I-10-Deacetylbaccatin III (10-DAB)

Incazelo emfushane:

I-10-Deacetylbaccatin III (C29H36O10) iyi-bioactive diterpenoid ekhishwa ngokwemvelo ezinalitini nasemagxolweniIntelaizinhlobo (izihlahla ze-yew). Njengesandulela esiyinhloko ku-semi-synthesis ye-paclitaxel, i-docetaxel, namanye ama-ejenti e-chemotherapeutic asekelwe ku-taxane, i-10-DAB isetshenziswa kabanzi ekukhiqizeni imithi ye-R&D kanye nokukhiqizwa kwezidakamizwa ze-oncology.

I-10-Deacetylbaccatin III, eyaziwa nangokuthi i-10-DAB noma i-10-DAB III, iyinhlanganisela yemvelo ehlobene eduze kakhulu ehlukaniswe nezinaliti ezomisiwe namagatsha amancane esihlahla se-yew saseYurophu (i-Taxus baccata) . pacitaxel (taxol); cabazitaxel. I-10-10-deacetylbaccatin III itholwe ivimbela ngokukhetha ukukhula kwe-L. DONOVANI intracellular amastigotes ngaphakathi kwe-J774 murine macrophages in vitro ekugxilweni kwe-nanomolar enenani le-IC(50) le-70 nM.

Intengo ye-FOB:US 5 - 2000 / KG

Inani elincane le-oda:1 KG

Ikhono Lokuhlinzeka:10000 KG/ngenyanga

Imbobo:I-Shanghai / Beijing

Imigomo Yokukhokha:L/C,D/A,D/P,T/T,O/A

Imigomo Yokuthumela:Ngasolwandle/Ngemoyeni/Nge-Courier

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Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Igama lekhemikhali:	10-Deacetylbaccatin III
Inombolo ye-CAS:	32981-86-5
Omqondofana:	10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP Ukungcola);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, I-12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one 12b-acetate, 12-acetate (USP-benzo);
Ifomu le-molecular:	I-C29H36O10
Ukubukeka:	Okuqinile Okumhlophe
UMol. Isisindo:	544.6
Isitoreji:	2-8°C Isiqandisi

Umbhalo ongezansi: I-Plant-Derived API Intermediate, CAS32981-86-5| Iqinisekisiwe ye-GMP, i-COA Inikeziwe

Iyini i-10-Deacetylbaccatin III (10-DAB)?

Ukucaciswa Okubalulekile nezici

Ubumsulwa: ≥98% (HPLC-UV iqinisekisiwe, i-COA iyatholakala)
Ukubukeka: I-crystalline powder emhlophe ukuya kokumhlophe
I-Solubility: I-Soluble ku-methanol, i-ethanol, i-DMSO; incibilika kancane emanzini
Isitoreji: Izinzile ku -20°C ezitsheni ezingangeni moya, zivikelekile ekukhanyeni
Umthombo Wezitshalo: Ivunwa ngokuqhubekayoTaxus wallichiana(Yew Himalayan)

Izicelo ze-10-DAB

I-Anticancer Drug Synthesis
- Okumaphakathi okubalulekile kokukhiqizwa kwe-semi-synthetic ye-paclitaxel (Taxol®) ne-docetaxel (Taxotere®).
- Isetshenziswa ku-R&D kokuphuma kwenoveli ye-taxane eqondiswe kumdlavuza ongazweli emthini.
Ucwaningo lwe-Biochemical
- Ucwaningo lwezinqubo ze-tubulin polymerization kanye nokungeniswa kwe-apoptosis.
- Izinga eliyisethenjwa lekhemistri yokuhlaziya nokulawula ikhwalithi.
Ukukhishwa Komkhiqizo Wemvelo
- Inqubo yokukhipha isivuno esiphezulu ihambisana nezimiso zamakhemikhali aluhlaza.

Kungani Umthombo we-10-DAB uvela Kithi?

✅ Ikhwalithi Eqinisekisiwe:

Isitifiketi Sokuhlaziya esiqondene neqoqo (COA) esinedatha ye-HPLC, MS, NMR.
Ihambisana nemihlahlandlela ye-USP, EP, kanye ne-ICH Q7 GMP.

✅ Ukuthola usizo oluqhubekayo:

Ivunwa ngendlela efanele emasimini e-Taxus atshaliwe (ihambisana ne-CITES Appendix II).

✅ Global Logistics:

Ukuthunyelwa kochungechunge olubandayo oluya ezindaweni zase-USA, EU, nase-APAC.
Ukupakishwa okwenziwe ngokwezifiso (1g kuya ku-1kg, izitsha zengilazi ze-amber ezine-desiccant).

Ukwesekwa Kwezobuchwepheshe Nemibhalo

I-MSDS yamahhala (Ishidi Ledatha Yokuphepha Okubalulekile) kanye nedatha yokuzinza lapho ucelwa.
Ukuhlanganiswa kwangokwezifiso nezintengo zenqwaba zitholakala kozakwethu be-OEM.
Ukwesekwa okunikelwe kokulawula kokuthunyelwe kwe-IND/NDA.

Ukuphepha Nokuhambisana

Inombolo ye-CAS: 32981-86-5
Amakhodi Wengozi: Bamba nge-PPE (amagilavu, izibuko) - engeyona ingozi ukusetshenziswa kochwepheshe.
Isimo Sokulawula: REACH ebhalisiwe; I-DMF itholakalela amaklayenti emithi.

I-FAQ ye-10-DAB

Q: Ingabe i-10-DAB ingasetshenziswa ngokuqondile ezifundweni zesiko lamaseli?
IMP: Cha. Idinga ukuguqulwa kwamakhemikhali (isb., ukungezwa kwe-side-chain) ukuze ibe ama-bioactive taxanes.

Q: Yisiphi isikhathi sokuhola sama-oda we-500g?
A: Isikhathi sokukhiqiza esijwayelekile: amaviki angu-2-3. Ukuthunyelwa kwe-Express kuyatholakala.

Q: Ingabe uyawahlinzeka ngamaphrothokholi e-taxane synthesis?
A: Yebo! Amaphepha amhlophe obuchwepheshe atholakalela amaklayenti aqeqeshiwe.

Incazelo:
Umthombo 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - I-GMP-certified Taxus extract for paclitaxel synthesis. Ama-oda amaningi, i-COA/MSDS, nokusekelwa kokulawula kufakiwe.

Amagama angukhiye:
- Okuyinhloko: “10-Deacetylbaccatin III umphakeli”, “High purity 10-DAB”, “Paclitaxel precursor”
- Umsila omude: "intengo ye-CAS 32981-86-5", "I-Taxus ekhishwe ucwaningo lomdlavuza", "GMP 10-DAB"
Amagama angukhiye:
- “Taxane intermediate”, “semi-synthetic paclitaxel”, “C29H36O10″, “yew tree compound”