10-Deacetylbaccatin III (10-DAB)

10-Deacetylbaccatin III (10-DAB) Kiʻi Manaʻo
  • 10-Deacetylbaccatin III (10-DAB)

ʻO ka wehewehe pōkole:

ʻO 10-Deacetylbaccatin III (C29H36O10) he diterpenoid bioactive i unuhi maoli ʻia mai nā nila a me ka ʻili oʻauhauʻano (lāʻau yew). Ma ke ʻano he kumu mua i ka semi-synthesis o paclitaxel, docetaxel, a me nā ʻoihana chemotherapeutic e pili ana i ka ʻauhau, hoʻohana nui ʻia ʻo 10-DAB i ka lāʻau R&D a me ka hana lāʻau oncology.

ʻO 10-Deacetylbaccatin III, ka mea i kapa ʻia ʻo 10-DAB a i ʻole 10-DAB III, kahi hui kūlohelohe kūlohelohe i hoʻokaʻawale ʻia mai nā nila maloʻo a me nā lālā liʻiliʻi o ka lāʻau yew ʻEulopa (Taxus baccata). pacitaxel (taxol); cabazitaxel. Ua ʻike ʻia ʻo 10-10-deacetylbaccatin III e koho koho i ka ulu ʻana o L. DONOVANI intracellular amastigotes i loko o J774 murine macrophages in vitro ma nā nanomolar concentrations me kahi waiwai IC (50) o 70 nM.


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    Huahana Huahana

    Huahana Huahana

    inoa kemika: 10-Deacetylbaccatin III

    Helu CAS:

    32981-86-5
    Nā huaʻōlelo like:

    10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-hoʻokahi, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP Impurity);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-one 12b-acetate, 12-benzoate (USP);
    ʻAno Molekala: C29H36O10
    ʻAno: Paʻa Keʻokeʻo
    Mol. Kaumaha: 544.6
    Waihona: 2-8°C ka pahu hau

    Ke poʻomanaʻo: API i loaʻa i nā mea kanu, CAS32981-86-5| Hōʻoia GMP, Hāʻawi ʻia ʻo COA

    He aha ka 10-Deacetylbaccatin III (10-DAB)?

    ʻO 10-Deacetylbaccatin III (C29H36O10) he diterpenoid bioactive i unuhi maoli ʻia mai nā nila a me ka ʻili oʻauhauʻano (lāʻau yew). Ma ke ʻano he kumu mua i ka semi-synthesis o paclitaxel, docetaxel, a me nā ʻoihana chemotherapeutic e pili ana i ka ʻauhau, hoʻohana nui ʻia ʻo 10-DAB i ka lāʻau R&D a me ka hana lāʻau oncology.

    Nā mea kiko'ī a me nā hiʻohiʻona

    • Maʻemaʻe: ≥98% (HPLC-UV hōʻoia, COA loaʻa)
    • Nani: Keʻokeʻo a keʻokeʻo keʻokeʻo crystalline pauda
    • Solubility: Hiki ke hoʻoheheʻe i ka methanol, ethanol, DMSO; hikiwawe iki i ka wai
    • Ka mālama ʻana: Paʻa ma -20°C i loko o nā pahu paʻa lewa, pale ʻia mai ka mālamalama
    • Puna Mea kanu: ʻohi mau ʻiaTaxus wallichiana(Himalayan yew)

    Nā noi o 10-DAB

    1. ʻO ka hoʻohui ʻana i nā lāʻau lapaʻau anticancer
      • ʻO ka waena koʻikoʻi no ka hana semi-synthetic o paclitaxel (Taxol®) a me docetaxel (Taxotere®).
      • Hoʻohana ʻia i ka R&D no nā derivatives taxane novel e kuhikuhi ana i nā maʻi maʻi lāʻau kūʻē.
    2. Ka noiʻi biochemical
      • Ke aʻo ʻana i nā ʻano hana polymerization tubulin a me ka induction apoptosis.
      • Maʻamau kuhikuhi no ka kemika analytical a me ka hoʻomalu maikaʻi.
    3. Huahana Maoli
      • ʻO ke kaʻina ʻohi hua kiʻekiʻe e pili ana i nā loina kemika ʻōmaʻomaʻo.

    No ke aha ke kumu 10-DAB mai mākou?

    ✅ ʻO ka maikaʻi i hōʻoia ʻia:

    • ʻO ka palapala hōʻoia o ka hōʻiliʻili ʻana (COA) me ka ʻikepili HPLC, MS, NMR.
    • Kūlike me nā alakaʻi alakaʻi USP, EP, a me ICH Q7 GMP.

    ✅ ʻO ke kumu kūʻai mau:

    • ʻOhi ʻia ma ke ʻano kūpono mai nā mahi kanu ʻo Taxus i mahi ʻia (CITES Appendix II compliant).

    ✅ ʻO nā loina o ka honua:

    • ʻO ka hoʻouna ʻana i nā kaulahao anu i ʻAmelika, EU, a me APAC.
    • Hoʻopili ʻia (1g a 1kg, nā hue aniani amber me ka desiccant).

    Kākoʻo ʻenehana & Palapala

    • ʻO ka MSDS manuahi a me ka ʻikepili paʻa ma ke noi.
    • Loaʻa ka synthesis maʻamau a me ke kumu kūʻai nui no nā hoa OEM.
    • Kākoʻo hoʻoponopono i hoʻolaʻa ʻia no nā hoʻouna IND/NDA.

    Palekana & Hoʻokō

    • Helu CAS: 32981-86-5
    • Nā Code Hazard: Hoʻohana me ka PPE (mau mīkina lima, nā maka aniani) - ʻaʻole pilikia no ka hoʻohana ʻoihana.
    • Kūlana Hoʻoponopono: REACH i hoʻopaʻa inoa; Loaʻa ka DMF no nā mea kūʻai aku lāʻau.

    Nā nīnau nīnau no 10-DAB

    Nīnau: Hiki ke hoʻohana pololei ʻia ka 10-DAB i nā haʻawina moʻomeheu cell?
    A: ʻAʻole. Pono ia i ka hoʻololi kemika (e laʻa, hoʻohui i ke kaulahao ʻaoʻao) e lilo i ʻauhau bioactive.

    Q: He aha ka manawa alakaʻi no nā kauoha 500g?
    A: Ka manawa hana maʻamau: 2-3 wiki. Loaʻa ka hoʻouna hōʻike.

    Nīnau: Hāʻawi ʻoe i nā protocol synthesis taxane?
    A: ʻAe! Loaʻa nā pepa keʻokeʻo ʻenehana no nā mea kūʻai aku.

    wehewehe:
    Kumu 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - GMP-certified Taxus extract no ka paclitaxel synthesis. Hoʻokomo ʻia nā kauoha nui, COA/MSDS, a me ke kākoʻo hoʻoponopono.

    1. Hua'ōlelo:
      • Kumua: "10-Deacetylbaccatin III mea hoʻolako", "Maʻemaʻe kiʻekiʻe 10-DAB", "Paclitaxel precursor"
      • Huʻu lōʻihi: "CAS 32981-86-5 kumu kūʻai", "Taxus extract no ka noiʻi maʻi maʻi", "GMP 10-DAB"
    2. Hua'ōlelo:
      • “Taxane intermediate”, “semi-synthetic paclitaxel”, “C29H36O10″, “yew tree compound”
  • Mua:
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