Ikhompawundi yendalo efunyenwe kumaqunube kunye nezinye iziqhamo kunye nemifuno inokunceda ukukhusela isifo se-Alzheimer kunye nezinye izifo ezinxulumene neminyaka yobudala, uphando olutsha lucebisa.
Abaphandi abavela kwiSalk Institute for Biological Studies eLa Jolla, CA, kunye noogxa bafumanisa ukuba ukuphatha iimodeli zemouse zokuguga kunye ne-fisetin kwakhokelela ekunciphiseni ukuhla kwengqondo kunye nokuvuvukala kwengqondo.
Umbhali wophononongo ophezulu uPamela Maher, weCellular Neurobiology Laboratory eSalk, kunye noogxa babo kutshanje banike ingxelo yoko bakufumanisileyo kwiiJenali zeGerontology Series A.
I-Fisetin yi-flavanol ekhoyo kwiintlobo zeziqhamo kunye nemifuno, kuquka i-strawberries, i-persimmons, ii-apula, iidiliya, i-anyanisi kunye ne-cucumber.
I-fisetin ayisebenzi nje njenge-agent enemibala yeziqhamo kunye nemifuno, kodwa uphando luye lwabonisa ukuba i-compound inezakhiwo ze-antioxidant, oku kuthetha ukuba inokunceda ukunciphisa umonakalo weseli obangelwa yi-radicals yamahhala.I-Fisetin nayo ibonakaliswe ukunciphisa ukuvuvukala.
Kwiminyaka eyi-10 edlulileyo, uMaher kunye noogxa baye baqhuba izifundo ezininzi ezibonisa ukuba i-antioxidant kunye ne-anti-inflammatory properties ye-fisetin inokunceda ukukhusela iiseli zengqondo kwimiphumo yokuguga.
Olunye uphando olunjalo, olupapashwe ngo-2014, lwafumanisa ukuba i-fisetin yanciphisa ukulahlekelwa kwememori kwiimodeli zegundane ze-Alzheimer's disease.Nangona kunjalo, olo phononongo lugxininise kwimiphumo ye-fisetin kwiigundane kunye ne-Alzheimer yosapho, apho abaphandi baqaphela kuphela ukuya kwi-3 yeepesenti yazo zonke iimeko ze-Alzheimer's.
Kuphononongo olutsha, uMaher kunye neqela bafune ukufumanisa ukuba i-fisetin ingaba neenzuzo ze-Alzheimer's sporadic, eyona ndlela ixhaphakileyo evela kwiminyaka yobudala.
Ukufikelela kwiziphumo zabo, abaphandi bavavanya i-fisetin kwiimpuku eziye zenziwa ubunjineli bofuzo ukuba buguge ngaphambi kwexesha, okubangele imodeli yegundane yesifo se-Alzheimer's sporadic.
Xa iimpuku eziguga ngaphambi kwexesha zazineenyanga ezi-3 ubudala, zohlulwa zibe ngamaqela amabini.Elinye iqela latyiswa umthamo wefisetin ngokutya kwalo yonke imihla kangangeenyanga ezisi-7, de lafikelela kwiinyanga ezili-10 ubudala.Elinye iqela alizange liwufumane lo mzi.
Iqela lichaza ukuba kwiinyanga ze-10 ubudala, izimo zomzimba kunye neengqondo zeegundane zazilingana nezo ze-2 zeminyaka ubudala.
Zonke iimpuku beziphantsi kovavanyo lokuqonda kunye nokuziphatha kulo lonke uphononongo, kwaye abaphandi bavavanya iimpuku kumanqanaba abamakishi anxulumene noxinzelelo kunye nokudumba.
Abaphandi bafumanisa ukuba iigundane zeenyanga ezili-10 ezingazange zifumane i-fisetin zibonise ukwanda kwamanqaku ahambelana noxinzelelo kunye nokuvuvukala, kwaye zenze kakhulu ngakumbi kwiimvavanyo zokuqonda kuneempuku eziphathwe nge-fisetin.
Kwiingqondo zeempuku ezingaphathwanga, abaphandi bafumanisa ukuba iindidi ezimbini ze-neurons ezidla ngokuchasa ukuvuvukala - i-astrocytes kunye ne-microglia - ngokwenene zazikhuthaza ukuvuvukala.Nangona kunjalo, oku kwakungenjalo kwiimpuku ezineenyanga ezili-10 eziphathwa nge-fisetin.
Ngaphezu koko, abaphandi bafumanisa ukuba indlela yokuziphatha kunye nomsebenzi wokuqonda weempuku eziphathwayo zithelekiseka nezo zeempuku ezingaphathwanga ezineenyanga ezi-3.
Abaphandi bakholelwa ukuba iziphumo zabo zibonisa ukuba i-fisetin inokukhokelela kwisicwangciso esitsha sokukhusela i-Alzheimer's, kunye nezinye izifo ezinxulumene ne-neurodeergenerative.
“Ngokusekwe kumsebenzi wethu oqhubekayo, sicinga ukuba i-fisetin inokuba luncedo njengothintelo kwizifo ezininzi ezinxulumene ne-neurodeergenerative, hayi nje i-Alzheimer's, kwaye singathanda ukukhuthaza ukufunda ngokungqongqo ngayo," utshilo uMaher.
Nangona kunjalo, abaphandi baqaphela ukuba izilingo zeklinikhi zabantu ziyafuneka ukuze kuqinisekiswe iziphumo zabo.Banethemba lokusebenzisana nabanye abaphandi ukuhlangabezana nale mfuno.
“Iimpuku azingobantu, kunjalo.Kodwa kukho ukufana okwaneleyo esicinga ukuba i-fisetin ifuna ukujongwa ngokusondeleyo, kungekuphela nje ekunyangeni iAD [isifo sika-Alzheimer] kuphela kodwa nasekunciphiseni ezinye zeempembelelo zengqondo ezinxulumene nokwaluphala, ngokubanzi.
Ixesha lokuposa: Apr-18-2020