Inhlanganisela yemvelo etholakala kuma-strawberry nezinye izithelo nemifino ingasiza ekuvimbeleni isifo se-Alzheimer kanye nezinye izifo ezihlobene ne-neurodegenerative ezihlobene neminyaka, ucwaningo olusha luphakamisa.
Abacwaningi abavela ku-Salk Institute for Biological Studies e-La Jolla, CA, kanye nozakwabo bathola ukuthi ukwelapha amamodeli amagundane okuguga nge-fisetin kuholele ekwehleni kokuncipha kwengqondo nokuvuvukala kobuchopho.
Umbhali wocwaningo oluphezulu u-Pamela Maher, we-Cellular Neurobiology Laboratory e-Salk, kanye nozakwabo basanda kubika abakutholile ku-The Journals of Gerontology Series A.
I-Fisetin iyi-flavanol ekhona ezinhlobonhlobo zezithelo nemifino, okuhlanganisa ama-strawberries, ama-persimmons, ama-apula, amagilebhisi, u-anyanisi namakhukhamba.
Akukhona nje ukuthi i-fisetin isebenza njenge-ejenti enemibala yezithelo nemifino, kodwa ucwaningo luye lwabonisa ukuthi i-compound inezakhiwo ze-antioxidant, okusho ukuthi ingasiza ekunciphiseni ukulimala kwamangqamuzana okubangelwa ama-radicals mahhala.I-Fisetin nayo iboniswe ukunciphisa ukuvuvukala.
Eminyakeni eyi-10 edlule, uMaher kanye nozakwabo baye benza izifundo eziningi ezibonisa ukuthi izakhiwo ze-fisetin ze-antioxidant kanye nezokulwa nokuvuvukala zingasiza ukuvikela amangqamuzana obuchopho emiphumeleni yokuguga.
Olunye ucwaningo olunjalo, olwanyatheliswa ngo-2014, lwathola ukuthi i-fisetin yehlisa ukulahlekelwa inkumbulo kumamodeli wamagundane esifo i-Alzheimer's.Kodwa-ke, lolo cwaningo lugxile emiphumeleni ye-fisetin kumagundane ane-Alzheimer yomndeni, abacwaningi abaqaphela ukuthi ilandisa kuphela kufika kumaphesenti angu-3 azo zonke izimo ze-Alzheimer's.
Ocwaningweni olusha, uMaher nethimba bafuna ukunquma ukuthi i-fisetin ingaba nezinzuzo zesifo i-Alzheimer's esingavamile, okuwuhlobo oluvame kakhulu oluvela ngokukhula.
Ukuze bafinyelele abakutholile, abacwaningi bahlole i-fisetin kumagundane ayenziwe ngofuzo ukuze aguge ngaphambi kwesikhathi, okuholele kumodeli yegundane yesifo i-Alzheimer's sporadic.
Lapho amagundane asekhulile ngaphambi kwesikhathi enezinyanga ezi-3 ubudala, ahlukaniswa ngamaqembu amabili.Iqembu elilodwa lalinikwa umthamo we-fisetin ngokudla kwalo nsuku zonke izinyanga ezingu-7, laze lafinyelela iminyaka eyi-10.Elinye iqembu alizange liyithole inkomponi.
Ithimba lichaza ukuthi ezinyangeni ezingu-10 ubudala, izimo zomzimba nezingqondo zamagundane zazilingana nalezo zamagundane aneminyaka engu-2 ubudala.
Wonke amagundane abengaphansi kokuhlolwa kwengqondo nokuziphatha kulo lonke ucwaningo, futhi abacwaningi baphinde bahlola amagundane ukuze bathole amazinga omaka ahlobene nengcindezi nokuvuvukala.
Abacwaningi bathola ukuthi amagundane anezinyanga ezingu-10 angazange athole i-fisetin abonise ukwanda kwamakaki ahlobene nokucindezeleka nokuvuvukala, futhi enza kabi kakhulu ekuhlolweni kwengqondo kunamagundane alashwa nge-fisetin.
Ebuchosheni bamagundane angalashwa, abacwaningi bathola ukuthi izinhlobo ezimbili zama-neurons ngokuvamile ezilwa nokuvuvukala - i-astrocytes kanye ne-microglia - empeleni zazikhuthaza ukuvuvukala.Nokho, bekungenjalo kumagundane anezinyanga ezingu-10 ubudala aphathwe nge-fisetin.
Ngaphezu kwalokho, abacwaningi bathola ukuthi ukuziphatha kanye nomsebenzi wokuqonda wamagundane alashiwe wawuqhathaniswa nalawo wamagundane anezinyanga ezi-3 ubudala angalashwanga.
Abacwaningi bakholelwa ukuthi abakutholile kubonisa ukuthi i-fisetin ingase iholele esu elisha lokuvimbela i-Alzheimer's, kanye nezinye izifo ze-neurodegenerative ezihlobene neminyaka.
“Ngokusekelwe emsebenzini wethu oqhubekayo, sicabanga ukuthi i-fisetin ingase ibe usizo njengendlela yokuvimbela izifo eziningi ze-neurodeergenerative ezihambisana neminyaka, hhayi nje i-Alzheimer's, futhi singathanda ukukhuthaza ukucwaningwa kwayo ngokucophelela," kusho uMaher.
Kodwa-ke, abacwaningi bayaqaphela ukuthi ukuhlolwa komtholampilo womuntu kuyadingeka ukuze kuqinisekiswe imiphumela yabo.Banethemba lokuthi bazosebenzisana nabanye abaphenyi ukuze bahlangabezane nalesi sidingo.
“Amagundane akubona abantu, yebo.Kodwa kukhona ukufana okwanele esicabanga ukuthi i-fisetin idinga ukubhekisiswa, hhayi nje kuphela ekwelapheni okungase kube khona i-AD [isifo i-Alzheimer] kodwa futhi nokunciphisa eminye yemiphumela yengqondo ehlobene nokuguga, ngokuvamile.”
Isikhathi sokuthumela: Apr-18-2020