I-10-deacetylbaccatin III (10-dab)

I-10-deacetylbaccatin III (10-Dab) isithombe esifakiwe
  • I-10-deacetylbaccatin III (10-dab)

Incazelo emfushane:

I-10-deacetylbaccatin III (C29h336O10) iyi-bikoactive diterpenoid ngokwemvelo ekhishwe ngezinaliti kanye namagxoloFakaizinhlobo (izihlahla ze-yew). Njengomsunguli osemqoka ku-semi-synthesis we-paclitaxel, i-doctetaxel, nakwamanye ama-cheetape-based chemotherapeutic agents, ama-10-dab asetshenziswa kabanzi ekukhiqizweni kwezidakamizwa kwe-R & D kanye ne-Oncology.

I-10-deacetylbaccatin III, eyaziwa nangokuthi yi-10-dab noma i-10-dab III, iyizinhlanganisela zemvelo ezihlobene kakhulu nezinaliti ze-European Lew Docters (TapeTere). pacitaxel (i-tandol); I-cabahazitaxel. I-10-10-DEACETYLBBACCATIn III yatholakala ukuthi ikhulisa ngokukhetha ukukhula kwe-L. Donvovani Intracellular Ama-J774 Murne Macrophages eVitro ekugxileni kwe-nanomolar nge-IC (50) inani lama-70 nm.


  • Intengo ye-FOB:I-US 5 - 2000 / kg
  • Min.ORDORDER MING:1 kg
  • Ukuhlinzekela amandla:I-10000 kg / ngenyanga
  • IPort:Shanghai / Beijing
  • Imibandela Yokukhokha:L / C, D / A, D / P, T / T, A
  • Imibandela Yokuthumela:Ngolwandle / nge-air / nge-courier
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    Igama lamakhemikhali: I-10-deacetylbaccatin III

    Inombolo ye-CAS:

    32981-86-5
    Izimpawu:

    I-10-desacetylbaccatin III; I-10β-deacetylbaccatin III; (2ar, 4s, 4S, 6r, 9s, 11s, 12s, 12, 12BS, 12BS, I-ECAHYDRO-4,6,9,11-Tetrahydroxy-4a, 8,13,13-Tetramethyl-7,11-Methano-5,1] I-CYCLECY - 5,2] Oket-5-One; 7,11-Methano-5,4] I-BENT-5-ONE, I-12b- (acetyloxy) -12- (benzoyloxy) -1,2A, 3,4,4a, 6,9,4a, 6,9,12, 12b-Dodecahydro-4,6,9,11-Tetrahydroxy-4, (2ar, 4s, 4S, 6r, 9s, 11s, 12s, 12ar, 12bs) -; (Ukungcola kwe-epp);I-10-deacetylbaccatin III; I-10-deacetyl baccatin; . I-12b-dodecahydro-4,6,9,111,120-hexahydroxy-4a, 8,13,13-Tetramethyl-5,11-Methano-5,11-CYCLETECHER-5,2] I-12b-acetate, 12-benzoate (usp);
    Ifomu lamaMolelisar: C29h366O10
    Ukubukeka: Okumhlophe okuqinile
    Mol. Isisindo: 544.6
    Isitoreji: 2-8 ° C Isiqandisi

    Isihlokwana: I-API ethathwe i-API Iphakathi, i-CAS 32981-86-5 | I-GMP eqinisekisiwe, i-COA enikeziwe

    Yini i-10-deacetylbaccatin III (I-10-dab)?

    I-10-deacetylbaccatin III (C29h336O10) iyi-bikoactive diterpenoid ngokwemvelo ekhishwe ngezinaliti kanye namagxoloFakaizinhlobo (izihlahla ze-yew). Njengomsunguli osemqoka ku-semi-synthesis we-paclitaxel, i-doctetaxel, nakwamanye ama-cheetape-based chemotherapeutic agents, ama-10-dab asetshenziswa kabanzi ekukhiqizweni kwezidakamizwa kwe-R & D kanye ne-Oncology.

    Ukucaciswa Okubalulekile Nezinto

    • Ukumsulwa: ≥98% (I-HPLC-UV iqinisekisiwe, COA iyatholakala)
    • Ukubukeka: Okumhlophe Kwimputha Emhlophe-White Crystalline Powder
    • I-Solubity: incibilika eMethanol, ethanol, DMSO; incane kancane emanzini
    • Isitoreji: ezinzile ku-20 ° C ezitsheni zezindiza, ezivikelwe ukukhanya
    • Umthombo Wezitshalo: Kuvunwe KakhuluAmatekisi Wallichiana(I-Himalayan yew)

    Izicelo ze-10-dab

    1. Ukuhlanganiswa kwezidakamizwa kwezikhali
      • Umphakathi obucayi wokukhiqizwa kwe-paclitaxel (taxOL®) kanye ne-DoCoteTaxel (tafeTere®).
      • Isetshenziswa ku-R & D yenoveli terane derivativeves okubhekiswe kumdlavuza ongazweli emithini.
    2. Ucwaningo lwe-Biochemical
      • Ukutadisha kwezindlela ze-tubulin polymerization kanye nokungeniswa kwe-apoptosis.
      • I-Reference Standard ye-Analytical Chemistry kanye nokulawulwa kwekhwalithi.
    3. Ukukhishwa komkhiqizo wemvelo
      • Inqubo yokukhipha isithembi esiphezulu ehambisana nemigomo ye-Green Chemistry.

    Kungani Umthombo 10-Dab kithi?

    Ikhwalithi eqinisekisiwe:

    • Isitifiketi sokuhlaziywa kwe-batch (COA) nge-HPLC, MS, idatha ye-NMR.
    • Ukuhambisana ne-USP, EP, kanye ne-ICH Q7 Imihlahlandlela ye-GMP.

    Soustable Sourcing:

    • Ukuvunwa ngokufanele kusuka emasimini ahlakulelwe amatekisi (CITES APPENTIX II Ukuhambisana).

    ✅ I-Global Logistics:

    • Ukuhanjiswa okubandayo okubandayo okubangelwa e-USA, e-EU, nezifunda ze-APAC.
    • Ukupakishwa okwenziwe ngokwezifiso (1g kuya ku-1kg, i-amber glass vials ene-desiccant).

    Ukuxhaswa kwezobuchwepheshe kanye nemibhalo

    • I-MSDS yamahhala (ishidi ledatha yezokuphepha ezibonakalayo) kanye nedatha yokuzinza esicelweni.
    • Ukuhlanganiswa okwenziwe ngokwezifiso kanye namanani entengo ngobuningi atholakala kubalingani be-OEM.
    • Ukuxhaswa kokulawulwa okuzinikezele kwe-IND / NDA okuthunyelwe.

    Ukuphepha nokuhambisana

    • Inombolo ye-CAS: 32981-86-5
    • Amakhodi Anobungozi: Phatha nge-PPE (amagilavu, ama-goggles) - okungeyona ingozi yokusetshenziswa kobungcweti.
    • Isimo Sokulawula: Finyelela Kubhalisiwe; I-DMF etholakala kumakhasimende amakhambi.

    Ama-FAQs we-10-Dab

    Q: Ngabe i-10-dab ingasetshenziswa ngqo ezifundweni zesiko leselula?
    A: Cha. Kudinga ukuguqulwa kwamakhemikhali (isib. Ukungezwa kwe-Side-Chain) ukuze ube ama-tatane e-bioactive.

    Q: Yini isikhathi sokuhola sama-oda angama-500g?
    A: Isikhathi sokukhiqizwa esijwayelekile: amasonto ama-2-3. Ukuthumela okuvezayo kuyatholakala.

    Q: Ngabe uhlinzeka ngezivumelwano ze-taxane synthesis?
    A: Yebo! Ama-Whift Whitepapers atholakala kumakhasimende afanelekayo.

    Incazelo:
    Umthombo 98% I-HPLC-grade 10-deacetylbaccatin III (CAS 32981-86-5) - I-GMP-Certified tables tables ekhishwe nge-paclitaxel synthesis. Ama-oda amaningi, ama-coa / msds, kanye nokusekelwa okulawulwayo kufakiwe.

    1. Amagama agqamile:
      • Okuyisisekelo: "10-Deacetylbaccaccaccatin III umphakeli", "purnity ephezulu 10-dab", "paclitaxel premursor"
      • Umsila omude: "Cas 32981-86-5 intengo", "Ukukhishwa kwamatekisi ocwaningweni lomdlavuza", "GMP 10-Dab"
    2. Amagama agqamile:
      • "I-Taxlemetiate", "i-semi-zokwenziwa paclitaxel", "c29hh36o10," terter Tree Compact "
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