Product Name:Sunifiram
Other Name: DM235
Chemical name:1-(4-Benzoylpiperazin-1-yl)propan-1-one; 1-Benzoyl-4-(1-oxopropyl)piperazine
CAS NO.: 314728-85-3
Purity: 99.5%
Appearance: white crystalline powder
Package:1kg/bag
Sunifiram: A Comprehensive Guide to the Potent Nootropic for Cognitive Enhancement
Introduction
Sunifiram (DM-235) is a synthetic nootropic compound derived from the racetam family, renowned for its potential to enhance cognitive functions such as memory, focus, and learning capacity . Despite its experimental status and lack of approval for medical use, it has gained attention in the nootropics community for its high potency—reportedly 1,000 times stronger than piracetam . This guide explores its mechanisms, benefits, dosage, and safety considerations, tailored to meet the search preferences of欧美客户 and align with Google’s content standards.
Mechanism of Action
Sunifiram primarily interacts with AMPA and NMDA receptors in the brain, enhancing glutamate signaling—a key neurotransmitter for synaptic plasticity and memory formation . Unlike traditional racetams, it also modulates cholinergic pathways, increasing acetylcholine release to support learning and attention . Animal studies suggest it activates intracellular proteins like CaMKII and PKCα, further amplifying cognitive benefits . However, its exact mechanism remains under investigation, with some studies reporting no affinity for common receptors .
Key Benefits
- Memory Enhancement
- Improves both short-term and long-term memory by promoting long-term potentiation (LTP) .
- Reverses scopolamine-induced amnesia in animal models at doses 10–10,000× lower than piracetam .
- Focus and Mental Clarity
- Enhances attention span by optimizing glutamate receptor activity, aiding tasks requiring sustained concentration .
- Mood and Energy Boost
- Anecdotal reports highlight increased alertness and reduced anxiety, though clinical evidence is limited .
- Neuroprotective Potential
- May protect against cognitive decline in conditions like Alzheimer’s, as suggested by preclinical studies .
Recommended Dosage
- Starting Dose: 5 mg once or twice daily, taken sublingually or orally for faster absorption .
- Maximum Dose: Do not exceed 10 mg/day to avoid side effects like headaches or insomnia .
- Cycling: Use for 4–6 weeks followed by a 1–2 week break to maintain efficacy .
Note: Always consult a healthcare professional before use, especially if combining with other nootropics like Alpha-GPC or racetams .
Safety and Side Effects
- Common Side Effects: Headaches, restlessness, hot flashes, and sleep disturbances at higher doses .
- Lack of Human Trials: No clinical studies confirm long-term safety; rely on animal research and user reports .
- Legal Status: Not approved for medical use globally. Available as a research chemical in some countries (e.g., Japan, Italy) .
FAQs
- How quickly does Sunifiram work?
Effects onset within 30–60 minutes, with a short half-life of 1–2 hours requiring redosing for sustained benefits . - Is it safe for long-term use?
Limited data exist. Prioritize cycling and adhere to dosage guidelines . - Can it replace prescription cognitive enhancers like Modafinil?
While more potent than racetams, Sunifiram lacks human trials for direct comparison .
Conclusion
Sunifiram offers promising cognitive benefits but remains experimental. Its high potency demands cautious use, emphasizing low doses and professional guidance. As research evolves, it may emerge as a groundbreaking tool for cognitive enhancement—stay informed through reputable sources like *Examine.com * and peer-reviewed studies
