Iithegi ezinxulumeneyo: impilo yentliziyo, ukungaphumeleli kwentliziyo, umsebenzi wepqq sanitize_gpt_value2(gptValue) {var vOut=""; var aTags = gptValue.split(','); var reg = iRegExp entsha ('\\W+', "g" (var i=0; i"Njenge-organelle ebalulekileyo yokugcina ukusebenza kwentliziyo, i-mitochondria inika amandla kuyo yonke intliziyo.Kukho ubungqina obuninzi bokuba i-mitochondria zizityalo zamandla zentliziyo.Nangona kunjalo, njengeebhetri ezindala, intliziyo yezigulana ezinokusilela kwentliziyo engapheliyo ekugqibeleni ziya kuphelelwa.“Ngokophando olusanda kupapashwa.
Kuba i-pyrroloquinoline quinone (PQQ) ithathwa njenge-antioxidant cofactor esebenzayo kwinkqubo yokunciphisa kunye ne-oxidation, isasazwa ngokubanzi kwizicubu zezilwanyana kunye nezityalo.Kuyimfuneko kwizilwanyana ezanyisayo ekuswelekeni kwe-PQQ kuchaphazela i-mitochondria kunye nomsebenzi we-mitochondrial kwezi ntlobo.Yezondlo.
Nangona i-PQQ iqulethe iipropathi ezinjenge-vitamin, ithathwa njengesondlo.Abagqugquzeli be-enzyme banempembelelo ethile ye-antioxidant, efumaneka ngokuqhelekileyo kwi-kiwi, i-pepper eluhlaza kunye ne-parsley.Abantu abaninzi bathatha i-PQQ ngokusebenzisa izongezo.
Enye yezona ziphumo zibalulekileyo ze-PQQ kwi-mitochondria.I-Mitochondria ibonelela ngeeseli zethu ngamandla (ATP) kunye nokulawula i-cell metabolism.Abaphandi baye bafunda ngokubanzi iziphumo ze-PPQ kwi-mitochondria kwaye bafumanisa ukuba i-PQQ inokunyusa inani kunye nokusebenza kakuhle kwe-mitochondria.
Ukuze uhlolisise unyango olutsha lokungaphumeleli kwentliziyo engapheliyo, umboneleli wezondlo zesondlo kunye nomenzi weSayensi yezeMpilo ye-Nascent kutshanje usebenzisane neSebe leCardiology yeSibhedlele seYunivesithi yaseNantong e-China ukufunda umphumo we-PQQ ekuphuculeni ukusebenza kwentliziyo.
Ngokukodwa, uphononongo luphande isiphumo se-PQQ ekusebenzeni kwe-mitochondrial kwimodeli yoxinzelelo lwentliziyo, kwaye yaphanda ukuba i-PQQ inokuphucula ukusebenza kwentliziyo kwaye incede ukuthintela ukusilela kwentliziyo okungapheliyo.
Ukumisela umphumo we-PQQ kwisifo senhliziyo esingapheliyo kunye nokusebenza kwekhontrakthi emzimbeni, iigundane ezineveki ze-6 zenziwa utyando lwe-sham yeeveki ze-12 okanye utyando lwe-transaortic coarctation (TAC), kwaye zanikwa i-0.4, i-2 okanye i-10 mg / kg imihla ngemihla ye-PQQ. .
Emva kweeveki ezili-12 ze-TAC, iigundane zabonisa i-ventricular ebalulekileyo kunye ne-muscle cell hypertrophy kunye nokwandisa ubunzima bentliziyo / ubunzima bomzimba.
Umbhali uphinde wabonisa ukuba iziphumo zophando "zibonisa ukuba i-2 kunye ne-10 mg / kg ye-PQQ inemiphumo emihle yonyango;nangona kunjalo, xa kuthelekiswa ne-2 mg / kg ye-PQQ, i-10 mg / kg i-PQQ ayibonisi umphumo oxhomekeke kugxininiso, ngelixa i-2 mg / kg i-PQQ ayibonisi umphumo oxhomekeke kugxininiso.Ke ngoko, i-PQQ yeyona thamo ilungileyo yonyango phakathi kwamaqela amathathu.Kolu vavanyo lulandelayo, iqela lonyango lwe-TAC + PQQ lanikwa 2 mg/kg PQQ.”
Ngokusekelwe kwezi ziphumo, umbhali ubonisa ukuba ukudibanisa kwazo zonke izinto kunokunceda ukukhusela ukwenzeka kwentliziyo engapheliyo.
"Ngokokuqala ngqa kwimbali, i-PQQ enamandla ye-antioxidant ibonise izibonelelo ezilungileyo ze-myocardial mitochondrial dysfunction kunye ne-CHF," kusho uThomas Schrier, uSekela Mongameli weNtengiso, iSayensi yezeMpilo yeNascent.“Abaphandi kwiYunivesithi yaseNantong bajonge ngokukodwa unyango lwe-cardiac mitochondrial function, kwaye ngoku bafumene ubungqina obubambekayo bokuba isakhono se-PQQ sokuvuselela i-mitochondrial biogenesis inokuthintela umonakalo wentliziyo kunye nokukhuthaza impilo yentliziyo.”
"I-Pyrroloquinoline quinone inokuthintela ukungaphumeleli kwentliziyo ngokulawula ukusebenza kwe-mitochondrial"
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Ixesha lokuposa: Sep-01-2021