Ursolic Acid

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  • Ursolic Acid

Short Description:

It is also shown that ursolic acid increased skeletal muscle formation and energy consumption in obesity caused by diet in mice. From these results, it is claimed that the compound might be useful for metabolic disorders such as skeletal muscle atrophy, obesity, type2 diabetes and nonalcoholic fatty liver disease.

Ursolic Acid (UA) is a pentacyclic triterpenoid compound naturally found in plants such as rosemary, loquat leaves, and apples . Historically used as an emulsifier, modern research reveals its broad-spectrum pharmacological activities, including anti-tumor, anti-inflammatory, and metabolic regulation properties .

SanlengBio’s Ursolic Acid 98% stands out with HPLC-validated purity and enhanced bioavailability, achieved through molecular structure optimization (e.g., esterification) to improve lipophilicity and receptor absorption


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
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    Product Detail

    Product Tags

    URSOLIC ACID 98% BY HPLC

    High-Purity Pentacyclic Triterpenoid for Pharmaceutical, Cosmetic, and Nutraceutical Applications

    1. Product Overview

    Ursolic Acid (UA), a naturally occurring pentacyclic triterpenoid, is widely recognized for its multifunctional biological activities, including anti-inflammatory, anti-tumor, and antioxidant properties . SanlengBio’s URSOLIC ACID 98% BY HPLC is manufactured under stringent quality control protocols, ensuring superior purity (>98%) and bioavailability through advanced structural modification technologies . This product complies with international pharmacopeial standards (e.g., USP) and is ideal for research, pharmaceutical formulations, and cosmetic applications.

    2. Chemical & Physical Properties

    2.1 Basic Information

    • CAS No.: 77-52-1 
    • Molecular Formula: C₃₀H₄₈O₃ 
    • Molecular Weight: 456.71 g/mol 
    • Appearance: Fine white to light yellow crystalline powder 
    • Solubility: Soluble in ethanol, methanol, DMF, and DMSO; insoluble in water .

    2.2 Structural Advantages

    SanlengBio’s proprietary esterification technology enhances UA’s lipophilicity, significantly improving intestinal absorption and bioavailability (up to 3-fold increase in receptor uptake) . This modification expands its applicability in drug delivery systems and functional foods.

    3. Specifications & Quality Control

    3.1 Key Parameters

    Parameter Specification Method
    Purity ≥98% (HPLC) HPLC-UV 
    Loss on Drying ≤0.5% (110°C, 1 hr) Gravimetry 
    Residual Solvents Meets ICH Q3C limits GC 
    Isomeric Impurity Oleanolic Acid <0.1% HPLC 

    3.2 HPLC Validation

    • Column: Kinetex® C18 (250 mm × 4.6 mm, 5 µm) 
    • Mobile Phase: 0.1% formic acid (A) / acetonitrile (B) 
    • Detection: UV at 205 nm 
    • Linearity: R² = 0.9996 (0.6–1.8 mg/mL) 
    • Recovery: 102.3% (RSD <1.25%) 

    • 3. Scientifically Validated Benefits

      3.1 Anti-Tumor & Anti-Cancer Effects

      Ursolic Acid inhibits tumor proliferation by:

      • Suppressing NF-κB Signaling Pathways, reducing inflammation-driven carcinogenesis .
      • Inducing Apoptosis in breast, colon, and liver cancer cells via mitochondrial pathway activation .
      • Anti-Angiogenic Activity, blocking tumor vascularization .

      Clinical Relevance: Studies show UA enhances chemotherapy efficacy while reducing side effects .

      3.2 Anti-Inflammatory & Immunomodulatory Actions

      • Topical Application alleviates skin inflammation and accelerates wound healing .
      • Oral Supplementation reduces systemic inflammation markers (e.g., TNF-α, IL-6) .

      3.3 Metabolic & Cardiovascular Health

      • Anti-Diabetic: Improves insulin sensitivity and reduces hepatic glucose output .
      • Anti-Hyperlipidemic: Lowers LDL cholesterol and triglycerides .
      • Cardioprotective: Prevents arrhythmias and atherosclerosis .

      3.4 Cosmetic & Dermatological Applications

      • Anti-Aging: Stimulates collagen synthesis, reducing wrinkles and UV-induced damage .
      • Antimicrobial: Effective against Staphylococcus aureus and Candida albicans .
      • Hair Health: Promotes follicle growth and reduces dandruff

    4. Applications

    4.1 Pharmaceutical

    • Anti-Tumor Therapy: Inhibits tumor cell proliferation via PI3K/Akt/mTOR pathway modulation .
    • Anti-Inflammatory: Reduces COX-2 and TNF-α expression .
    • Metabolic Health: Improves insulin sensitivity and lipid metabolism .

    4.2 Cosmetics

    • Skin Anti-Aging: Enhances collagen synthesis and scavenges free radicals .
    • Whitening: Inhibits tyrosinase activity .

    4.3 Nutraceuticals

    • Functional Foods: Used in emulsifiers and stabilizers .

    5. Safety & Compliance

    • Storage: -20°C in airtight containers; stable for 24 months .
    • Handling: Use PPE; avoid inhalation or direct contact .
    • Certifications: ISO 9001, GMP, and REACH compliant.

    6. Packaging & Ordering

    • Standard Packaging: 1 kg/aluminum foil bag; 25 kg/drum.
    • Customization: Available for bulk orders (≥100 kg).

    7. Why Choose SanlengBio?

    • Technology Leadership: Patented esterified UA for enhanced bioavailability .
    • Quality Assurance: Dual verification by HPLC and GC-MS .
    • Global Compliance: Tailored documentation for EU/US markets.

    8. References

    1. SanlengBio. (2023). Research on Ursolic Acid Bioavailability .
    2. Sigma-Aldrich. (2022). Ursolic Acid Specifications .
    3. Jieliang. (2024). Rosemary Extract Applications .

    Keywords: Ursolic Acid 98% HPLC, High-Purity Triterpenoid, Anti-Tumor Agent, Bioavailability Enhancement, Cosmetic Ingredient

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