"Ucwaningo lwethu luhlolisise indlela yesenzo se-PEA sisebenzisa iphethini elimisiwe lobuhlungu kumavolontiya anempilo ukuze athole ukuqonda okwengeziwe kwezinqubo ezihilelekile, okubalulekile ekuhlukaniseni ukwelashwa nokuthuthukisa izindlela zokwelapha ezisekelwe emikhiqizweni," abacwaningi babhala.Inyuvesi yaseGraz, exhase lolu cwaningo.
Ocwaningweni olushicilelwe kumagazini okhethekile we- Nutrition, Frontiers in Diet and Chronic Disease: Intuthuko Entsha ku-Fibrosis, Ukuvuvukala Nobuhlungu, i-PEA ibonakala njengenye indlela yemithi yobuhlungu evame ukusetshenziswa njengama-NSAID nama-opioid.
I-PEA yayihlukaniswe nobhontshisi wesoya, izikhupha zamaqanda kanye nofulawa wamantongomane, iyinhlanganisela yensangu eyenzeka ngokwemvelo emzimbeni ngenxa yokulimala nokucindezeleka.
"I-PEA ine-analgesic ebanzi, i-anti-inflammatory, ne-neuroprotective action, okwenza kube i-ejenti ethakazelisayo yokwelapha ubuhlungu," kusho abacwaningi.
"Ukuhlaziywa kwe-meta kwakamuva kwezifundo ezisebenzisa i-PEA yobuhlungu be-neuropathic noma obungapheli kubonise ukusebenza kahle komtholampilo.Kodwa-ke, i-analgesic mechanism eyisisekelo ayizange ifundwe kubantu. "
Ukutadisha indlela yokusebenza ye-PEA, abacwaningi baye bahlonza izindlela ezintathu ezibalulekile, kuhlanganise nokuzwela kwe-peripheral, ukuzwela okuphakathi, nokuguqulwa kobuhlungu.
Kulolu cwaningo olungahleliwe, olulawulwa yi-placebo, oluyimpumputhe kabili, oluwela ngaphezulu, amavolontiya anempilo e-14 athole i-400 mg PEA noma i-placebo kathathu ngosuku amasonto amane.Inkampani yamaDashi i-Innexus Nutraceuticals ihlinzeke nge-PEA, kanti i-placebo yakhiqizwa i-Institutional Pharmacy ye-Medical University of Graz.googletag.cmd.push(umsebenzi () {googletag.display('text-ad1′); });
Ngemuva kwenkathi yesivivinyo sezinsuku ezingu-28, abacwaningi balinganise imiphumela yokulawulwa kobuhlungu obunesimo, umkhawulo wobuhlungu bokucindezela, nokubekezelela ubuhlungu obubandayo ngokusekelwe ezilinganisweni eziyisisekelo.Ukuze kufakwe ukuzwela kwe-peripheral kanye ne-central sensitization yesikhashana, kanye nokutadisha imiphumela ye-analgesic kanye ne-antihyperalgesic, imodeli yobuhlungu evunyelwe "i-repetitive phase heat compress" yasetshenziswa.Ngemva kwenkathi yokuwasha yamaviki angu-8, izilinganiso ezintsha eziyisisekelo zathathwa izinsuku ezingu-28 ngaphambi kokuba ababambiqhaza bashintshelwe kokunye ukungenelela kocwaningo.
Ababambiqhaza eqenjini le-PEA babonise ukuncipha okuphawulekayo ebuhlungu bokushisa obuphindaphindiwe, isivinini esisontekile, kanye nebanga eliqondile le-allodynia (ubuhlungu obubangelwa i-stimuli engenabuhlungu), ukubekezelela ubuhlungu obubandayo okuhlala isikhathi eside, kanye nokwenyuka kokubekezelela ubuhlungu ekuzweleni kobuhlungu bokushisa kanye nokuthinteka.
"Ucwaningo lwamanje lubonisa ukuthi i-PEA inezakhiwo ezithintekayo emtholampilo ngokusebenza ezindleleni ze-peripheral kanye nezimaphakathi kanye nobuhlungu bokulungisa," kuphetha abacwaningi.
Ucwaningo luphakamisa ukuthi ezinye izivivinyo zizohlola ukusebenza kahle kwayo ezigulini ezine-conditioned pain modulation disorder, ukucindezeleka, noma i-fibromyalgia ezwela kakhulu.
"Idatha yethu iphinde isekele ukusebenza kwe-PEA njenge-prophylactic pain reliever," abacwaningi banezela."Le ndlela ingase ihlolwe ngokuqhubekayo ocwaningweni oluzayo, isibonelo ekwelapheni nasekuvimbeleni ubuhlungu obuqhubekayo ngemva kokuhlinzwa."
I-Nutrients 2022, 14 (19), 4084doi: 10.3390 / nu14194084 "Umphumela we-palmitoylethanolamide ekuqineni kobuhlungu, ukuzwela okuphakathi nendawo, kanye nokuguquguquka kobuhlungu kumavolontiya anempilo - isifundo esilawulwa ngokungahleliwe, esilawulwa kabili, i-placebo Kordula Lang-Ilievich et al.
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Isikhathi sokuthumela: Jul-26-2023