Azelaic acid 98%ta HPLC | Pharmaceutical & Cosmetic Grade
1. Bayanin Samfurin
Azelaic acid(CAS123-99-9) cikakken dicarboxylic acid ne wanda ke faruwa a zahiri tare da tsarin kwayoyin C₉H₁₆O₄ da nauyin kwayoyin 188.22 g/mol. Mu HPLC-tabbatar 98% tsarki sa ya hadu da USP/EP matsayin, inganta don dermatological formulations da masana'antu aikace-aikace.
Maɓalli Maɓalli
- Tsafta: ≥98% (HPLC-ELSD ingantacce, jimlar ƙazanta <0.2%)
- Bayyanar: White crystalline foda
- Matsayin narkewa: 109-111°C
- Tushen tafasa: 286°C a 100 mmHg
- Solubility: 2.14 g / L a cikin ruwa (25 ° C), mai narkewa a cikin maganin ethanol / alkaline
2. Siffar Sinadarai
2.1 Tabbatar da Tsari
- Bayanan martaba na NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H), (br, 2H), 1.2H, 1.2H kowanne, 1.2H, 1.2H. COOH) - HPLC Chromatogram:
Lokacin riƙewa: 20.5 min (babban kolo), ƙarancin ƙazanta <0.1% a 31.5/41.5 min
2.2 Ka'idar Kula da inganci
| Siga | Hanya | Sharuɗɗan karɓa |
|---|---|---|
| Assay | HPLC-ELSD (Agilent 1200) Shafin: Purospher Tauraro RP-C18 Matakin Waya: Methanol/Ruwa/Acetic Acid gradient | 98.0-102.0% |
| Karfe masu nauyi | ICP-MS | ≤10 ppm |
| Ragowar Magani | GC-FID (HP-5MS shafi) Ƙaddamarwa tare da HMDS | Ethanol <0.5% |
3. Aikace-aikacen Magunguna
3.1 Tasirin dermatological
- Cututtukan vulgaris:
Yana rage comedones da 65% a cikin gwaji na makonni 12 (cream 20%) ta:- Maganin rigakafin ƙwayoyin cutaC. kurajen fuska(MIC₅₀ 256 μg/ml)
- Inhibition Tyrosinase (IC₅₀ 3.8 mM) don hyperpigmentation post-mai kumburi.
- Rosacea:
Gel 15% yana nuna raguwar 72% a cikin erythema (vs 43% placebo) ta hanyar:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- MMP-9 kashewa a cikin keratinocytes
3.2 Ka'idojin Tsara
| Form na sashi | Nasiha % | Bayanan dacewa |
|---|---|---|
| Cream/Gel | 15-20% | Guji methylparaben (yana haifar da lalacewar 42%) |
| Liposomal | 5-10% | Yi amfani da phosphate buffer pH7.4 + lecithin waken soya |
4. Aikace-aikace na kwaskwarima
4.1 Farar Haɗin Kai
- Mafi kyawun Haɗuwa:
- 2% AzA + 5% Vitamin C: 31% rage melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x haɓaka haɓakar collagen
4.2 Bayanan kwanciyar hankali
| Yanayi | Ƙimar Ragewa |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Bayyanar UV | 1.2% (tare da kariyar TiO₂) |
5. Amfanin Masana'antu
- Polymer Precursor:
- Nylon-6,9 kira (sakamakon amsawa>85% a 220°C)
- Mai hana lalata na ƙarfe na ƙarfe (0.1M maganin yana rage lalata da 92%)
6. Tsaro & Ka'ida
6.1 Bayanan Bayani na Toxicological
| Siga | Sakamako |
|---|---|
| Babban LD₅₀ (Bera) | > 5000 mg/kg |
| Haushin fata | M (OECD 404) |
| Hadarin ido | Kashi na 2B |
6.2 Yarda da Duniya
- Takaddun shaida:
- US FDA Drug Master File
- EU REACH Rajista
- ISO 9001: 2015 Tsarin inganci
7. Marufi & Adana
| Yawan | Kwantena | Farashin (EXW) |
|---|---|---|
| 25 kg | HDPE drum + Alu jakar | $4,800 |
| 1 kg | Amber gilashin kwalban | $220 |
| 100 g | Jakunkuna mai hatimi sau biyu | $65 |
Ajiye: 2-8°C a busasshiyar wuri (zazzabi na ɗaki ana karɓa idan <25°C/60% RH)
8. FAQs
Tambaya: Zan iya amfani da azelaic acid tare da niacinamide?
A: Ee, bayanan asibiti sun nuna 10% AzA + 4% niacinamide yana haɓaka haƙuri 37% vs AzA kaɗai
Tambaya: Menene rayuwar shiryayye?
A: watanni 36 idan an adana su yadda ya kamata. An bayar da takamaiman COA
9. Magana
- Bayanan Bayani na NMR
- Hanyar HPLC-ELSD
- Karatun kwanciyar hankali
- Ingantaccen asibiti
