Neohesperidin Dihydrochalcone (NHDC)

NHDC a cikin tsaftataccen tsari ana samun shi azaman farin abu ba kamarsa bapowdered sukari.

Wani fili mai kusan sau 1500-1800 mai zaki fiye da sukari a yawan adadin kofa;a kusa da sau 340 mai zaki fiye da nauyin sukari-don-nauyi.Ƙarfinsa ta dabi'a yana shafar abubuwa kamar aikace-aikacen da ake amfani da shi, da kumapHna samfurin.

Kamar sauran dadi sosaiglycosides, kamarglycyrrhizinda wadanda aka samu a cikistevia, NHDC mai ɗanɗano mai ɗanɗano yana da saurin farawa a hankali fiye da sukari kuma yana daɗe a cikin baki na ɗan lokaci.

Sabaninaspartame, NHDC yana da kwanciyar hankali zuwa yanayin zafi mai girma da kuma yanayin acidic ko na asali, don haka ana iya amfani da shi a cikin aikace-aikacen da ke buƙatar rayuwa mai tsawo.NHDC da kanta na iya zama lafiyayyen abinci har zuwa shekaru biyar idan an adana su cikin ingantattun yanayi.

Samfurin sananne ne don samun tasiri mai ƙarfi mai ƙarfi lokacin amfani da shi tare da wasuwucin gadi sweetenerskamaraspartame, saccharin, potassium acesulfame, kumacyclamate, da kuma masu ciwon sukari irin suxylitol.Amfani da NHDC yana haɓaka tasirin waɗannan masu zaki a ƙananan ƙima fiye da yadda ake buƙata;ana buƙatar ƙananan adadin sauran kayan zaki.Wannan yana ba da fa'idar farashi.

Menene Neohesperidin dihydrochalcone?

Neohesperidin dihydrochalcone foda, wanda kuma aka sani da Neohesperidin DC, Neo-DHC da NHDC a takaice, shine ingantaccen kayan zaki wanda neohesperidin ya samar.Ana ɗaukar NHDC a matsayin mai ƙarfi mai ƙarfi, mai zaƙi mara amfani da ɗanɗano mai daɗi;zai iya inganta zaƙi da ingancin girke-girke na abinci daban-daban.

Neohesperidin dihydrochalcone wani fili ne wanda kusan sau 1500-1800 mafi zaki fiye da sukari a adadin ƙofa kuma yana auna kusan sau 340 fiye da sukari.

Neohesperidin dihydrochalcone yawanci ana amfani dashi a cikin masana'antun abinci da ƙari na abinci.

Gano da tushen Neohesperidin dihydrochalcone

An samo Neohesperidin dihydrochalcone a cikin 1960s a matsayin wani ɓangare na Sashen Amurka na aikin bincike na aikin gona don nemo hanyoyin rage ɗaci a cikin ruwan 'ya'yan itace citrus.Neohesperidin wani abu ne mai ɗaci wanda ke wanzuwa a cikin kwasfa da ɓangaren litattafan almara na orange mai ɗaci da sauran 'ya'yan itace citrus;shi ma sinadarin flavonoid ne na 'ya'yan itacen citrus aurantium.Lokacin da aka bi da shi tare da potassium hydroxide ko wani tushe mai ƙarfi, sannan hydrogenated, ya zama Neohesperidin dihydrochalcone (NHDC).

NHDC baya faruwa a yanayi.

Neo-DHC shine hydrogenated daga neohesperidin na halitta - tushen halitta, amma ya sami sauye-sauyen sinadarai, don haka ba samfurin halitta ba ne.

Neohesperidin dihydrochalcone VS sauran kayan zaki

Daban zaki da dandano

Idan aka kwatanta da sucrose, neohesperidin DC yana da kusan sau 1500-1800 fiye da sukari da kuma sau 1,000 fiye da sucrose, yayin da sucralose shine sau 400-800 kuma ace-k ya fi sukari sau 200 zaƙi.

Neohesperidin DC yana ɗanɗano mai tsabta kuma yana da ɗanɗano kaɗan.Kamar sauran high sugar glycosides, irin su glycyrrhizin samu a stevia da kuma wadanda daga licorice tushen, NHDC ta zaki ne jinkirin a farkon farawa fiye da sukari da kuma lingers a baki na dogon lokaci.

Kyakkyawan kwanciyar hankali da aminci mai girma

NHDC yana da kwanciyar hankali a ƙarƙashin yanayin zafi mai zafi, acidic ko yanayin alkaline don haka ana iya amfani dashi a aikace-aikacen da ke buƙatar rayuwa mai tsayi.NHDC na iya kiyaye abinci lafiya har zuwa shekaru biyar a ƙarƙashin ingantattun yanayi

Daban-daban masu karɓa

Tunanin ɗan adam game da zaƙi da ɗanɗano yana daidaitawa ta hanyar T1Rs, dangin farko na GPCRs, TIRs an bayyana su a cikin gustatory na palate mai laushi da harshe, gami da TIR1, T1R2, da TIR3, waɗanda galibi ana samun su ta hanyar dimers.Dimer T1R1-TIR3 shine mai karɓar amino acid, wanda ke bayyanawa kuma yana shiga cikin gane dandano.Dimer T1R2-T1R3 mai karɓa ne mai dadi, wanda ke shiga cikin gane dandano mai dadi.

Masu zaki kamar sucrose, aspartame, saccharin, da cyclamate suna aiki akan tsarin tsarin waje na T1R2.NHDC da cyclamate suna aiki akan sashin transmembrane na T1R3 don samar da zaki.Neohesperidin DC yana hulɗa tare da takamaiman ragowar amino acid a cikin yankin transmembrane na T1R3 don haifar da daɗin kansa kuma a lokaci guda, yana iya haifar da tasirin zaƙi na synergistic na dimer T1R2-T1R3.A matsayin mai zaki, NHDC yana da tasiri mai mahimmanci lokacin da aka haɗa shi tare da sauran kayan zaki tare da ƙananan adadin sinadaran.

Bayan haka, Neohesperidin DC ya bambanta da kayan zaki na gargajiya a cikin ayyukansa na zaƙi, haɓaka ƙamshi, ɓoye ɗaci, da gyaran ɗanɗano.

Fa'idodi da yuwuwar aikace-aikacen neohesperidin dihydrochalcone (NHDC)

Abubuwan Antioxidant

A cikin 'yan shekarun nan, yawancin karatu sun nuna cewa neohesperidin dihydrochalcone yana da gagarumin aiki mai dogara da hankali akan radicals kyauta da nau'in oxygen mai amsawa (ROS).Musamman, NHDC yana da mafi girman tasirin hanawa akan H2O2 da HOCl.(yawan ɓarkewar HOCl da H2O2 shine 93.5% da 73.5% bi da bi)

Menene ƙari, NHDC na iya hana lalata gurɓataccen furotin da ɓarkewar madaidaicin DNA na plasmid, da kuma kare HIT-T15, mutuwar tantanin halitta HUVEC daga harin HOCl.

NHDC yana da ayyukan antioxidant daban-daban akan radicals kyauta daban-daban.Ayyukan antioxidant na NHDC kuma yana nuna cewa zai iya hana tasirin launin ruwan kasa ta hanyar polyphenol oxidase, wanda kuma zai iya hana haɓaka tsarin matrix metalloproteinase (MMP-1) wanda radiation infrared ya haifar, don haka yana kare fata daga jikin ɗan adam. tsufa wanda bai kai ba saboda fallasa hasken infrared.

Aikace-aikace: NHDC na iya zama mai yuwuwar rigakafin launin ruwan kasa da wakili mai fari

Rage sukarin jini da ƙananan Cholesterol

NHDC ingantaccen abu ne, mara guba, ɗanɗano mai ƙarancin kalori wanda ke biyan bukatun mutane don zaƙi kuma don haka yana rage yawan sukari.

Binciken da aka yi kwanan nan ya nuna cewa NHDC na iya hana α-amylase a cikin dabbobi masu shayarwa a nau'i daban-daban sannan kuma a rage yawan shan sukari a jiki, wanda hakan zai rage yawan sukarin jini a cikin jiki, wanda ke da mahimmanci a cikin magunguna, musamman ga masu ciwon sukari.

Aikace-aikace: Ana iya amfani da NHDC azaman mai zaƙi mara-kalori, mai zaki.Idan aka yi amfani da shi yadda ya kamata, yana iya maye gurbin sucrose kuma ya rage cin sucrose na ɗan adam.Ya dace da masu kiba da marasa kiba.

Kare hanta

Zhang Shuo et al.gano cewa NHDC na iya rage matakan ALT, AST a cikin jini da hydroxyproline a cikin kyallen hanta na mice tare da fibrosis hanta da CCI ta haifar da shi, kuma yana rage jinkirin lalacewa da necrosis na sel da fibrosis hanta a cikin digiri daban-daban.Haka kuma, raguwar ALT da AST a cikin jini na iya inganta haɓakar lipid metabolism da aikin hanta, hana samuwar hanta mai kitse da plaque na endothelial a cikin manyan arteries.

Bayan haka, NHDC na iya rage tasirin iskar oxygen da CC1 ta haifar, rage kumburi, da apoptosis tantanin halitta.

Aikace-aikace: NHDC na fatan amfani da shi azaman wakili na hanta.

Hana ciwon ciki

NHDC na iya hana fitowar acid na ciki, don haka ana iya amfani da shi azaman antacid don haɗawa da Aluminum Hydroxide Gel ko sauran abubuwan da ke yin acid na yau da kullun don haɓaka juriya na acid na ƙarshen.

Suhrez et al.An gano cewa NHDC na iya rage yawan ma'anar ciwon ciki wanda ya haifar da damuwa mai sanyi (CRS).Ayyukansa yana kama da na ranitidine, wanda zai iya hana ayyukan histamine kuma ya rage yawan fitar da acid na ciki da pepsin.

Aikace-aikace: NHDC na iya zama sabon ɗanyen abu don maganin ciki.

Daidaita rigakafi

Ana ƙara NHDC don ciyarwa azaman mai zaki, ba wai kawai saboda ɗanɗanonta mai daɗi da haifar da ci na dabba ba, har ma saboda tasirin probiotic da Daly et al ya samu.Lokacin da aka ƙara NHDC zuwa abincin alade, Lactobacillus a cikin ƙofar caecum na piglets ya karu sosai tare da karuwar ƙwayar lactic acid a cikin rami na hanji.Yana iya shafar flora na hanji na symbiotic, daidaita garkuwar jiki, da rage cututtukan hanji.

Aikace-aikacen: Neohesperidin DC za a iya amfani dashi azaman ƙari na abinci, NHDC yana inganta haɓakar abubuwan ciyarwa, ƙara yawan sha'awar dabba, da inganta ƙwayoyin hanji, sannan yana ƙarfafa haɓakarsu.

Neohesperidin DC aminci

NHDC mai zaki ne mara son rai, mara haifuwa.Binciken ƙwaƙƙwara akan guba da aka yi.Metabolism na NHDC a cikin jikin mutum daidai yake da na sauran flavonoid glycosides na halitta.NHDC yana da saurin metabolism, ba mai kuzari ga jikin ɗan adam, kuma babu illa mai guba.

An adana Neo-DHC a cikin Pharmacopoeia na Turai shekaru ashirin da suka gabata kuma Tarayyar Turai ta amince da shi azaman mai zaki, amma ba ta FDA ba.A cikin Amurka, an yarda da neo-DHC don amfani kawai azaman ƙara daɗin dandano.Bayan haka, rajistar NHDC don matsayin GRAS a cikin FDA yana kan hanya.

Neohesperidin dihydrochalcone (NHDC) shawarar kashi da kuma illa.

Don kayan zaki da samfuran kiwo, sashi: 10-35 ppm (mai zaki), 1-5 ppm (mai haɓaka dandano)

Don Masking Cicin Magunguna, adadin: 10-30 ppm (mai zaki), 1-5 ppm (mai haɓaka dandano)

Don abubuwan dandano na abinci, matsakaicin shawarar da aka ba da shawarar: 30-35 mg NHDC / kg cikakken abinci, 5 MG NHDC / L ruwa;3-8 MG NHDC/L ruwa don tsotsa da yaye

Daban-daban dalilai sun ƙayyade kashi.

Duk da haka, idan an sha fiye da haka, kowane sashi na iya haifar da haɗari ga jikin mutum.Nazarin ya nuna cewa neohesperidin dihydrochalcone (NHDC) na iya haifar da tashin zuciya da migraine lokacin da maida hankali ya kasance game da 20 ppm ko fiye.Ana ba da shawarar sanya abin rufe fuska lokacin da ake mu'amala da NHDC mai tsafta

Takaddun Bincike