"Uphononongo lwethu luhlolisise indlela yokwenza i-PEA isebenzisa umzekelo omiselweyo wentlungu kumavolontiya aphilileyo ukuze aqonde ngakumbi iindlela ezibandakanyekayo, ezibaluleke kakhulu ekuhlukaniseni unyango kunye nokuphuhlisa iindlela zonyango ezisekelwe kumatshini," abaphandi babhala.IYunivesithi yaseGraz, exhase isifundo ngemali.
Kuphononongo olupapashwe kwiphephancwadi elikhethekileyo leNutrition, iMida kwiDiet kunye neZifo eziPhambili: Ukuqhubela phambili okutsha kwi-Fibrosis, ukuvuvukala kunye neentlungu, i-PEA ibonwa njengenye indlela yokusetyenziswa kweyeza zentlungu ezifana ne-NSAID kunye ne-opioids.
Iqale yodwa kwiimbotyi zesoya, izikhupha zeqanda kunye nomgubo wepeanut, i-PEA iyikhompawundi yokulinganisa i-cannabis eyenzeka ngokwemvelo emzimbeni ekuphenduleni ukulimala kunye noxinzelelo.
"I-PEA ine-analgesic ebanzi, i-anti-inflammatory, kunye ne-neuroprotective action, eyenza i-agent enomdla yonyango lwentlungu," abaphandi bathi.
"Uhlalutyo lwakutshanje lwe-meta lwezifundo ezisebenzisa i-PEA kwiintlungu ze-neuropathic okanye ezingapheliyo zibonise ukusebenza kweklinikhi.Nangona kunjalo, inkqubo esisiseko yokuthomalalisa iintlungu ayizange ifundwe ebantwini.”
Ukufunda indlela yokusebenza kwe-PEA, abaphandi baye bachonga iindlela ezintathu eziphambili, kubandakanywa uvakalelo lwe-peripheral, uvakalelo oluphakathi, kunye nokuguqulwa kweentlungu.
Kule ndawo, i-placebo-controlled, i-double-blind-blind, i-cross-over study, amavolontiya e-14 anempilo afumana i-400 mg PEA okanye i-placebo kathathu ngosuku kwiiveki ezine.Inkampani yaseDatshi i-Innexus Nutraceuticals ibonelele nge-PEA, kwaye i-placebo yaveliswa yi-Institutional Pharmacy ye-Medical University yaseGraz.googletag.cmd.push(umsebenzi () {googletag.display('text-ad1′); });
Emva kwexesha lovavanyo lweentsuku ze-28, abaphandi balinganisa imiphumo yokulawulwa kweentlungu eziphantsi, uxinzelelo lweentlungu, kunye nokunyamezela kweentlungu ezibandayo ngokusekelwe kwimilinganiselo yesiseko.Ukungeniswa kwexesha elifutshane le-peripheral kunye ne-central sensitization, kunye nokufunda i-analgesic kunye ne-antihyperalgesic effects, imodeli yentlungu evunyiweyo "i-repetitive phase heat compress" isetyenziswe.Emva kwexesha le-8-iveki yokuhlamba, imilinganiselo emitsha yesiseko yathathwa iintsuku ze-28 ngaphambi kokuba abathathi-nxaxheba batshintshelwe kwamanye amanyathelo okufunda.
Abathathi-nxaxheba kwiqela le-PEA babonise ukunciphisa okuphawulekayo kwiintlungu eziphindaphindiweyo zokushisa, isantya esijijayo, kunye nomgama ophakathi ukuya kwi-allodynia (intlungu ebangelwa yi-stimuli engenabuhlungu), ngokuphawulekayo ukunyamezela iintlungu ezibandayo, kunye nokunyuka kokunyamezela intlungu kwi-heat pain sensitivity and susceptibility.
"Uphononongo lwangoku lubonisa ukuba i-PEA ineempawu ezifanelekileyo zeklinikhi ze-analgesic ngokusebenza kwiinkqubo ze-peripheral kunye ne-central kunye ne-modulating pain," abaphandi baphetha.
Uphononongo lubonisa ukuba izilingo ezongezelelweyo ziya kuphonononga ukusebenza kwayo kwizigulane ezine-conditioned pain modulation disorder, ukudakumba, okanye i-fibromyalgia ephakathi.
"Idatha yethu iphinda ixhase ukusebenza kwe-PEA njenge-prophylactic pain reliever," abaphandi bongezelela."Le ndlela inokuphononongwa ngakumbi kuphando oluzayo, umzekelo kunyango kunye nokuthintela intlungu eqhubekayo emva kokuhlinzwa."
Izondlo 2022, 14 (19), 4084doi: 10.3390 / nu14194084 "Impembelelo ye-palmitoylethanolamide kwintlungu ebuhlungu, uvakalelo oluphakathi kunye ne-peripheral, kunye nokuguqulwa kweentlungu kumavolontiya anempilo - i-randomized, i-double-blind-blind-blind-blind, i-placebo Kordula Lang-Ilievich et al.
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Ixesha lokuposa: Jul-26-2023