Ngo-1913, usosayensi waseSweden uProfessor Kylin wathola ingxenye enamathelayo ye-kelp, fucoidan, e-Uppsala University.Eyaziwa nangokuthi "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", njll., igama lesiNgisi lithi "Fucoidan".Kuyinto ye-polysaccharide encibilika emanzini eyakhiwe i-fucose equkethe amaqembu e-sulfate.Itholakala kakhulu endaweni yolwelwe olunsundu (njengokhula lwasolwandle, ama-akame spores, ne-kelp).Okuqukethwe cishe ku-0.1%, kanti okuqukethwe ku-kelp eyomile cishe ku-1%.Kuyinto eyigugu kakhulu esebenzayo yokhula lwasolwandle.
Okokuqala, ukusebenza kwe-fucoidan
I-Japan njengamanje iyizwe eliphila isikhathi eside kunawo wonke emhlabeni.Ngesikhathi esifanayo, iJapane inezinga eliphansi kakhulu lezifo ezingamahlalakhona.Ngokusho kwezazi zokudla okunomsoco, esinye sezizathu ezibaluleke kakhulu empilweni yabantu baseJapane singase sihlobene nokusetshenziswa njalo kokudla kwasolwandle.I-Fucoidan equkethwe ku-algae ensundu njenge-kelp iyinto esebenzayo enemisebenzi ehlukahlukene yomzimba.Nakuba itholwe nguProfesa Kylin ngo-1913, kwaze kwaba yi-1996 ukuthi i-Fucoidan yanyatheliswa eNgqungqutheleni ye-55th Japanese Cancer Society.Umbiko othi “ungadala i-apoptosis yamangqamuzana omdlavuza” uye wavusa ukukhathazeka okusabalele emphakathini wezemfundo futhi wabangela ukwanda kocwaningo.
Njengamanje, umphakathi wezokwelapha wenza ucwaningo ngemisebenzi ehlukahlukene yezinto eziphilayo ze-fucoidan, futhi ushicilele izinkulungwane zamaphepha kumajenali wezokwelapha wamazwe ngamazwe, eqinisekisa ukuthi i-fucoidan inemisebenzi ehlukahlukene yezinto eziphilayo, njenge-anti-tumor, ukuthuthukisa i-gastrointestinal tract, kanye ne-antioxidant , Thuthukisa ukuzivikela komzimba. , i-antithrombotic, umfutho wegazi ophansi, imiphumela ye-antiviral.
(I) I-Fucoidan ithuthukisa ukusebenza kahle kwamathumbu
I-Helicobacter pylori iyi-helical, microaerobic, i-gram-negative bacilli edinga kakhulu izimo zokukhula.Iwukuphela kwezinhlobo ze-microbial okwamanje eyaziwa ukuthi zisaphila esiswini somuntu.Ukutheleleka kwe-Helicobacter pylori kubangela i-gastritis kanye nomgudu wokugaya ukudla.Izilonda, i-lymphoproliferative gastric lymphomas, njll., zinesimo esibi somdlavuza wesisu.
Izindlela ze-pathogenic ze-H. pylori zihlanganisa: (1) ukunamathela: I-H. pylori ingadlula njengesendlalelo se-mucus futhi ihambisane namaseli e-epithelial esiswini;(2) nciphisa i-asidi yesisu ukuze kuzuze ukuphila: I-H. pylori ikhulula i-urease, futhi i-Urea esiswini isabela ukuze ikhiqize igesi ye-ammonia, eyenza i-asidi yesisu ingabi namandla;(3) ibhubhisa i-mucosa yesisu: I-Helicobacter pylori ikhipha ubuthi be-VacA futhi igugule amangqamuzana angaphezulu e-mucosa yesisu;(4) ikhiqiza i-chloramine enobuthi: igesi ye-ammonia iguguleka ngokuqondile ulwelwesi lwesisu, nomoya-mpilo osebenzayo Ukusabela kuveza i-chloramine enobuthi kakhulu;(5) Ibangela impendulo yokuvuvukala: Ukuze kuvikelwe ngokumelene ne-Helicobacter pylori, inani elikhulu lamangqamuzana amhlophe egazi lihlangana ku-mucosa yesisu ukuze kuvele impendulo yokuvuvukala.
Imiphumela ye-fucoidan ngokumelene ne-Helicobacter pylori ihlanganisa:
1. Ukuvimbela ukwanda kwe-Helicobacter pylori;
Ngo-2014, ithimba labacwaningi be-Yun-Bae Kim eChungbuk National University eSouth Korea lashicilela ucwaningo olubonisa ukuthi i-fucoidan inomphumela omuhle kakhulu wokulwa namagciwane, futhi i-fucoidan ekuhlanganiseni kwe-100µg/mL inganqanda ngokuphelele ukwanda kwe-H. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Vimbela ukunamathela nokuhlasela kwe-Helicobacter pylori;
I-Fucoidan iqukethe amaqembu e-sulfate futhi ingabopha ku-Helicobacter pylori ukuyivimbela ekunamatheleni kumaseli e-epithelial esiswini.Ngesikhathi esifanayo, i-Fucoidan ingavimbela ukukhiqizwa kwe-urease futhi ivikele indawo ene-acidic yesisu.
3. Umphumela we-Antioxidant, unciphisa ukukhiqizwa kobuthi;
I-Fucoidan iyi-antioxidant enhle, engasusa ngokushesha ama-radicals angenayo umoya-mpilo futhi inciphise ukukhiqizwa kwe-chloramine enobuthi obuyingozi.
4. Umphumela wokulwa nokuvuvukala.
I-Fucoidan ingavimbela umsebenzi we-lectin ekhethiwe, umphelelisi kanye ne-heparanase, futhi yehlise impendulo yokuvuvukala.(Helicobacter, 2015, 20, 89–97.)
Ngaphezu kwalokho, abacwaningi bathola ukuthi i-fucoidan inomthelela omkhulu ekuthuthukiseni impilo yamathumbu futhi inomphumela wezindlela ezimbili zokumisa emathunjini: ukuthuthukisa ukuqunjelwa kanye ne-enteritis.
Ngo-2017, ithimba labacwaningi likaSolwazi Ryuji Takeda wase-Kansai University of Welfare Sciences e-Japan lenza ucwaningo.Bakhethe iziguli ezingu-30 ezinokuqunjelwa futhi bazihlukanisa ngamaqembu amabili.Iqembu lokuhlola linikezwe i-1 g ye-fucoidan futhi iqembu lokulawula lanikezwa i-placebo.Ezinyangeni ezimbili ngemva kokuhlolwa, kwatholakala ukuthi inani lezinsuku zokuzikhulula ngeviki eqenjini lokuhlola elithatha i-fucoidan lenyuke lisuka esilinganisweni sezinsuku ezingu-2.7 laya ezinsukwini ezingu-4.6, futhi ivolumu yokukhulula nokuthamba kwanda kakhulu.(Ukudla Okusebenzayo Kwezempilo Nezifo 2017, 7: 735-742.)
Ku-2015, ithimba likaProfesa Nuri Gueven waseNyuvesi yaseTasmania, e-Australia, lathola ukuthi i-fucoidan ingathuthukisa ngokuphumelelayo i-enteritis kumagundane, ngakolunye uhlangothi, ingasiza amagundane ukubuyisela isisindo futhi andise ubulukhuni bokukhipha isisu;ngakolunye uhlangothi, kunganciphisa isisindo sekholoni nobende.Yehlisa ukuvuvukala emzimbeni.(PloS ONE 2015, 10: e0128453.)
B) Umphumela we-Antitumor we-fucoidan
Ucwaningo ngomphumela we-antitumor we-fucoidan okwamanje yilona olukhathazeke kakhulu yimibuthano yezemfundo, futhi miningi imiphumela yocwaningo etholiwe.
1. Ukulawulwa komjikelezo we-tumor cell
Ngo-2015, uSolwazi Lee Sang Hun nabanye eNyuvesi yaseSoonchunhyang eSouth Korea nabanye abacwaningi bathola ukuthi i-fucoidan ivimbela ukuvezwa kwe-cyclin Cyclin kanye ne-cyclin kinase CDK kumaseli e-tumor ngokulawula umjikelezo wokukhula kwamangqamuzana omdlavuza wekoloni lomuntu, okuthinta i-mitosis evamile. ama-tumor cell.Amaseli e-tumor amile esigabeni sangaphambi kwe-mitotic futhi avimbele ukwanda kwamaseli wesimila.(Imibiko Yemithi Yamangqamuzana, 2015, 12, 3446.)
2.Ukungeniswa kwe-tumor cell apoptosis
Ngo-2012, ucwaningo olwanyatheliswa yithimba labacwaningi be-Quan Li eNyuvesi yaseQingdao lwathola ukuthi i-fucoidan ingakwazi ukwenza kusebenze isignali ye-apoptosis yamangqamuzana e-tumor-Bax apoptosis protein, ibangele ukulimala kwe-DNA kumaseli omdlavuza webele, ukuhlangana kwe-chromosome, futhi yenze i-apoptosis ezenzakalelayo yamaseli wesimila., Ivimbele ukukhula kwamaseli wesimila kumagundane.(Plos One, 2012, 7, e43483.)
3.Vimba i-tumor cell metastasis
Ngo-2015, u-Chang-Jer Wu kanye nabanye abacwaningi abavela ku-National Taiwan Ocean University bashicilela ucwaningo olubonisa ukuthi i-fucoidan ingakhuphula isisho se-tissue inhibitory factor (TIMP) kanye ne-down-regulate matrix metalloproteinase (MMP) expression, ngaleyo ndlela ivimbele i-tumor cell metastasis.(Mar. Izidakamizwa 2015, 13, 1882.)
4.Vimba i-angiogenesis yesimila
Ngo-2015, ithimba labacwaningi be-Tz-Chong Chou e-Taiwan Medical Center lathola ukuthi i-fucoidan inganciphisa ukukhiqizwa kwe-vascular endothelial growth factor (VEGF), ivimbele i-neovascularization of tumors, inqamule ukunikezwa kokudla okunomsoco wezimila, ibulale izimila ku- Izinga elikhulu Vimba ukusabalala kanye ne-metastasis yamaseli wesimila.(Mar. Izidakamizwa 2015, 13, 4436.)
5.Vuselela amasosha omzimba
Ngo-2006, uSolwazi Takahisa Nakano wase-Kitasatouniversity University e-Japan wathola ukuthi i-fucoidan ingathuthukisa amasosha omzimba futhi isebenzise amasosha omzimba esiguli ukubulala amangqamuzana omdlavuza.Ngemuva kokuthi i-fucoidan ingene emgudwini wamathumbu, ingabonwa ngamaseli omzimba, ikhiqize amasignali enza amasosha omzimba asebenze, futhi isebenze amaseli e-NK, amaseli e-B, nama-T cell, ngaleyo ndlela akhiqize amasosha omzimba abopha amangqamuzana omdlavuza kanye nama-T cell abulala umdlavuza. amaseli.Ukubulawa okuqondile kwamaseli omdlavuza, okuvimbela ukukhula kwamangqamuzana omdlavuza.(Planta Medica, 2006, 72, 1415.)
Ukukhiqizwa kwe-Fucoidan
Okuqukethwe kwamaqembu e-sulfate esakhiweni samangqamuzana e-fucoidan kuyinkomba ebalulekile enquma umsebenzi wayo wokuphila, futhi iphinde ibe nokuqukethwe okubalulekile kobudlelwane besakhiwo-umsebenzi we-fucoidan.Ngakho-ke, okuqukethwe kweqembu le-sulfate kuyipharamitha ebalulekile yokuhlola ikhwalithi ye-fucoidan kanye nobudlelwano bomsebenzi wesakhiwo.
Muva nje, ilayisense yokukhiqiza ukudla kwe-fucoidan polysaccharide ekugcineni yaqinisekiswa yi-Food and Drug Administration futhi yanikezwa i-Qingdao Mingyue Seaweed Group, okusho ukuthi iMingyue Seaweed Group isineminyaka engaphezu kwengama-50 itshala ulwandle ngokujulile.Thola isitifiketi esisemthethweni.Kubikwa ukuthi iMingyue Seaweed Group yakhe ulayini wokukhiqiza we-fucoidan ophuma minyaka yonke wamathani ayi-10.Ngokuzayo, izonikeza ukudlala okugcwele kumphumela wayo "wemithi nokudla kwe-homology" futhi ikhanyise emkhakheni wokudla osebenzayo wemboni enkulu yezempilo.
I-Mingyue Seaweed Group, njengebhizinisi elivunyelwe ukukhiqizwa kokudla kwe-fucoidan, inesipiliyoni seminyaka eminingi yokukhiqiza.I-fucoidan ekhiqizwe yiyo ingumkhiqizo wokuthuthukisa wezobuchwepheshe we-kelp concentrate / powder yasekuqaleni.Ukusebenzisa ulwelwe olunsundu lwezinga eliphezulu lokudla njengempahla eluhlaza, ukuhlanzwa okuqhubekayo nokwehlukaniswa okusekelwe kubuchwepheshe bokukhishwa kwemvelo, akuthuthukisi nje kuphela ukunambitheka nokunambitheka komkhiqizo, kodwa futhi kukhulisa okuqukethwe kwe-fucoidan polysaccharide (ukuhlanzeka), okungasetshenziswa izinkambu eziningi ezifana nokudla okusebenzayo nokudla okunempilo..Inezinzuzo zokuhlanzeka komkhiqizo ophezulu kanye nokuqukethwe okuphezulu kwamaqembu asebenzayo;ukususwa kwezinsimbi ezinzima, ukuphepha okuphezulu;desalination kanye nokudoba, ukunambitheka kanye nokunambitheka ngcono.
Ukusetshenziswa kwe-Fucoidan
Njengamanje, kunemikhiqizo eminingi ye-fucoidan ethuthukisiwe futhi yasetshenziswa e-Japan, eNingizimu Korea, e-United States nakwamanye amazwe, njenge-fucoidan egxilile eyengeziwe, i-fucoidan ekhipha amaphilisi aluhlaza, kanye nokugcoba ukhula lwasolwandle i-super fucoidan.Ukudla okusebenzayo okufana ne-Seaweed Group's Qingyou Le, Rockweed Treasure, Brown Algae Plant Beverage
Eminyakeni yamuva, “Umbiko Wesimo Sokudla Kwezakhamuzi ZaseShayina Nezifo Ezingamahlalakhona” ubonisa ukuthi ukwakheka kokudla kwezakhamuzi zaseShayina kushintshile, futhi ukwanda kwezifo ezingelapheki kuyanda.Amaphrojekthi amakhulu ezempilo agxile “ekwelapheni izifo” adonse ukunaka okukhulu.Ukusebenzisa i-fucoidan ukuthuthukisa nokukhiqiza ukudla okuningi okusebenzayo kuzohlola ngokugcwele ukubaluleka okuzuzisayo kwe-fucoidan ukunikeza ukuphila nempilo, okubaluleke kakhulu ekuthuthukiseni "imithi enempilo kanye ne-homology yokudla" imboni enkulu yezempilo.
Isixhumanisi somkhiqizo: https://www.trbextract.com/1926.html
Isikhathi sokuthumela: Mar-24-2020