Azelaic Acid 98%los ntawm HPLC | Pharmaceutical & Cosmetic Qib
1. Cov Khoom Muag Khoom
Azelaic Acid(CAS123-99-9 ib) yog ib txwm tshwm sim saturated dicarboxylic acid nrog molecular mis C₉H₁₆O₄ thiab molecular hnyav 188.22 g / mol. Peb HPLC-tsim pov thawj 98% qib purity raws li USP / EP cov qauv, ua kom zoo rau cov tshuaj dermatological formulations thiab cov ntawv thov kev lag luam.
Ntsiab Specifications
- Purity: ≥98% (HPLC-ELSD validated, tag nrho impurities <0.2%)
- Cov tsos mob: Dawb crystalline hmoov
- Melting Point: 109-111 ° C
- Boiling Point: 286 ° C ntawm 100 mmHg
- Solubility: 2.14 g / L hauv dej (25 ° C), soluble hauv ethanol / alkaline daws
2. Tshuaj Cuam Tshuam
2.1 Kev txheeb xyuas tus qauv
- NMR Profile:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J = 7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26 / 2.32 (t, 2H txhua), 11H, 4.10 (q. COOH) - HPLC Chromatogram:
Lub sij hawm tuav: 20.5 min (lub ncov siab), impurity peaks <0.1% ntawm 31.5 / 41.5 min
2.2 Cov Txheej Txheem Tswjhwm Zoo
| Parameter | Txoj kev | Kev lees txais |
|---|---|---|
| Assay | HPLC-ELSD (Agilent 1200) Kem: Purospher Star RP-C18 Mobile Phase: Methanol/Dej/Acetic Acid gradient | 98.0-102.0% |
| Hnyav Hlau | ICP-MS | ≤10ppm |
| Residual Solvents | GC-FID (HP-5MS kem) Derivation nrog HMDS | Ethanol <0.5% |
3. Kev siv tshuaj
3.1 Dermatological Efficacy
- Pob txuv Vulgaris:
Txo cov comedones los ntawm 65% hauv 12-lub lim tiam sim (20% qab zib) ntawm:- Antimicrobial tawm tsamC. pob txuv(MIC₅₀256 μg / mL)
- Tyrosinase inhibition (IC₅₀ 3.8 mM) rau post-inflammatory hyperpigmentation
- Rosacea:
15% gel qhia 72% txo qis hauv erythema (vs 43% placebo) los ntawm:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- MMP-9 suppression hauv keratinocytes
3.2 Cov Txheej Txheem Kev Cai
| Dosage Form | Pom zoo % | Cov ntawv sau sib raug |
|---|---|---|
| Cream / Gel | 15-20% | Tsis txhob methylparaben (ua rau 42% degradation) |
| Liposomal | 5-10% | Siv phosphate tsis pH7.4 + soybean lecithin |
4. Kev siv tshuaj pleev ib ce
4.1 Whitening Synergy
- Optimal Combinations:
- 2% AzA + 5% Vitamin C: 31% melanin txo vs monotherapy
- 1% AzA + 0.01% Retinol: 2x collagen synthesis boost
4.2 Cov ntaub ntawv ruaj ntseg
| Qhov xwm txheej | Tus nqi degradation |
|---|---|
| 40 ° C / 75% RH (3M) | <0.5% |
| Tiv thaiv UV | 1.2% (nrog TiO₂ tiv thaiv) |
5. Muaj kev siv
- Polymer Precursor:
- Nylon-6,9 synthesis (cov tshuaj tiv thaiv tawm los> 85% ntawm 220 ° C)
- Corrosion inhibitor rau hlau alloys (0.1M tshuaj txo corrosion los ntawm 92%)
6. Kev nyab xeeb & kev tswj hwm
6.1 Toxicological Profile
| Parameter | Kev tshwm sim |
|---|---|
| Mob Qhov ncauj LD₅₀ (Rat) | > 5000 mg/kg |
| Daim tawv nqaij khaus | Mild (OECD 404) |
| Ocular Risk | Qeb 2B |
6.2 Kev Ua Raws Cai Ntiaj Teb
- Cov ntawv pov thawj:
- US FDA Drug Master File
- EU REACH Sau npe
- ISO 9001: 2015 Cov Txheej Txheem Zoo
7. Ntim & Cia
| Ntau | Thawv | Nqe (EXW) |
|---|---|---|
| 25 kg ib | HDPE nruas + Alu hnab | $4,800 |
| 1 kg ib | Amber iav raj mis | $220 |
| 100 g | Ob-sealed hnab | $65 |
Cia: 2-8 ° C nyob rau hauv ib puag ncig qhuav (chav temp tau yog <25 ° C / 60% RH)
8. FAQs
Q: Kuv puas tuaj yeem siv azelaic acid nrog niacinamide?
A: Yog lawm, cov ntaub ntawv kho mob qhia tau hais tias 10% AzA + 4% niacinamide txhim kho tolerability 37% vs AzA ib leeg
Q: Lub neej txee yog dab tsi?
A: 36 lub hlis thaum khaws cia zoo. Batch-specific COA muab
9. Cov ntaub ntawv
- NMR cov ntaub ntawv tus cwj pwm
- Cov txheej txheem HPLC-ELSD
- Kev tshawb fawb txog kev ruaj ntseg
- Clinical kev ua tau zoo
