Azelaic Acid 98%nipa HPLC | Elegbogi & Ite Kosimetik
1. ọja Akopọ
Azelaic acid(CAS123-99-9) jẹ dicarboxylic acid ti o kunju ti o nwaye nipa ti ara pẹlu agbekalẹ molikula C₉H₁₆O₄ ati iwuwo molikula 188.22 g/mol. Ijẹrisi mimọ HPLC wa 98% ni ibamu pẹlu awọn iṣedede USP/EP, iṣapeye fun awọn agbekalẹ dermatological ati awọn ohun elo ile-iṣẹ.
Awọn pato bọtini
- Mimo: ≥98% (HPLC-ELSD ti a fọwọsi, lapapọ awọn aimọ <0.2%)
- Irisi: White crystalline lulú
- Oju Iyọ: 109-111°C
- Ojuami Sise: 286°C ni 100 mmHg
- Solubility: 2.14 g / L ninu omi (25 ° C), tiotuka ni ethanol / ipilẹ awọn solusan
2. Kemikali Abuda
2.1 Igbekale Ijeri
- NMR Profaili:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H kọọkan), 1, 2H COOH) - Chromatogram HPLC:
Aago Idaduro: Awọn iṣẹju 20.5 (tente akọkọ), awọn oke alaimọ <0.1% ni 31.5/41.5 min
2.2 Didara Iṣakoso Ilana
| Paramita | Ọna | Awọn Ilana gbigba |
|---|---|---|
| Ayẹwo | HPLC-ELSD (Agilent 1200) ọwọn: Purospher Star RP-C18 Ipele Alagbeka: kẹmika / Omi / Acetic Acid gradient | 98.0-102.0% |
| Awọn irin Heavy | ICP-MS | ≤10 ppm |
| Awọn ohun elo ti o ku | GC-FID (HP-5MS ọwọn) Iyatọ pẹlu HMDS | Ethanol <0.5% |
3. Awọn ohun elo elegbogi
3.1 Ẹkọ nipa iwọ-ara
- Irorẹ vulgaris:
Din comedones dinku nipasẹ 65% ni awọn idanwo ọsẹ mejila (20% ipara) nipasẹ:- Antimicrobial igbese lodi siC. irorẹ(MIC₅₀ 256 μg/ml)
- Idilọwọ Tyrosinase (IC₅₀ 3.8 mM) fun hyperpigmentation post-iredodo
- Rosacea:
15% jeli fihan 72% idinku ninu erythema (vs 43% placebo) nipasẹ:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- Imukuro MMP-9 ni keratinocytes
3.2 Ilana Ilana
| Fọọmu iwọn lilo | Ti ṣe iṣeduro% | Awọn akọsilẹ ibamu |
|---|---|---|
| Ipara/Geli | 15-20% | Yago fun methylparaben (o fa ibajẹ 42%) |
| Liposomal | 5-10% | Lo phosphate buffer pH7.4 + soybean lecithin |
4. Awọn ohun elo ikunra
4.1 Whitening Synergy
- Awọn akojọpọ to dara julọ:
- 2% AzA + 5% Vitamin C: 31% idinku melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x kolaginni igbelaruge
4.2 data iduroṣinṣin
| Ipo | Oṣuwọn ibajẹ |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Ifihan UV | 1.2% (pẹlu aabo TiO₂) |
5. Industrial Nlo
- Polymer Precursor:
- Nylon-6,9 kolaginni (ikore esi> 85% ni 220°C)
- Idalọwọduro ibajẹ fun awọn ohun elo irin (ojutu 0.1M dinku ibajẹ nipasẹ 92%)
6. Aabo & Ilana
6.1 Profaili Toxicological
| Paramita | Abajade |
|---|---|
| Oral LD₅₀ (Eku) | > 5000 mg / kg |
| Ibanujẹ awọ ara | Ìwọ̀nba (OECD 404) |
| Ewu Ocular | Ẹka 2B |
6.2 Agbaye ibamu
- Awọn iwe-ẹri:
- US FDA Drug Titunto File
- EU REACH Iforukọsilẹ
- ISO 9001: 2015 Didara Eto
7. Iṣakojọpọ & Ibi ipamọ
| Opoiye | Apoti | Iye owo (EXW) |
|---|---|---|
| 25 kg | HDPE ilu + Alu apo | $4,800 |
| 1 kg | Amber gilasi igo | $220 |
| 100 g | Apo ti a fi edidi meji | $65 |
Ibi ipamọ: 2-8°C ni agbegbe gbigbẹ (iwọn itẹwọgba yara ti <25°C/60% RH)
8. FAQs
Q: Ṣe MO le lo azelaic acid pẹlu niacinamide?
A: Bẹẹni, data ile-iwosan fihan 10% AzA + 4% niacinamide ṣe ilọsiwaju ifarada 37% vs AzA nikan
Q: Kini igbesi aye selifu?
A: Awọn oṣu 36 nigbati o fipamọ daradara. Ipele-pato COA ti a pese
9. Awọn itọkasi
- NMR data karakitariasesonu
- HPLC-ELSD ilana
- Awọn ẹkọ iduroṣinṣin
- Isẹgun ipa
