Khoom npe: Tranexamic Acid 98% los ntawm HPLC
CAS Nr:.1197-18-8 ib
Molecular Formula: C₈H₁₅NO₂
Molecular Luj: 157.21 g / mol
Purity: ≥98% (HPLC)
Cov tsos mob: Dawb crystalline hmoov
Cia: +4 ° C (lub sijhawm luv), -20 ° C (ntev ntev)
Daim ntawv thov: Pharmaceutical, Tshuaj pleev ib ce, tshawb fawb
1. Cov Khoom Muag Khoom
Tranexamic Acid (TXA), hluavtaws lysine analog, yog dav siv los ua tus neeg sawv cev antifibrinolytic los txo cov ntshav hauv kev phais thiab kev raug mob. Cov khoom no yog tsim los ntawm kev tswj xyuas nruj, ua kom muaj purity ntawm ≥98% raws li kev txheeb xyuas los ntawm High-Performance Liquid Chromatography (HPLC). Nws cov qauv tshuaj (trans-4-(aminomethyl)cyclohexanecarboxylic acid) thiab kev ruaj ntseg siab ua rau nws haum rau ntau hom kev siv, suav nrog:
- Kev Siv Kho Mob: Kev tswj ntshav siab, kev kho mob hlwb raug mob (TBI).
- Tshuaj pleev ib ce: daim tawv nqaij whitening cream tsom hyperpigmentation.
- Kev Tshawb Fawb: Kev Tshawb Fawb Txog Kev Txhim Kho thiab kev tshawb fawb pharmacokinetic.
2. Chemical thiab Physical Properties
- IUPAC Lub Npe: 4-(Aminomethyl)cyclohexane-1-carboxylic acid
- SMILES: NC [C@@H]1CCC@HC(=O)O
- InChI Key: InChI = 1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Melting Point: 386 ° C (Lub Kaum Ob Hlis)
- Solubility: Soluble nyob rau hauv dej (1N HCl, pH-adjusted buffers), methanol, thiab acetonitrile.
3. Kev ruaj ntseg zoo
3.1 HPLC Kev Ntsuam Xyuas
Peb txoj kev HPLC ua kom muaj qhov tseeb thiab qhov tsis zoo ntawm qhov profile:
- Kem: XBridge C18 (4.6 mm × 250 mm, 5 μm) los yog sib npaug.
- Mobile Phase: Methanol: acetate buffer (20 mM, pH 4) (75:25 v/v).
- Tus nqi ntws: 0.8-0.9 mL / min.
- Kev kuaj pom: UV ntawm 220 nm lossis 570 nm (post-derivatization nrog 1% ninhydrin).
- Qhov System Suitability:
- Precision: ≤2% CV rau thaj tsam ncov (6 replicates).
- Rov qab: 98-102% (80%, 100%, 120% spiked qib).
3.2 Impurity Profile
- impurity A: ≤0.1%.
- impurity B: ≤0.2%.
- Tag nrho cov impurities: ≤0.2%.
- Halides (raws li Cl⁻): ≤140 ppm.
3.3 Kev ruaj ntseg
- pH Stability: Tau tshaj buffers (pH 2–7.4) thiab IV kev daws teeb meem (xws li fructose, sodium chloride).
- Thermal Stability: ruaj khov ntawm 37 ° C rau 24 teev nyob rau hauv biological matrices.
4. Cov ntawv thov
4.1 Kev Siv Kho Mob
- Kev Kho Mob: Txo kev tuag hauv cov neeg mob TBI los ntawm 20% (CRASH-3 sim).
- Kev phais: txo qis cov ntshav perioperative (orthopedic, phais plawv).
4.2 Tshuaj pleev ib ce
- Mechanism: Inhibits plasmin-induced melanogenesis los ntawm thaiv qhov chaw lysine-binding.
- Formulations: 3% TXA creams for melasma and hyperpigmentation.
- Kev Nyab Xeeb: Kev siv tshuaj pleev kom tsis txhob muaj kev pheej hmoo ntawm lub cev (xws li, thrombosis).
4.3 Kev Tshawb Fawb & Kev Txhim Kho
- Txoj kev tsom xam: Synthesis: Prodrug interconversion kev tshawb fawb nyob rau hauv acidic tej yam kev mob.
- UPLC-MS/MS: Rau ntshav tsom xam (LOD: 0.1 ppm).
- Fluorimetry: Derivatization nrog NDA / CN (5-feeb tshuaj tiv thaiv).
5. Ntim & Cia
- Kev ntim khoom tseem ceeb: kaw lub hnab aluminium nrog desiccant.
- Txee Lub neej: 24 lub hlis ntawm -20 ° C.
- Shipping: ambient kub (validated rau 72 teev).
6. Kev nyab xeeb thiab kev ua raws cai
- Kev tuav: Siv PPE ( hnab looj tes, tsom iav) kom tsis txhob nqus pa / tiv tauj.
- Regulatory Status: Ua raws li USP, EP, thiab JP pharmacopeias.
- Toxicity: LD₅₀ (qhov ncauj, nas)> 5,000 mg/kg; non-carcinogenic.
7. Cov ntaub ntawv
- Kev tsim nyog tau txais kev pom zoo rau HPLC.
- Calibration nkhaus thiab derivatization raws tu qauv.
- UPLC-MS/MS txoj kev sib piv.
- Tus nqi-zoo hauv kev kho mob.
- Cosmetic formulation stability.
Keywords: Tranexamic Acid 98% HPLC, Antifibrinolytic Agent, Daim tawv nqaij ntxuav hniav dawb, Kev kho mob, UPLC-MS/MS, CRASH-3 sim, Melasma kho
Meta Description: High-purity Tranexamic Acid (≥98% los ntawm HPLC) rau kev kho mob, tshuaj pleev ib ce, thiab kev tshawb fawb siv. Cov txheej txheem HPLC raug lees paub, kev kho mob raug nqi raug nqi, thiab cov qauv tshuaj pleev xim zoo. CAS 1197-18-8 Nr.
