids ho tloha ho Clivia miniata Regel (Amaryl-lidaceae).Journal of Natural Products, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. le Liang, FS, 2004 Limolek'hule tse nyane tse shebileng lefu le matla la ho hema la motho.Melato ea Sekolo sa Sechaba sa Saense, 101 (27), maq.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS and Hou, CC, 2007. Specific Semela sa terpenoids le lignoids li na le ts'ebetso e matla ea antiviral khahlano le lefu le matla la ho hema la coronavirus.Journal of chemistry ea meriana, 50 (17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW le Towers, GHN, 1995. Tlhahlobo ea antiviral ea limela tsa meriana tsa British Columbian.Journal of Ethnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA le Naji, MA, 2003. Novel antiviral agents: pono ea semela sa meriana.Journal of applied microbiology, 95 (3), pp.412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. le Liu, JP, 2020. Na meriana ea Sechaena e ka sebelisoa ho thibela lefu la corona virus 2019 (COVID -19)Tlhahlobo ea li-classics tsa histori, bopaki ba lipatlisiso le mananeo a hona joale a thibelo.Chinese Journal of Integrative Medicine, leqepheng la 1-8.
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Nako ea poso: Apr-18-2020