Poʻo inoa: Premium Smoke Tree Extract 98%Fisetinna HPLC | Pākuʻi Antioxidant & Anti-Aging
Hua'ōlelo:Fisetin98%, HPLC Hoʻopaʻa ʻia, Uhi Laʻau Unuhi, Kūlohelohe Kūlohelohe, Pākuʻi Anti-Aging
1. Nānā Huahana
ʻO ka Smoke Tree Extract 98% Fisetin kahi hui kūlohelohe kiʻekiʻe-maʻemaʻe i loaʻa maiCotinus coggygria(Smoke Tree), hoʻohālikelike ʻia i ka 98% Fisetin ma o ka ʻenehana kiʻekiʻe High-Performance Liquid Chromatography (HPLC). ʻO Fisetin (C₁₅H₁₀O₆) he flavonoids i kaulana no kona ikaika antioxidant, anti-inflammatory, a me nā waiwai senolytic, e lilo ia i mea ʻimi ʻia i nā nutraceuticals, cosmetics, and pharmaceutical formulations.
2. Nā mea kiko'ī
- Mea Hana Hana: Fisetin ≥98% (HPLC)
- Helu CAS:528-48-3
- Ke Kumu Molekala: C₁₅H₁₀O₆
- ʻAno: ʻO ka pauka melemele ʻulaʻula
- Solubility: Hiki ke hoʻoheheʻe i ka ethanol, DMSO; hikiwawe iki i ka wai
- Puna Mea kanu:Cotinus coggygrianā lau a me nā ʻōpala
- Nā palapala hōʻoia: GMP, ISO 9001, COA (Certificate of Analysis) i hāʻawi ʻia
3. Ka Hana Hana a me ka Mana Mana
3.1 Hoʻopaʻa ʻia
Hoʻohana mākou i ka ʻokiʻoki CO₂ supercritical e hōʻoia i ka hoʻokaʻawale ʻana o Fisetin a me ka solvent-free o Fisetin, e mālama ana i kona kūpaʻa bioactive.
3.2 Hoʻomaʻemaʻe a me ka hōʻoia HPLC
- Nā Kūlana Chromatographic:
- Kona: ZORBAX C18 (4.6×150 mm, 5 μm)
- ʻĀpana Paʻa: Ka hoʻoheheʻe ʻana me ka 5% acetic acid (Solvent A) a me ka acetonitrile (Solvent B)
- ʻIke: Ka hoʻopaʻa ʻana o UV ma 360 nm, ka manawa paʻa ≈11.6-12.6 min (kūlike me ka maʻamau Fisetin)
- ʻIkepili Nui (MS):
- Manaʻo Ion Pono: m/z 287.05487 (C₁₅H₁₁O₆⁺)
- Manaʻo Ion ʻino: m/z 285.03997 (C₁₅H₉O₆⁻)
- Nā Māhele Māhele: Hoʻohālikelike ʻia me nā kūlana Fisetin ʻoiaʻiʻo e hōʻoia i ke ʻano molekala.
3.3 Hōʻoia Paʻa
Hoʻopili ʻo Fisetin i ka māmā a me ka wela. Hoʻopili ʻia kā mākou huahana i loko o ke aniani amber pale UV me nā desiccants e hōʻoia i ka paʻa i ka wā mālama a me ka lawe ʻana.
4. Nā noi a me nā pono
4.1 Anti-Aging & Senescence
Hana ʻo Fisetin ma ke ʻano he senolytic agent, koho i ka hoʻopau ʻana i nā cell senescent i pili i nā maʻi pili makahiki. Hōʻike nā haʻawina e hoʻonui i ke ola o nā kumu hoʻohālike ma o ka hoʻāla ʻana i nā ala SIRT1.
4.2 Neuroprotection
Kaʻa i ka pale koko-lolo e hōʻemi i ke kaumaha oxidative, hiki ke hoʻēmi i ka holomua o Alzheimer a me Parkinson.
4.3 ʻImi ʻImi ʻAi-Inflammatory & Cancer
Hoʻololi i nā ala NF-κB a me COX-2, ke kāohi nei i nā cytokine pro-inflammatory. Hōʻike ka ʻikepili preclinical i ka hoʻokomo ʻana i ka apoptosis i loko o nā pūnana maʻi maʻi.
4.4 Nā mea hoʻonaninani
Hoʻomaikaʻi nā ʻano kumuhana kumuhana i ka elasticity o ka ʻili a hōʻemi i ka pōʻino i hoʻoiho ʻia e UV ma o ka pale ʻana i nā radical manuahi.
5. Hoʻokō & Palekana
- ʻIkepili Pilikino: LD₅₀ >2000 mg/kg (waha, ʻiole), i helu ʻia ma ke ʻano he mea ʻawaʻawa ʻole.
- Hoʻokō hoʻoponopono: E hui i nā alakaʻi USP, EP, a me FDA no nā mea hoʻohui meaʻai.
- Allergen-Free: Non-GMO, gluten-free, a me ka vegan-friendly.
6. Packaging & Ordering
- Nā Nui Loaʻa: 25 kg/drum (nui), 1 kg (lapana)
- MOQ: 1 kg (nā laʻana); 25 kg no nā kauoha nui.
- Hoʻouna honua: DHL/FedEx me nā koho kaulahao anu no nā ʻāpana wela.
7. NUI
Q: Pehea e hōʻoia ʻia ai ka maʻemaʻe?
A: Loaʻa kēlā me kēia pūʻulu i ka hoʻāʻo ʻelua ma o HPLC a me MS, me COA i hāʻawi ʻia.
Nīnau: Hiki i ka fisetin ke pani i ka quercetin?
A: ʻOiai he mau flavonoids ʻelua, hōʻike ka fisetin i ka bioavailability kiʻekiʻe a me nā hopena senolytic.
Nīnau: Ola ola?
A: 24 mau mahina ke mālama ʻia ma ≤25 ° C i loko o ka sila i hoʻopaʻa ʻia, nā pahu kukui.
8. No ke aha e koho ai iā mākou?
- ʻIke R&D: Hoʻohana i nā ala biosynthesis (e laʻa, P450 monooxygenase optimization) no ka hua kiʻekiʻe.
- Hoʻopilikino: Maʻemaʻe hiki ke hoʻololi (50% ~ 98%) a loaʻa nā lawelawe OEM.
- Hoʻomau: ʻO ka unuhi ʻana i ka wai ethanol me nā loina kemika ʻōmaʻomaʻo.
9. Hoike
- Hui o kahi Novel Biosynthetic Pathway no Fisetin Production (2024) .
- ʻIke HPLC o Flavonoids maSophora japonica(Yang et al., 2017) .
- A. integrifoliaHoʻokaʻawale i ka ʻikepili (Biomedical Science Letters, 2020)
