I-Covid-19, okanye enye eyaziwa ngokuba yi-2019-nCoV okanye i-SARS-CoV-2 intsholongwane, yeyosapho lwe-coronavirus.Njengoko i-SARS-CoV-2 iyeye-β genus Coronavirus inxulumene ngokusondeleyo ne-MERS-CoV kunye ne-SARS-CoV - ekuye kwaxelwa ukuba ibangela iimpawu ezinzima zenyumoniya kwizibetho zangaphambili.Ulwakhiwo lwemfuza ka-2019-nCoV luphawulwe kwaye lwapapashwa.[i] [ii] Iiproteni eziphambili kule ntsholongwane kunye nezo zachongwa ngaphambili kwi-SARS-CoV okanye i-MERS-CoV zibonisa ukufana okuphezulu phakathi kwazo.
Ubutsha bolu hlobo lwentsholongwane kuthetha ukuba kukho ukungaqiniseki okuninzi okujikeleze indlela yokuziphatha kwayo, ke ngoko kuselithuba kakhulu ukufumanisa ukuba izityalo zezityalo okanye iikhompawundi zinokuba negalelo kuluntu njengee-prophylactic agents okanye njengezinto ezifanelekileyo kumachiza okulwa ne-coronavirus ngokuchasene ne-Covid. -19.Nangona kunjalo, ngenxa yokufana okuphezulu kwe-Covid-19 kunye neentsholongwane ezichazwe ngaphambili ze-SARS-CoV kunye ne-MERS-CoV, uphando olupapashiweyo lwangaphambili malunga neekhompawundi zezityalo, eziye zangqinwa ukuba zineziphumo ezichasene ne-coronavirus, inokuba sisikhokelo esixabisekileyo sokufumana i-anti-coronavirus. izityalo zemifuno, ezinokusebenza ngokuchasene nentsholongwane ye-SARS-CoV-2.
Emva kokuqhambuka kwe-SARS-CoV, eyaqala ukuxelwa ekuqaleni kuka-2003[iii], izazinzulu ziye zazama ngamandla ukuxhaphaza iikhompawundi ezininzi ze-antiviral ngokuchasene ne-SARS-CoV.Oku kukhokelele iqela leengcaphephe e-China ukuba lihlole ngaphezulu kwe-200 yamayeza aseTshayina atsalwayo kwimisebenzi yokulwa neentsholongwane ezichasene nolu hlobo lwe-coronavirus.
Phakathi kwezi, izicatshulwa ezine zibonise iziphumo eziphakathi ukuya kwezinamandla zokunqanda ngokuchasene ne-SARS-CoV-i-Lycoris radiata (I-Red Spider Lily), i-Pyrrosia lingua (i-fern), i-Artemisia annua (umhlonyane oswiti) kunye ne-Lindera aggregate (isihlahla esinevumba elimnandi elihlala liluhlaza losapho lwe-laurel. ).Iimpembelelo ezichasene nentsholongwane yezi zinto bezixhomekeke kwidosi kwaye zisuka kwiindawo ezisezantsi zesicatshulwa ukuya phezulu, zihluka kwisicatshulwa ngasinye semifuno.Ngokukodwa iLycoris radiata ibonise owona msebenzi unamandla wokuchasana nentsholongwane egazini. [iv]
Esi siphumo sasihambelana neso samanye amaqela amabini ophando, aphakamisa ukuba indawo esebenzayo equlethwe kwiingcambu zeLicorice, iGlycyrrhizin, ibonakaliswe ukuba inomsebenzi ochasayo we-SARS-CoV ngokuthintela ukuphindaphinda kwayo.[v] [vi] Kwelinye icala. Uphononongo, iGlycyrrhizin ikwabonise umsebenzi we-antiviral xa ivavanyelwa iziphumo zayo ze-in vitro antiviral kwiindawo ezili-10 ezahlukeneyo zeklinikhi ze-SARS coronavirus.I-Baicalin – inxenye yesityalo i-Scuttelaria baikalensis (Skullcap) – nayo iye yavavanywa kolu phononongo phantsi kweemeko ezifanayo kwaye ikwabonise inyathelo lokuthomalalisa intsholongwane ye-SARS. -1 intsholongwane ye-in vitro kwizifundo zangaphambili.[viii] [ix] Nangona kunjalo kufuneka kuqatshelwe ukuba iziphumo ze-in vitro zisenokungahambelani kunye nokusebenza kwekliniki kwi-vivo.Oku kungenxa yokuba idosi yomlomo yezi arhente ebantwini ayinakufezekisa ugxininiso lweserum yegazi efana naleyo ivavanyiweyo kwi-vitro.
I-Lycorine ikwabonakalise inyathelo elinamandla le-antiviral ngokuchasene ne-SARS-CoV.3 Iingxelo ezininzi zangaphambili zibonisa ukuba i-Lycorine ibonakala inemisebenzi yokulwa neentsholongwane ezibanzi kwaye kuxelwe ukuba ibonise isenzo sokuthintela kwi-Herpes Simplex virus (uhlobo I)[x] kunye nePoliomyelitis. intsholongwane kwakhona.[xi]
"Amanye amayeza ekuye kwaxelwa ukuba abonise umsebenzi wokulwa ne-SARS-CoV yiLonicera japonica (iHoneysuckle yaseJapan) kunye nesityalo esaziwayo seEucalyptus, kunye nePanax ginseng (ingcambu) ngendawo yayo esebenzayo iGinsenoside-Rb1."[xii]
Ubungqina obuphuma kolu phando lukhankanywe ngasentla kunye nolunye uphando lwehlabathi lonke lunika ingxelo yokuba uninzi lwamayeza eyeza abonise imisebenzi yokulwa ne-coronavirus [xiii] [xiv] kwaye eyona ndlela iphambili yokusebenza kwayo ibonakala ngathi kukuthintelwa kokuphindaphindeka kwentsholongwane. [xv] China usebenzise kakhulu amayeza esintu aseTshayina kunyango lwe-SARS ngempumelelo kwiimeko ezininzi.[xvi] Nangona kunjalo akukho bungqina bubambekayo malunga nokusebenza kwezi kliniki kwizigulana ezosulelekileyo yi-Covid-19.
Ngaba ezo zicatshulwa zemifuno zinokuba ngabaviwa abanokubakho kuphuhliso lwamayeza amatsha athomalalisa iintsholongwane kuthintelo okanye kunyango lwe-SARS?
INKCAZELO: Eli nqaku libhalelwe injongo yolwazi kuphela kwaye ayenzelwanga ukuthatha indawo yengcebiso yezonyango, ukuxilongwa okanye unyango.Ukuba ucinga ukuba uneempawu ezinxulumene nezo ze-Covid-19 okanye nasiphi na esinye isifo, fowunela ugqirha wakho ngoko nangoko.
[I] Zhou, P., Yang, X., Wang, X. et al., 2020. Ukuqhambuka kwenyumoniya okunxulunyaniswa nekoronavirus entsha enemvelaphi yelulwane.Indalo 579, 270-273 (2020).https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC kunye noGarry, RF, 2020. Imvelaphi esondeleyo ye-SARS-CoV-2.UbuNyango beNdalo, iphe.1-3.
[iii] ixesha leempendulo zeCDC SARS.Ifumaneka apha https://www.cdc.gov/about/history/sars/timeline.htm.Ifikeleleke
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG kunye noLi, RS, 2005. Ukuchongwa kweekhompawundi zendalo ezineentshukumo zokuthomalalisa iintsholongwane ezichasene ne-coronavirus ehambelana ne-SARS.Uphando lwe-Antiviral, i-67 (1), iphepha 18-23.
[v] Cinatl, J., Morgenstem, B. kunye noBauer, G., 2003. I-Glycyrrhizin, inxalenye esebenzayo yeengcambu ze-licorice kunye nokuphindaphinda kwe-coronovirus ehambelana ne-SARS.Lancet, 361 (9374), iphepha 2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW kunye neCinatl, J., 2005. Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS− ICoronavirus.Ijenali yekhemistri yonyango, i-48 (4), iphe.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW kunye noGuan, Y., Ngo-2004. Ukuchaphazeleka kwe-in vitro ye-10 yeklinikhi yodwa ye-SARS coronavirus kwiikhompawundi ezikhethiweyo ze-antiviral.Ijenali yeClinical Virology, 31 (1), iphepha 69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. kunye neTokunaga, T., 1998. Baicalin, inhibitor of HIV-1 imveliso in vitro.Uphando lwe-Antiviral, i-37 (2), iphe.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW kunye noWang, JM, 2000. I-Flavonoid baicalin inqanda ukusuleleka kwe-HIV-1 kwinqanaba lokungena kwentsholongwane.Unxibelelwano lwe-Biochemical kunye nophando lwe-biophysical, i-276 (2), iphe.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. and Kobayashi, S., 1989. Isiphumo se-alkaloids ehlukanisiwe ne-Amaryllidaceae kwi-herpes simplex virus.Uphando kwi-virology, i-140, iphe.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. kunye ne-Alderweireldt, F., 1982. Ii-arhente ze-antiviral.III.Ukwahlukaniswa kwealkaloids kwiClivia miniata Regel (Amaryl-lidaceae).Ijenali yeeMveliso zeNdalo, i-45 (5), iphe.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. kunye noLiang, FS, 2004 Iimolekyuli ezincinci ezijolise kakhulu kwi-coronavirus yabantu.Iinkqubo zeNational Academy of Sciences, 101 (27), iphe.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS kunye neHou, CC, 2007. Specific Izityalo ze-terpenoids kunye ne-lignoids zinemisebenzi enamandla yokulwa neentsholongwane ezichasene ne-coronavirus ebukhali yokuphefumla.Ijenali yekhemistri yonyango, i-50 (17), iphe.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW kunye neTowers, GHN, 1995. Ukuhlolwa kwe-Antiviral yezityalo zonyango zaseBritish Columbian.Ijenali ye-Ethnopharmacology, i-49 (2), iphepha 101-110.
[xv] I-Jassim, i-SAA kunye ne-Naji, MA, 2003. Ii-arhente ze-antiviral ezinoveli: imbono yesityalo samayeza.Ijenali ye-microbiology esetyenzisiweyo, i-95 (3), iphepha 412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. kunye noLiu, JP, 2020. Ingaba iyeza laseTshayina lingasetyenziselwa ukuthintela isifo sentsholongwane ye-Corona ngo-2019 (COVID-19) -19)?Uphononongo lweeklasikhi zembali, ubungqina bophando kunye neenkqubo zangoku zokuthintela.Ijenali yaseTshayina ye-Integrative Medicine, iphe.1-8.
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Ixesha lokuposa: Apr-18-2020