Uphando olutsha lweFisetin

I-Fisetin sisityalo se-flavonoid esikhuselekileyo sesityalo se-polyphenol esifumaneka kwiziqhamo ezininzi kunye nemifuno enokuthi icothise inkqubo yokuguga, inceda abantu ukuba baphile ubomi obunempilo kunye nexesha elide.

Kutshanje i-fisetin iye yaphononongwa ngabaphandi beMayo Clinic kunye ne-Scripps Research Institute kwaye yafumanisa ukuba inokwandisa ubomi ngokumalunga ne-10%, ixela ukuba akukho miphumo emibi kwiimpuku kunye nezifundo zezicubu zomntu, njengoko zipapashwe kwi-EbioMedicine.

Iiseli ze-senescent ezonakeleyo ziyityhefu emzimbeni kwaye ziqokelelana nobudala, i-fisetin yimveliso yendalo ye-senolytic abaphandi bacebisa ukuba bakwazi ukubonisa ngokukhetha kwaye bacofe umva iimfihlo zabo ezimbi okanye iiproteni ezivuthayo kunye / okanye ngokubulala iiseli ze-senescent.

Iimpuku ezinikwe i-fisetin zifikelele kwizandiso kuzo zombini ubomi kunye nezempilo ezingaphezulu kwe-10%.I-Healthspans lixesha lobomi apho basempilweni kwaye bahlala khona, hayi nje ukuhlala.Kumadosi anikiweyo ayephezulu, kodwa engaqhelekanga ngenxa yokungabikho kwe-bioavailability ephantsi ye-flavonoids, umbuzo wawungowokuba iidosi ezisezantsi okanye idosi engaqhelekanga engaphezulu ingavelisa iziphumo.Ngokwethiyori uncedo lokusebenzisa la machiza kukucoca iiseli ezonakeleyo, iziphumo zibonisa ukuba kusekho izibonelelo nasekusetyenzisweni rhoqo.

I-Fisetin isetyenziswe kwizicubu ezinamafutha omntu kuvavanyo lwelebhu ukubona ukuba iya kusebenzisana njani neeseli zomntu hayi nje iiseli zeempuku.Iiseli ze-Senescent zikwazi ukuncitshiswa kwizicubu ezinamafutha omntu, abaphandi bacebisa ukuba kunokwenzeka ukuba basebenze ebantwini, nangona ixabiso le-fisetin kwiziqhamo kunye nemifuno akwanelanga ukuvelisa ezi zibonelelo, izifundo ezongezelelweyo ziyafuneka ukwenza idosi yabantu. .

I-Fisetin inokuphucula umsebenzi womzimba ebudaleni ngokophando olupapashwe kwiNature Medicine.Enye epapashwe kwi-Aging Cell ifumene iiseli ze-senescent zidibene nesifo se-Alzheimer kuphononongo olusisiseko olubonisa iqhinga lokukhusela ekukhuseleni ingqondo kwi-dementia ngokondla iigundane ze-fisetin;iimpuku ezazicwangciswe ngokwemfuzo ukuba ziphuhlise i-Alzheimer zakhuselwa ngamanzi afakelweyo yi-fisetin.

I-Fisetin ichongiwe malunga neminyaka eyi-10 edlulileyo kwaye inokufumaneka kwiziqhamo ezininzi kunye nemifuno kuquka i-strawberries, imango, ii-apula, i-kiwi, iidiliya, iipesika, i-persimmons, i-tomato, i-anyanisi kunye nekhukhamba ngesikhumba;nangona kunjalo owona mthombo uthathwa ngokuba ngamaqunube.Ikhompawundi iphandwa ngokuchasa umhlaza, ukulwa nokuguga, ukuchasana nesifo seswekile, iipropathi ezichasene nokudumba kunye nesithembiso sokugcina impilo yengqondo.

Ngoku iKliniki yaseMayo iphantsi kovavanyo lwe-fisetin, nto leyo ethetha ukuba i-fisetin inokufumaneka ebantwini ukunyanga iiseli zesini kwisithuba seminyaka embalwa ezayo.Uphando lwenziwa ukwenza isongezelelo esiya kwenza kube lula ukufumana izixa zenzuzo ukomeleza impilo njengoko ingeyiyo eyona khompawundi yezityalo ilula ukutyiwa.Isenokwenza kube lula ukomeleza impilo yobuchopho, incede izigulana zestroke ukuba ziphile ngcono kwaye ngokukhawuleza, zikhusele iiseli zemithambo-luvo kumonakalo onxulumene nobudala, kwaye zibe luncedo kwizigulana zeswekile kunye nomhlaza.

I-A4M yokuchaza kwakhona iyeza: UGqr.Klatz uxoxa ngokuQalwa kweyeza lokuChaselela ukuguga, ukusebenzisana noGqr.Goldman kunye neSifo esingapheliyo.