Product Name:Diosmetin 98%
Botanical Source:Citrus aurantium L , Lemon extract
CAS No:520-34-3
Plant Part Used:Fruit
Assay: Diosmetin 98% 99% by HPLC
Colour:Yellow brown to Brown fine powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Natural Lemon Peel Extract Diosmetin: Antioxidant & Multifunctional Bioactive Compound
Harnessing Citrus Power for Health and Wellness
Product Overview
Diosmetin (CAS: 520-34-3) is a natural O-methylated flavone primarily derived from lemon peel (Citrus limon) and other citrus fruits . With a molecular formula of C₁₆H₁₂O₆ and purity ≥98% (HPLC), it appears as a light-yellow powder, soluble in DMSO, ethanol, and acetonitrile . This compound is celebrated for its diverse pharmacological activities, validated by extensive scientific research.
Key Benefits & Applications
1. Potent Antioxidant Activity
Diosmetin exhibits exceptional free radical scavenging capacity, surpassing vitamin C in neutralizing DPPH and ABTS radicals . Its antioxidant efficacy is quantified via the FRAP assay (Ferric Reducing Ability of Plasma), a gold-standard method for measuring antioxidant power . Applications include:
- Dietary supplements to combat oxidative stress .
- Skincare formulations to protect against UV-induced skin aging and enhance collagen density .
2. Anti-Inflammatory & Anti-Cancer Properties
- Inhibits IL-1β-induced inflammation in chondrocytes, showing promise for osteoarthritis treatment .
- Suppresses tumor growth and angiogenesis in melanoma models by modulating CYP1A1/CYP1B1 enzymes and reducing ROS levels .
3. Cardioprotective & Diuretic Effects
- Protects myocardial cells from oxidative damage via activation of Nrf2/HO-1 pathways .
- Demonstrates dose-dependent diuretic activity in animal studies, comparable to furosemide, with minimal side effects .
4. Bone Health & Anti-Osteoporosis
- Regulates bone formation and mitigates subchondral bone loss in OA models .
Technical Specifications
| Parameter | Details |
|---|---|
| Purity | ≥98% (HPLC) |
| Solubility | DMSO (60 mg/mL), Ethanol (17 mg/mL), Water (<1 mg/mL) |
| Storage | 2-8°C in airtight container |
| Safety | Non-hazardous per EU Regulation (EC) No. 1272/2008; safe for research use |
Sustainable Production
Diosmetin is synthesized through eco-friendly extraction from citrus peel waste (e.g., orange albedo), achieving high yields (73% from hesperidin) via hydrolysis and oxidation . This aligns with circular economy principles, reducing agricultural waste .
Why Choose Our Diosmetin?
- Clinically Validated: Backed by in vitro and in vivo studies on anti-inflammatory, anticancer, and antioxidant effects .
- Versatile Applications: Suitable for nutraceuticals, cosmetics, and pharmaceuticals.
- Quality Assurance: Batch-specific COA available, ensuring traceability and compliance
