Product Name:Wogonin Bulk Powder
Other Names:5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
CAS No.:632-85-9
Botanical Source:Scutellaria baicalensis
Assay:98% HPLC
Molecular Weight: 284.26
Molecular Formula: C16H12O5
Appearance:Yellow powder
Particle Size: 100% pass 80 mesh
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Wogonin Powder (CAS: 632-85-9) | COX-2 Inhibitor & Anticancer Flavonoid
High Purity (>98%) | Cell-Permeable | Research-Grade
Key Attributes
- Chemical Formula: C₁₆H₁₂O₅ | Molecular Weight: 284.26
- Source: Naturally derived from Scutellaria baicalensis (Chinese skullcap root)
- Solubility: DMSO (10-50 mM), Ethanol (3 mg/mL) | Solid form stable at -20°C for 3 years
- Targets: COX-2, CDK9, NF-κB, Wnt/β-catenin pathway
Product Description
Wogonin is a cell-permeable, orally active flavonoid with anti-inflammatory, antioxidant, and anticancer properties. It inhibits COX-2 expression by blocking PMA-induced AP-1 activation and suppresses tumor growth in human xenograft models (e.g., colon cancer) . Mechanistically, Wogonin induces G1 phase cell cycle arrest via CDK4/cyclin D1 inhibition and promotes apoptosis by downregulating Mcl-1 through CDK9/RNA Pol II suppression .
In inflammatory models, Wogonin reduces IL-1β-induced cartilage degradation by inhibiting MMP-13 and upregulating COL2A1/ACAN expression . It also protects retinal cells from LPS-induced barrier dysfunction by modulating ZO-1/claudin-1 .
Applications
- Cancer Research: Apoptosis induction in leukemia, sarcoma, and solid tumors .
- Inflammation Studies: COX-2 inhibition, NF-κB pathway modulation .
- Neuroprotection: Antioxidant effects in oxidative stress models .
- Metabolic Research: Regulation of cholesterol and lipid metabolism .
Storage & Safety
- Storage: Powder at -20°C (stable for 3 years); solutions at -80°C (2 years) .
- Safety: H303 (Harmful if swallowed) | For research use only .
