Sunan samfur:4-Butylresorcinolfoda
Musammantawa: 98% min
Lambar CAS:18979-61-8
Ma'anar ma'anar Turanci: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN
Tsarin kwayoyin halitta: C10H14O2
Nauyin Kwayoyin: 166.22
Matsayin narkewa: 50 ~ 55 ℃
Matsayin tafasa: 166 ℃/7mmHg (lit.)
Sashi: 0.1-5%
Kunshin: 1kg, 25kg
Menene 4-Butylresorcinol
Sunan sinadari na hukuma shine 4-n-butyl resorcinol, amma gabaɗaya, kowa yana son sauƙaƙa rubuta butyl resorcinol.Na farko da za a ƙara shi a cikin samfuran fata shine POLA na Japan, um~ wanda ya dogara da kwayar cutar da ke cikin wutar gida.
Yana da halin rashin ƙarfi a cikin ruwa da mai narkewa a cikin ethanol.
Mechanism mataki na 4-Butylresorcinol
- Tyrosinase yana taka muhimmiyar rawa wajen samar da melanin saboda yana sarrafa adadin adadin melanin.
- 4-n-butylresorcinol yana da tasiri mai hanawa akan samar da melanin ta hanyar hana ayyukan tyrosinase da B16 baƙar fata mai saurin ƙwayar cuta wanda ke hana haɗin tyrosinase ba tare da haifar da wani cytotoxicity ba.
- A wasu nazarin in vitro, an nuna 4-n-butylresorcinol don hana samar da melanin, da kuma ayyukan tyrosinase da TRP-1.
- Mai hanawa mai ƙarfi na tyrosinase da peroxidase
- Ingantacciyar wakili na fata mai fata da toner na fata na yau da kullun
- Wani tasiri mai tasiri na fata don pigmentation na fata
- Yana da tasiri a kan chlorasma (fatar da aka fallasa fata a cikin rana)
- Yana da tasirin kariya mai ƙarfi akan lalacewar DNA wanda H2O2 ya jawo.
- Tabbatar yana da tasirin anti-glycation
Amfanin 4-Butylresorcinol
Me ya sa ya kamata ka zabi 4-Butylresorcinol
Da farko, muna bukatar mu san dalilin da yasa akwai resorcinol.
Lipofuscin yana daya daga cikin mafi wuyar magancewa a cikin melanin.Gabaɗaya, ana amfani da hydroquinone a kyawun likita.
Hydroquinone wakili ne mai matukar tasiri.Tsarin fararen fata gaba ɗaya yana hana ayyukan tyrosinase kuma yana hana samuwar melanin, kuma tasirin yana da ban mamaki sosai.
Duk da haka, illolinsa daidai suke a bayyane, kuma amfanin yana da illa fiye da amfanin farar fata.
- Yana da oxidizable sosai a cikin iska, kuma dole ne a yi amfani da shi lokacin ƙara shi zuwa kayan shafawa.
- zai iya haifar da ja na fata;
- Idan maida hankali ya wuce 5%, zai haifar da hankali, kuma akwai misalan asibiti na leukoplakia.A halin yanzu, Hukumar Abinci da Magunguna ta Amurka ta kayyade cewa samfuran hydroquinone tare da maida hankali sama da 4% na likitanci ne kuma ba a yarda a tallata su ba.
Masana ilmin sinadarai da magunguna sun canza maganin hydroquinone mai karfi don samun 4-hydroxyphenyl-beta-D-glucopyranoside, wanda shine abin da muke yawan ji game da "arbutin".Bambanci tsakanin hydroquinone shine arbutin yana da ƙananan wutsiya - glycoside fiye da hydroquinone.Abin takaici ne cewa an rage tasirin farin jini sosai.
Shekarun baya-bayan nan, abubuwan da suka fi shahara na manyan kayayyaki sune abubuwan da suka samo asali na benzenediol daban-daban.
Amma kwanciyar hankali na arbutin yana da matukar talauci kuma yana da tasiri kawai da dare.
Amintaccen 4-n-butyl resorcinol ya zama sanannen haske.Ba tare da sakamako masu illa na hydroquinone ba, yana da mafi kyawun maganin warkewa fiye da sauran abubuwan da aka samo na resorcinol.
A cikin gwajin hana ayyukan tyrosinase, bayanansa sun fi kyau fiye da babban ɗan'uwa phenethyl resorcinol, wanda shine sau 100 ~ 6000 na wakili na fari na gargajiya kamar kojic acid arbutin!
Sa'an nan kuma a cikin gwajin gwaji na gaba na melanin B16V, ya kuma nuna fa'idar gama gari na abubuwan da suka samo asali na resorcinol - hana samar da melanin a matakan da ba su haifar da cytotoxicity ba.
Bugu da ƙari, akwai gwaje-gwajen ɗan adam da yawa akan 4-n-butyl resorcinol.A wasu marasa lafiya 32 tare da chlorasma, 0.3% 4-n-butylresorcinol da placebo an yi amfani da su akan kunci biyu.Sau biyu a rana don watanni 3, sakamakon ya kasance raguwa mai mahimmanci a cikin rukunin 4-n-butylresorcinol fiye da rukunin placebo.Akwai mutanen da suke yin gwajin hana pigmentation na wucin gadi bayan kunar rana ta wucin gadi, hmm ~ sakamakon yana da kyau sosai ~
Hana tyrosinase na ɗan adam ta 4-butylresorcinol
4-butylresorcinol, kojic acid, arbutin da hydroquinone sun nuna akan ayyukan L-DOPA oxidase na tyrosinase.Ƙaddara ta hanyoyi daban-daban na masu hanawa don ba da izinin ƙididdige ƙimar IC50.Wannan bayanan shine matsakaicin gwaje-gwaje masu zaman kansu guda uku.
Hana samar da melanin a cikin samfuran fata na MelanoDerm ta 4-butylresorcinol
Kwatanta da ta 4-butylresorcinol, kojic acid, arbutin da hydroquinone a cikin samar da melanin.An nuna ƙayyadaddun abun ciki na melanin na samfuran fata bayan kwanaki 13 na noma a gaban adadin masu hanawa daban-daban.Wannan bayanan shine matsakaicin gwaje-gwaje masu zaman kansu guda biyar.
Shekaru tabo walƙiya ta 4-butylresorcinol
Kwatanta da ta 4-butylresorcinol, kojic acid, arbutin da hydroquinone.Yi maganin tabo sau biyu a rana don makonni 12 tare da mai hanawa daban-daban.Auna ingancin bayan makonni 4, 8 da 12.Bayanai suna wakiltar ma'anar batutuwa 14.*P <0.05: mahimmancin ƙididdiga vs. wuraren da ba a kula da su ba.
Sashi da kuma amfani da 4-Butylresorcinol
Matsakaicin shawarar shine 0.5% -5%.Ko da yake akwai binciken a Koriya wanda ke da wani tasiri akan 0.1% cream, kuma Indiya tana da bincike na 0.3% cream amma kasuwa shine 0.5% -5%.Ya fi kowa, kuma tsarin Jafananci har yanzu ba a san shi ba, amma an yi amfani da POLA.Kuma sakamakon da tallace-tallace suna da ban sha'awa sosai.
Kamar yadda aka ambata a sama, 4-Butylresorcinol za a iya amfani dashi a cikin creams, amma ba shi da narkewa a cikin ruwa.Akwai kuma irin su lotions, creams, da gels.Dukansu POLA da Eucerin suna da samfuran 4-Butylresorcinol.
