Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, da AEA duk sun yi daidai da anandamide kanta.Ta hanyar, (5Z,8Z,11Z,14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide shine sunan sinadarai na anandamide (sunan IUPAC) kuma ana iya amfani dashi kawai a cikin wallafe-wallafen kimiyya.Koyaya, 94421-68-8 shine ID ɗin sinadarai na musamman (Lambar Registry CAS).Tun da AEA shine mafi guntu lokacin anandamide, zamu iya amfani da AEA akai-akai don komawa zuwa anandamide a cikin matani da hotuna masu zuwa.
Sunan samfur:GirmaAnandamide foda
Synonyms: Arachidonoyl Ethanolamide, AEA foda, arachidonoylethanolamide, (5Z,8Z,11Z,14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
Lambar CAS: 94421-68-8
Sashin Shuka Amfani: Leaf
Sinadarin:Apigenin
Assay: AEA mai: 90%
AEA foda: 50%
Launi: Yellowish foda
mai launin rawaya-launin ruwan kasa
Shiryawa: a cikin 25kgs fiber ganguna
Adana: Ajiye akwati a buɗe a wuri mai sanyi, busasshiyar wuri, Nisantar haske mai ƙarfi
Rayuwar Shelf: watanni 24 daga ranar samarwa
A cewar Wikipedia, anandamide wani abu ne mai saurin faruwa na cannabinoid neurotransmitter a cikin kwakwalwa, wanda ke nufin cewa kwakwalwar ɗan adam tana iya samar da anandamide ba tare da cin abinci mai ɗauke da AEA ba.An tabbatar da cewa kwakwalwar nau'in dabbobi masu shayarwa da kuma danyen cacao sun ƙunshi ɗan adadin anandamide.
Hanyoyin abinci na anandamide
Babu yawancin hanyoyin halitta kai tsaye don anandamide, kuma cakulan da truffles suna saman su.Truffle yana da tsada sosai don samun anandamide, kuma cakulan alama shine tushen abin dogaro don dorewa mai yawa daga abinci.
Anandamideda cakulan
Cacao wake, tushen cakulan, shi ma tushen tushen anandamide ne.Akwai fiye da sinadarai 300 a cikin cakulan.Caffeine, theobromine, da phenylethylamine sune sanannun sinadaran da ke haɓaka yanayin mu.Theobromine a zahiri yana taimakawa kwakwalwa don sakin ƙarin anandamide don sa mu ji daɗi.
Me yasa anandamide ke ƙara shahara a cikin 'yan shekarun nan?
Kafin amsa wannan tambayar, muna buƙatar fara ambata cannabis, THC & CBD (Cannabidiol).
Cannabis, wanda kuma aka sani da marijuana, shuka ce mai fure, kuma mutane suna amfani da ita azaman magani na biki ko shan taba don haifar da "high" ko "jifa".
Abubuwan da ke aiki a cikin cannabis wanda ke sa ku girma shine THC, tare da cikakken suna kamar delta 9-Tetrahydrocannabinol.Lokacin da mutane ke shan tabar wiwi, tetrahydrocannabinol a cikin cannabis yana motsa mai karɓar cannabis, yana sa mutane su ji daɗin farin ciki da walwala.
Cannabis haramun ne a ƙasashe da yawa tunda mutane da yawa za su kamu da ita.
Koyaya, Uruguay ita ce ƙasa ta farko da ta halatta tabar wiwi a cikin shekara ta 2013.
A ranar 17 ga Oktoba na 2018, gwamnatin Kanada ta ba da sanarwar cewa cannabis ya zama doka a duk Kanada.
A cikin Amurka, jihohi 10 da Gundumar Columbia sun halatta amfani da wiwi na nishaɗi duk da cewa ya kasance ba bisa ka'ida ba.
Anandamide vs THC
Cannabis shine tushen shuka na THC.
Anandamide shine sigar ɗan adam na THC.
Masanin kimiyya ya gano AEA a cikin 1992 da THC a cikin 1964.
Anandamide yana fitar da sinadarai masu haɓaka yanayi daga kwakwalwa, kuma tsarin halittarsa yayi kama da na tetrahydrocannabinol a cikin cannabis.
Ee, sun yi niyya ga mai karɓar cannabis iri ɗaya, kuma za mu yi magana game da tsarin AEA nan ba da jimawa ba.
Koyaya, ƙarfin THC ya fi ƙarfin AEA.Jin shan AEA ba shi da daɗi fiye da na shan taba tun lokacin anandamide yana haɓaka da sauri a cikin jiki, mai yiwuwa a cikin 30 mins.
Tunda an haramta tabar wiwi a yawancin ƙasashe, kari, abinci, abubuwan sha ko kayan kwalliya masu ɗauke da THC haramun ne.A wannan ma'anar, anandamide shine gaba.
Anandamide vs CBD
Gidan marijuana yana da mahadi 400+, kuma fiye da 60 daban-daban cannabinoids suna ɗaure ga masu karɓa a jikinmu.
CBD shine ɗan gajeren nau'i na cannabidiol kuma yana ɗaya daga cikin 60 cannabinoids.CBD shine phytocannabinoid a cikin cannabis.Fiye da 40% na cirewar cannabis shine CBD.
Masana kimiyya da likitoci sun gano cewa CBD na iya inganta matakin anandamide a cikin synapses na kwakwalwa azaman anandamide reuptake da rushewar hanawa.Fatty acid amide hydrolase, wanda kuma aka sani da FAAH a takaice, wani enzyme ne wanda ke rushe AEA.Wannan shine yadda CBD ke hana FAAH kuma yana inganta AEA a zahiri.
CBD na iya yin fiye da haka.CBD na iya zama da amfani ga duk tsarin Endocannabinoid
Hanyar aikin anandamide
Ta yaya anandamide ke aiki?Yana da rikitarwa lalle.Kuna iya fara buƙatar sanin tsarin endocannabinoid, mai karɓar CB1, da mai karɓar CB2.
Farashin CB1
THC yana da babban kusanci ga mai karɓar CB1, yana haɗa ƙarfi ga mai karɓa.
Bugu da ƙari, anandamide yana haifar da jin daɗin "high" ta hanyar rinjayar mai karɓar CB1, kunna tsarin ladan kwakwalwa da kuma samar da sinadarai masu jin daɗi kamar Dopamine Hormone.
Farashin CB2
Kuna iya samun masu karɓar CB2 a cikin ƙwayoyin rigakafi a cikin jikin ku.Mai karɓa na CB2 yana kula da martanin neuroprotective da yaki da kumburi.Masana kimiyya sun yi imanin cewa mai karɓar CB2 yana da amfani ga jin zafi.
Masu karɓa na CB1 sun fi mayar da hankali ne a cikin kwakwalwa da tsarin CNS, yayin da CB2 masu karɓa suna samuwa a cikin tsarin rigakafi.
Tsarin Endocannabinoid (ECS)
Kafin yin magana game da ayyuka na tsarin endocannabinoid (ECS), yana da mahimmanci don fahimtar abubuwan da ke ciki.ECS ya ƙunshi masu karɓa na cannabinoid, ligands na endogenous (kwayoyin ɗaure) ga waɗancan masu karɓa, da enzymes waɗanda ke haɗawa da lalata haɗin gwiwa.
| ECS na gargajiya | ECS mai tsawo | |
| cannabinoid masu karɓa | CB1, CB2 | PPAR, GPR, TRPV, Flat, FABP |
| endogenous ligands | AEA, 2-AG | OEA,PEA,2-SHEKARA,NADA,VA,EPEA,SEA,OA,DHEA |
| Enzymes masu lalata ligands | FAAH, MAGL | ABHD6, COX-2, ABHD12 |
| Enzymes synthesizing ligands | DAGL, NAT, NAPE-PLD | SHIP1, PTPN22, PLC, GDEI, ABHD4 |
shi da'irar ciki (haske launin toka) wakiltar 'classical' endocannabinoid tsarin.Da'irar waje (mai launin toka mai duhu) ya haɗa da sassa na tsarin endocannabinoid mai tsawo.Kamar yadda kake gani, PEA, SEA, da OEA suna cikin tsarin endocannabinoid.
ECs suna da tushen tsarin juyayi na tsakiya (CNS) kuma sun hada da anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine da N-arachidonylodopamine (NADA).Kuma anandamide shine farkon kuma shine mafi mahimmancin ligand a cikin tsarin endocannabinoid.
Anandamide da 2-AG
Kamar yadda aka ambata a sama, anandamide (AEA) da 2-arachidonoylglycerol (2-AG) sune manyan ligands guda biyu a cikin tsarin ECS.ECS yana taimakawa wajen daidaita ayyuka kamar barci, tsarin rigakafi, da daidaita yanayin zafi.
Masana kimiyya sun gano Anandamide a cikin shekara ta 1992 da 2-AG shekaru 3 bayan haka.AEA da 2-AG suna da tsarin kwayoyin halitta iri ɗaya kuma don haka kaddarorin jiki da sinadarai iri ɗaya.
Anandamide ya fi kai hari ga mai karɓar CB1 a cikin kwakwalwa, yayin da 2-AG ke hari duka CB1 da CB2 masu karɓa (a cikin tsarin rigakafi).
Dukansu Anandamide da 2-AG an haɗa su daga arachidonic acid, Omega-6 fatty acid, tare da hanyoyi daban-daban da kuma hada enzymes.Enzyme mai lalata FAAH (Fatty Acid Amide Hydrolase) don AEA da 2-AG ta MAGL enzyme (Monoacylglycerol Lipase).
Amfanin Anandamide
Shaidar kimiyya ta nuna anandamide na iya zama mai kyau ga rigakafin damuwa, lafiyar hankali, sarrafa ƙwaƙwalwar ajiya, sarrafa abinci, jin zafi, neuroprotection, da ƙari.
Anandamide da damuwa
Mutane suna suna Anandamide "molecule na ni'ima" saboda AEA na iya sa ku ji daɗi.
Haɗin shaida yana nuna cewa tsarin endocannabinoid yana da mahimmancin abubuwan da ke tattare da ƙwayoyin neuronal waɗanda ke cikin tsarin lada na kwakwalwa da martanin tunani ga damuwa.
Pharmacological blockade na enzyme fatty acid amide hydrolase (FAAH), wanda ke da alhakin lalata anandamide na ciki, yana haifar da sakamako mai kama da anxiolytic a cikin berayen ba tare da haifar da nau'ikan martanin halayen halayen halayen kai tsaye na cannabinoid agonists ba.
Wadannan binciken sun nuna cewa anandamide yana ba da gudummawa ga daidaitawar motsin rai da damuwa kuma FAAH na iya zama makasudin sabon nau'in magungunan anxiolytic.
Don ƙarin cikakkun bayanai don tasirin anandamide akan damuwa, da fatan za a karanta wallafe-wallafen da ke ƙasa:
- Cannabinoid anandamide na endogenous yana da tasiri akan motsawa da damuwa waɗanda aka bayyana ta hanyar hana fatty acid amide hydrolase (FAAH).
- Anandamide hydrolysis: sabon manufa don maganin tashin hankali?
- Rage dabi'un damuwa-kamar da aka haifar ta hanyar kwayoyin halitta da hana magunguna na endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) ana yin sulhu ta hanyar masu karɓar CB1.
Anandamide da jin zafi
Hujjojin kimiyya na ome sun nuna cewa hanawa na FAAH (enzyme wanda ke lalata anandamide a cikin kwakwalwa) ya rage yawan amsawar nociceptive a yawancin nau'ikan ciwo.
Masu hana FAAH suna haɓaka matakan anandamide sosai a cikin kwakwalwa kuma sun haifar da CB da farko1Matsakaici mai karɓa na antinociception, yana ba da shawara cewa anandamide na endogenous, lokacin da aka kiyaye shi daga lalacewa, zai iya haifar da antinociception ta hanyar CB.1masu karɓa.
Palmitoylethanolamide (PEA) wani sinadari ne na ƙarshe wanda ke haɓaka ayyukan anandamide.Jikin ɗan adam a zahiri yana ba da PEA don yaƙi da kumburi da zafi.Sama da marasa lafiya 800,000 sun kasance kwayoyin PEA da abubuwan abinci don magance ciwo a duniya.
Don ƙarin koyo game da PEA, da fatan za a ziyarci muShafin PEA.
Anandamide da babban mai gudu
Bari mu fara duban ma'anar abin da girman mai gudu ke da shi: jin daɗin farin ciki tare da raguwar damuwa da ƙarancin jin zafi.Bayan dogon motsa jiki na motsa jiki, za ku fuskanci irin wannan al'amari mai dadi yayin gudu na dogon lokaci.
A cikin shekarun da suka gabata, masu bincike sunyi tunanin cewa endorphin shine kawai abin da ke da alhakin masu gudu tun lokacin da aka samu karuwar matakan β-endorphins a cikin jini.Kamar yadda kuka riga kuka sani, endorphin yana da ikon haɓaka yanayin mu da ƙirƙirar jin daɗin euphoric.
Koyaya, masana kimiyya yanzu sun yi imanin cewa tsarin endocannabinoid (ECS) da anandamide ne ke haifar da girman mai gudu.Anandamide yana iya ketare shingen kwakwalwar jini kuma yana haifar da tasirin tsakiya na opioids na gefe.Amma endorphin ba zai iya ba.
Idan kuna son koyo game da gwajin game da girman mai gudu, karanta wannan adabin:Babban mai gudu ya dogara da masu karɓar cannabinoid a cikin mice
Masana abinci mai gina jiki sun gano cewa anandamide na iya zama mai kula da abinci mai kyau.Anandamide na iya tayar da yunwar ku da sha'awar cin abinci mai yawa.Idan kuna kan hanyar rasa nauyi, yi tunani a hankali kafin shan AEA.
Ƙarin da ke ɗauke da anandamide
Kuna neman kari na anandamide ko kwayoyin anandamide?
Abin takaici, babu ko ɗaya don lokacin.Anandamide sabon sinadari ne wanda babu wani nau'in kari na abinci da ya taɓa gwada shi a cikin dabarun su na yanzu.
Kuna iya samun kamfani mai suna Sun Potion yana siyar da foda anandamide akan Amazon.Duk da haka, wannan ba gaskiya ba ne.Yana da ɗanyen cacao foda, amma ba daidaitaccen tsantsa anandamide ba.Kuma abun ciki mai aiki a cikin foda yana da ƙasa sosai, kuma ƙila ba za ku fuskanci tasirin AEA ba.
Tabbas, zaku iya gano cewa wasu masu siyarwa suna siyar da ƙa'idodin tunani na anandamide ko reagents.Mummunan abu shine kawai suna siyarwa a 5mg, 25mg, kuma kawai don bincike kawai.Babu babban bayanin mai AEA da ke samuwa kwata-kwata.
Labari mai dadi shine cewa masana'antun kari a Amurka da kasashen Turai kamar Jamus, Faransa, Netherland, UK, Spain, Italiya, da sauransu suna yin odar samfuran AEA daga Wuxi Cima Science Co., Ltd, kuma ana kan hanyar samar da kasuwanci mai yawa. .
Anandamide bayani dalla-dalla
Babban man anandamide da foda anandamide duka suna samuwa a Kimiyyar Cima.
Anandamide man: 70%, 90%
Anandamide foda: 50%
