Ngo-1913, isazinzulu saseSweden uNjingalwazi uKylin wafumanisa icandelo elincangathi le-kelp, fucoidan, kwiYunivesithi yaseUppsala.Ikwabizwa ngokuba yi "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", njl., igama lesiNgesi ngu "Fucoidan".Yinto yepolysaccharide enyibilikayo emanzini eyenziwe ngefucose equlethe amaqela e-sulfate.Ifumaneka kakhulu kumphezulu we-algae emdaka (efana nokhula lwaselwandle, i-wakame spores, kunye ne-kelp).Umxholo umalunga ne-0.1%, kwaye umxholo kwi-kelp eyomileyo malunga ne-1%.Yinto esebenzayo yokhula lwaselwandle.
Okokuqala, ukusebenza kwe-fucoidan
IJapan ngoku lelona lizwe linobomi obude emhlabeni.Kwangaxeshanye, iJapan inelona zinga liphantsi lezifo ezingapheliyo.Ngokutsho kweengcali zezondlo, esinye sezona zizathu zibalulekileyo kwimpilo yabantu baseJapan inokunxulumana nokusetyenziswa rhoqo kokutya kolwandle.I-Fucoidan equlethwe kwi-algae emdaka efana ne-kelp yinto esebenzayo kunye nemisebenzi eyahlukeneyo yomzimba.Nangona yafunyanwa nguNjingalwazi uKylin kwi-1913, bekungekho kude kube yi-1996 ukuba i-Fucoidan yapapashwa kwiNkomfa ye-55 ye-Cancer Society yaseJapan.Ingxelo ethi "inokubangela i-apoptosis yeseli yomhlaza" ivuse inkxalabo ebanzi kuluntu lwezemfundo kwaye yabangela ukwanda kuphando.
Okwangoku, uluntu lwezonyango luqhuba uphando ngemisebenzi eyahlukeneyo yebhayoloji ye-fucoidan, kwaye ipapashe amawaka amaphepha kwiijenali zonyango zamazwe ngamazwe, eqinisekisa ukuba i-fucoidan inemisebenzi eyahlukeneyo yezinto eziphilayo, ezifana ne-anti-tumor, ukuphucula i-gastrointestinal tract, kunye ne-antioxidant , Ukuphucula ukugonywa. , i-antithrombotic, uxinzelelo lwegazi oluphantsi, iziphumo ze-antiviral.
(I) I-Fucoidan iphucula ukusebenza kakuhle kwamathumbu
I-Helicobacter pylori yi-helical, i-microaerobic, i-gram-negative bacilli efunwa kakhulu kwiimeko zokukhula.Yeyona kuphela intsholongwane eyaziwayo ngoku ukuba iphila kwisisu somntu.Usulelo lwe-Helicobacter pylori lubangela i-gastritis kunye ne-digestive tract.Izilonda, i-lymphoproliferative gastric lymphomas, njl., zine-prognosis embi yomhlaza wesisu.
Iindlela ze-pathogenic ze-H. pylori zibandakanya: (1) ukunamathela: I-H. pylori inokudlula njenge-mucus layer kwaye ibambelele kwiiseli ze-epithelial zesisu;(2) ukunciphisa i-asidi ye-gastric ukuze kuzuze ukuphila: i-H. pylori ikhupha i-urease, kwaye i-Urea esiswini iyasabela ukuze ivelise igesi ye-ammonia, eyenza i-acidity yesisu;(3) itshabalalisa i-gastric mucosa: I-Helicobacter pylori ikhupha i-VacA i-toxin kwaye igubungele iiseli ezingaphezulu ze-gastric mucosa;(4) ivelisa i-toxin ye-chloramine: igesi ye-ammonia ikhukulisa ngokuthe ngqo i-mucosa yesisu, kunye ne-oksijini esebenzayo Ukusabela kuvelisa i-chloramine enetyhefu ngakumbi;(5) Ibangela impendulo yokuvuvukala: Ukuze ukhusele i-Helicobacter pylori, inani elikhulu leeseli ezimhlophe zegazi liqokelela kwi-gastric mucosa ukuvelisa impendulo yokuvuvukala.
Iziphumo ze-fucoidan ngokuchasene ne-Helicobacter pylori ziquka:
1. Ukuthintela ukwanda kwe-Helicobacter pylori;
Kwi-2014, iqela lophando le-Yun-Bae Kim kwiYunivesithi yeSizwe yaseChungbuk eMzantsi Korea yapapasha uphando olubonisa ukuba i-fucoidan inefuthe elihle kakhulu lokulwa ne-antibacterial, kwaye i-fucoidan kwi-concentration ye-100µg / mL inokuthintela ngokupheleleyo ukwanda kwe-H. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Ukuthintela ukubambelela kunye nokuhlasela kwe-Helicobacter pylori;
I-Fucoidan iqulethe amaqela e-sulfate kwaye inokubophelela kwi-Helicobacter pylori ukuyikhusela ekubambeleleni kwiiseli ze-epithelial zesisu.Ngelo xesha, i-Fucoidan inokuthintela ukuveliswa kwe-urease kwaye ikhusele indawo ene-acidic yesisu.
3. Impembelelo ye-Antioxidant, ukunciphisa imveliso ye-toxin;
I-Fucoidan yi-antioxidant elungileyo, enokuthi ikhuphe ngokukhawuleza i-oxygen free radicals kunye nokunciphisa ukuveliswa kwe-chloramine ye-toxin eyingozi.
4. Impembelelo yokuchasa.
I-Fucoidan inokuthintela umsebenzi we-lectin ekhethiweyo, incedise kunye ne-heparanase, kunye nokunciphisa impendulo yokuvuvukala.(Helicobacter, 2015, 20, 89–97.)
Ukongezelela, abaphandi bafumanisa ukuba i-fucoidan inefuthe elibalulekileyo ekuphuculeni impilo yamathumbu kwaye ineendlela ezimbini zokulungisa i-intestinal: ukuphucula ukuqunjelwa kunye ne-enteritis.
Kwi-2017, iqela lophando elivela kuNjingalwazi uRyuji Takeda we-Kansai University of Welfare Sciences eJapan lenze uphando.Bakhetha izigulane ezingama-30 ezinokuqhinwa kwaye zahlulahlula zibe ngamaqela amabini.Iqela lokulinga lanikwa i-1 g ye-fucoidan kwaye iqela lokulawula lanikwa indawo ye-placebo.Kwiinyanga ezimbini emva kovavanyo, kwafunyaniswa ukuba inani leentsuku ze-defecation ngeveki kwiqela lovavanyo elithatha i-fucoidan liye lanyuka ukusuka kumyinge weentsuku ze-2.7 ukuya kwiintsuku ze-4.6, kwaye umthamo we-defecation kunye nokuthamba kwanda kakhulu.(Ukutya okuSebenzayo kwiMpilo kunye neZifo 2017, 7: 735-742.)
Kwi-2015, iqela likaNjingalwazi uNuri Gueven weYunivesithi yaseTasmania, e-Australia, yafumanisa ukuba i-fucoidan inokuphucula ngokufanelekileyo i-enteritis kwiigundane, kwelinye icala, inokunceda iigundane zibuyisele ubunzima kunye nokwandisa ubulukhuni be-defecation;kwelinye icala, inokunciphisa ubunzima bekholoni kunye ne-spleen.Yehlisa ukudumba emzimbeni.(PLoS ONE 2015, 10: e0128453.)
B) Impembelelo ye-Antitumor ye-fucoidan
Uphando malunga nempembelelo ye-antitumor ye-fucoidan ngoku yeyona nto ixhalabileyo kwizangqa zezemfundo, kwaye uninzi lweziphumo zophando zifunyenwe.
1. Ukulawulwa kwe-tumor cell cycle
Ngo-2015, uNjingalwazi Lee Sang Hun kunye nabanye kwiYunivesithi yaseSoonchunhyang eMzantsi Korea kunye nabanye abaphandi bafumanisa ukuba i-fucoidan inqanda ukubonakaliswa kwe-cyclin Cyclin kunye ne-cyclin kinase CDK kwiiseli ze-tumor ngokulawula umjikelo wokukhula kweeseli zomhlaza wekholoni yomntu, echaphazela i-mitosis yesiqhelo. iiseli ithumba.Iiseli zethumba ezimileyo kwisigaba sangaphambi kwemitotic kwaye zithintele ukwanda kweseli.(IiNgxelo zeMolecular Medicine, 2015, 12, 3446.)
2.Ukufakwa kwe-tumor cell apoptosis
Ngo-2012, uphononongo olupapashwe liqela lophando lwe-Quan Li kwiYunivesithi yaseQingdao lwafumanisa ukuba i-fucoidan inokuvula umqondiso we-apoptosis yeeseli ze-tumor-Bax apoptosis protein, ibangele umonakalo we-DNA kwiiseli zomhlaza webele, ukuhlanganiswa kwe-chromosome, kwaye yenze i-apoptosis ezenzekelayo yeeseli zethumba., Ithintele ukukhula kweeseli zethumba kwiimpuku.(Plos One, 2012, 7, e43483.)
3.Inhibit i-tumor cell metastasis
Kwi-2015, u-Chang-Jer Wu kunye nabanye abaphandi be-National Taiwan Ocean University bapapashe uphando olubonisa ukuba i-fucoidan inokunyusa i-tissue inhibitory factor (TIMP) inkcazo kunye ne-down-regulate matrix metalloproteinase (MMP) expression, ngaloo ndlela inhibiba i-tumor cell metastasis.(Mar. Iziyobisi 2015, 13, 1882.)
4.Inhibit tumor angiogenesis
Kwi-2015, iqela lophando lwe-Tz-Chong Chou kwiZiko lezoNyango laseTaiwan lifumene ukuba i-fucoidan inokunciphisa ukuveliswa kwe-vascular endothelial growth factor (VEGF), inqanda i-neovascularization of tumors, inqumle ukunikezelwa kwesondlo se-tumor, ilambile i-tumor. ubungakanani obukhulu Vimba ukusasazeka kunye ne-metastasis yeeseli zethumba.(Mar. Iziyobisi 2015, 13, 4436.)
5.Vuselela amajoni omzimba
Ngo-2006, uNjingalwazi Takahisa Nakano weYunivesithi yaseKitasatouniversity yaseJapan wafumanisa ukuba i-fucoidan inokomeleza ukhuseleko lomzimba kwaye isebenzise amajoni omzimba wesigulana ukubulala iiseli zomhlaza.Emva kokuba i-fucoidan ingene kwi-intestinal tract, inokubonwa ngamaseli omzimba, ivelise imiqondiso eyenza i-immune system isebenze, kwaye isebenze iiseli ze-NK, iiseli ze-B, kunye neeseli ze-T, ngaloo ndlela zivelise amajoni omzimba abopha kwiiseli zomhlaza kunye neeseli ze-T ezibulala umhlaza. iiseli.Ukubulawa ngokuthe ngqo kweeseli zomhlaza, ukuthintela ukukhula kweeseli zomhlaza.(Planta Medica, 2006, 72, 1415.)
Ukuveliswa kweFucoidan
Umxholo wamaqela e-sulfate kwisakhiwo se-molecular ye-fucoidan sisalathisi esibalulekileyo esimisela umsebenzi walo we-physiological, kwaye kwakhona umxholo obalulekileyo wobudlelwane bomsebenzi we-fucoidan.Ngoko ke, umxholo weqela le-sulfate yiparameter ebalulekileyo yokuvavanya umgangatho we-fucoidan kunye nobudlelwane bomsebenzi wesakhiwo.
Kutshanje, ilayisenisi yemveliso yokutya ye-fucoidan polysaccharide ekugqibeleni yaqinisekiswa nguLawulo lokuTya kunye neziyobisi kwaye yanikezelwa kwiQingdao Mingyue Seaweed Group, okuthetha ukuba iMingyue Seaweed Group ibilima ngokunzulu ulwandle ngaphezulu kweminyaka engama-50.Fumana isatifikethi esisemthethweni.Kubikwa ukuba iQela le-Mingyue Seaweed liye lakha umgca wokuvelisa i-fucoidan kunye nemveliso yonyaka yeetoni ezili-10.Kwixesha elizayo, iya kunika umdlalo opheleleyo "kwiyeza kunye ne-homology yokutya" kunye nokukhanya kwintsimi yokutya esebenzayo kwishishini elikhulu lezempilo.
IQela leMingyue Seaweed, njengeshishini elivunyiweyo lokuveliswa kokutya kwe-fucoidan, lineminyaka emininzi yamava emveliso.I-fucoidan eveliswe yiyo yimveliso yophuculo lobugcisa ye-kelp concentrate yoqobo / umgubo.Ukusebenzisa i-algae emdaka ekumgangatho ophezulu njengezinto eziluhlaza, ukucocwa ngakumbi kunye nokwahlula okusekwe kwitekhnoloji yendalo, ayiphuculi nje incasa kunye nencasa yemveliso, kodwa ikwanyusa umxholo we-fucoidan polysaccharide (ubunyulu), enokusetyenziswa kwi iindawo ezininzi ezifana nokutya okusebenzayo kunye nokutya okunempilo..Ineenzuzo zokucoceka kwemveliso ephezulu kunye nomxholo ophezulu wamaqela asebenzayo;ukususwa kwesinyithi esinzima, ukhuseleko oluphezulu;ukukhutshwa kwetyuwa emanzini kunye nokuloba, incasa kunye nokuphuculwa kwencasa.
Ukusetyenziswa kweFucoidan
Okwangoku, zininzi iimveliso ze-fucoidan eziphuhlisiwe zaza zasetyenziswa eJapan, eMzantsi Korea, e-United States nakwamanye amazwe, njenge-fucoidan egxininisiweyo eyongezelelweyo, i-fucoidan extract capsules eluhlaza, kunye nokuthambisa i-seaweed super fucoidan.Ukutya okusebenzayo okufana neQingyou Le yeQingyou Leqela leSeaweed, iRockweed Treasure, isiselo seBrown Algae Plant
Kwiminyaka yakutshanje, "iNgxelo ngeSimo seSondlo sabahlali baseTshayina kunye neZifo ezingapheliyo" ibonisa ukuba isakhiwo sokutya sabahlali baseTshayina sitshintshile, kwaye ukuxhaphaka kwezifo ezingapheliyo kuyanda.Iiprojekthi ezinkulu zezempilo ezigxile “ekunyangweni kwezifo” zitsale ingqalelo enkulu.Ukusebenzisa i-fucoidan ekuphuhliseni nasekuveliseni ukutya okusebenzayo ngakumbi kuya kuphonononga ngokupheleleyo ixabiso lenzuzo ye-fucoidan ukunika ubomi kunye nempilo, eyona nto ibaluleke kakhulu ekuphuhliseni "iyeza elinempilo kunye ne-homology yokutya" ishishini lezempilo elikhulu.
Ikhonkco leMveliso: https://www.trbextract.com/1926.html
Ixesha lokuposa: Mar-24-2020