Sunan samfur: Tranexamic Acid 98% ta HPLC
Lambar CAS:1197-18-8
Tsarin kwayoyin halitta: C₈H₁₅NO₂
Nauyin Kwayoyin: 157.21 g/mol
Tsafta: ≥98% (HPLC)
Bayyanar: White crystalline foda
Adana: +4°C (na gajeren lokaci), -20°C (tsawon lokaci)
Aikace-aikace: Pharmaceutical, Kayan shafawa, Bincike
1. Bayanin Samfurin
Tranexamic Acid (TXA), analog na lysine na roba, ana amfani dashi ko'ina azaman wakili na antifibrinolytic don rage zubar jini a cikin saitunan tiyata da rauni. An kera wannan samfurin a ƙarƙashin ingantacciyar kulawar inganci, yana tabbatar da tsaftar ≥98% kamar yadda Babban Ayyukan Liquid Chromatography (HPLC) ya tabbatar. Tsarin sinadarai (trans-4- (aminomethyl) cyclohexanecarboxylic acid) da babban kwanciyar hankali ya sa ya dace da aikace-aikace daban-daban, gami da:
- Amfani da Likita: Kula da zubar jini, raunin kwakwalwa (TBI).
- Cosmetics: Skin whitening creams da ake nufi da hyperpigmentation.
- Bincike: Haɓaka hanyoyin bincike da nazarin magunguna.
2. Sinadarai da Abubuwan Jiki
- Sunan IUPAC: 4- (Aminomethyl) cyclohexane-1-carboxylic acid
- MURMUSHI: NC [C@@H] 1CCC @HC(=O)O
- Maɓallin InChI: InChi=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Wurin narkewa: 386°C ( Dec.)
- Solubility: Mai narkewa a cikin ruwa (1N HCl, pH-daidaitacce buffers), methanol, da acetonitrile.
3. Tabbatar da inganci
3.1 Binciken HPLC
Hanyar mu ta HPLC tana tabbatar da ƙayyadaddun ƙididdigewa da ƙazanta bayanan:
- Tushen: XBridge C18 (4.6 mm × 250 mm, 5 μm) ko makamancin haka.
- Matakin Waya: Methanol: buffer acetate (20 mM, pH 4) (75:25 v/v).
- Yawan Yawo: 0.8-0.9 ml/min.
- Ganewa: UV a 220 nm ko 570 nm (bayan da aka samu tare da 1% ninhydrin).
- Dacewar Tsari:
- Madaidaici: ≤2% CV don yanki mafi girma (maimaitawa 6).
- Farfadowa: 98-102% (80%, 100%, 120% matakan spiked).
3.2 Bayanan Najasa
- Najasa A: ≤0.1%.
- Najasa B: ≤0.2%.
- Jimlar ƙazanta: ≤0.2%.
- Halides (kamar Cl⁻): ≤140 ppm.
3.3 Kwanciyar hankali
- pH Stability: Mai jituwa tare da buffers (pH 2-7.4) da mafita na IV na kowa (misali, fructose, sodium chloride).
- Ƙarfafawar thermal: Barga a 37°C na awanni 24 a cikin matrices na halitta.
4. Aikace-aikace
4.1 Amfani da Likita
- Kulawa da Lafiya: Yana rage mace-mace a cikin marasa lafiya na TBI da 20% (gwajin CRASH-3).
- Tiyata: Yana rage asarar jini na ɓarna (orthopedic, tiyata na zuciya).
4.2 Kayan shafawa
- Mechanism: Yana hana plasmin-induced melanogenesis ta hanyar toshe wuraren dauri na lysine.
- Formulations: 3% TXA creams don melasma da hyperpigmentation.
- Tsaro: Yin amfani da waje yana guje wa haɗarin tsarin (misali, thrombosis).
4.3 Bincike & Ci gaba
- Hanyoyin Nazari: Synthesis: Prodrug interconversion Nazarin ƙarƙashin yanayin acidic.
- UPLC-MS/MS: Don nazarin plasma (LOD: 0.1 ppm).
- Fluorimetry: Ƙarfafawa tare da NDA/CN (amfani na minti 5).
5. Marufi & Ajiya
- Marufi na Farko: Jakunkuna na aluminum da aka rufe tare da desiccant.
- Rayuwar Shelf: watanni 24 a -20 ° C.
- Jirgin ruwa: Zazzabi na yanayi (an tabbatar da sa'o'i 72).
6. Tsaro da Biyayya
- Karɓa: Yi amfani da PPE (safofin hannu, tabarau) don guje wa shaƙar numfashi/lamba.
- Matsayin Gudanarwa: Ya dace da USP, EP, da JP pharmacopeias.
- Guba: LD₅₀ (na baka, bera)>5,000 mg/kg; marasa ciwon daji.
7. Magana
- Tabbatar da dacewa da tsarin don HPLC.
- Ƙimar daidaitawa da ƙa'idodin ƙirƙira.
- Kwatanta hanyar UPLC-MS/MS.
- Tasirin farashi a cikin kulawar rauni.
- Kwancen kwaskwarima na kwaskwarima.
Mahimman kalmomi: Tranexamic Acid 98% HPLC, Wakilin Antifibrinolytic, Farin fata, Kulawa da Cutar, UPLC-MS/MS, Gwajin CRASH-3, Maganin Melasma
Bayanin Meta: Tranexamic Acid mai tsafta (≥98% ta HPLC) don amfani da magani, kwaskwarima, da bincike. Ingantattun hanyoyin HPLC, kula da rauni mai tsada mai tsada, da amintattun ƙirar yanayi. Bayanan CAS 1197-18-8.
