I-Pyrroloquinoline quinone (PQQ), i-antioxidant etholakala ekudleni okufana ne-kiwifruit, itholakale inikeza izinzuzo empilweni yamathambo ocwaningweni lwangaphambilini, okuhlanganisa nezifundo eziphakamisa ukuthi ivimbela i-osteoclastic bone resorption (osteoclastogenesis) futhi ikhuthaza ukwakheka kwamathambo e-osteoblastic (osteoblastogenesis).Kodwa imiphumela emisha yocwaningo lwezilwane ithole, okokuqala ngqa, ukuthi isithako singase futhi sinqande ukukhumuzeka kwamathambo okubangelwa ukuntuleka kwe-testosterone.
Nakuba i-osteoporosis ehlotshaniswa nokunqamuka kokuya esikhathini kuyindaba yezempilo eyaziwa kahle kwabesifazane, i-testosterone-induced osteoporosis emadodeni itholakale empeleni ihlotshaniswa nezinga lokugula okukhulu nokufa ngemva kokuphuka kwe-osteoporotic, nakuba kuvame ukwenzeka kamuva ekuphileni kune-postmenopausal osteoporosis. kwabesifazane.Kodwa-ke, kuze kube manje, abacwaningi bebengakaphenyi ukuthi i-PQQ ingakwazi yini ukuthuthukisa i-osteoporosis exhunywe nokuntuleka kwe-testosterone.
Bebhala ku-American Journal of Translational Research, ababhali bocwaningo babika ukuthi bafunde amaqembu amabili amagundane.Iqembu elilodwa lafakwa i-orchidectomized (ORX; ukuthenwa ngokuhlinzwa), kuyilapho elinye iqembu lahlinzwa mbumbulu.Kwathi emavikini angama-48 alandelayo, amagundane eqenjini le-ORX athola ukudla okuvamile noma ukudla okuvamile kanye no-4 mg PQQ ngekhilogremu ngayinye yokudla.Iqembu lamagundane ahlinza ngomkhovu lithole ukudla okuvamile kuphela.
Ekupheleni kwesikhathi sokwengeza, abacwaningi bathola ukuthi iqembu le-placebo lamagundane e-ORX libe nokuncipha okukhulu kwethambo lamaminerali, ivolumu yamathambo e-trabecular, inombolo ye-osteoblast, kanye ne-collagen deposition uma kuqhathaniswa namagundane angama-sham.Kodwa-ke, iqembu le-PQQ alizange libe nakho ukwehliswa okunjalo.I-Osteoclast surface nayo inyuke kakhulu eqenjini le-ORX placebo uma iqhathaniswa namagundane ehlazo, kodwa yehla kakhulu eqenjini le-PQQ.
"Lolu cwaningo lubonise ukuthi i- [PQQ] ibamba iqhaza ekuvimbeleni i-testosterone-induced osteoporosis ngokuvimbela ukucindezeleka kwe-oxidative kanye nokulimala kwe-DNA, i-cell apoptosis, nokukhuthaza ukwanda kwe-MSC kanye nokuhlukaniswa kwama-osteoblasts nangokuvimbela ukusayina kwe-NF-κB emathanjeni ukunciphisa. i-osteoclastic bone resorption,” kuphetha abacwaningi."Imiphumela yethu evela kulolu cwaningo inikeze ubufakazi bokuhlola bokusetshenziswa komtholampilo kwe- [PQQ] ekwelapheni i-osteoporosis emadodeni asebekhulile."
Wu X et al., "I-Pyrroloquinoline quinone ivimbela i-testosterone-induced osteoporosis ngokuvuselela ukwakheka kwamathambo e-osteoblastic kanye nokuvimbela ukuvuselelwa kwamathambo e-osteoclastic," I-American Journal of Translational Research, vol.9, no.3 (March, 2017): 1230–1242
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Isikhathi sokuthumela: Oct-14-2019