Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, thiab AEA yog txhua yam sib npaug rau anandamide nws tus kheej.Los ntawm txoj kev, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide yog anandamide lub npe tshuaj (IUPAC lub npe) thiab tsuas yog siv rau hauv cov ntaub ntawv tshawb fawb.Txawm li cas los xij, 94421-68-8 yog nws cov tshuaj ID (CAS Registry Number).Txij li thaum AEA yog lub sij hawm luv tshaj rau anandamide, peb yuav siv AEA nquag xa mus rau anandamide hauv cov ntawv thiab cov duab hauv qab no.
Khoom npe:TejAnandamide hmoov
Synonyms: Arachidonoyl Ethanolamide, AEA hmoov, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
CAS Nr .: 94421-68-8
Cog Tshooj Siv: Nplooj
Cov khoom xyaw: Apigenin
Assay: AEA roj: 90%
AEA hmoov: 50%
Xim: daj hmoov
yellowish-xim av roj
Ntim: hauv 25kgs fiber ntau nruas
Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog
Lub neej txee: 24 lub hlis txij li hnub tsim khoom
Raws li Wikipedia, anandamide yog ib qho endogenous tshwm sim cannabinoid neurotransmitter hauv lub hlwb, uas txhais tau hais tias tib neeg lub hlwb muaj peev xwm tsim anandamide yam tsis tau noj cov zaub mov uas muaj AEA.Lub hlwb ntawm cov tsiaj txhu thiab cov cacao nyoos tau lees paub tias muaj qee qhov ntawm anandamide.
Cov khoom noj ntawm anandamide
Tsis muaj ntau qhov chaw ncaj qha rau anandamide, thiab chocolate thiab truffles nyob rau saum lawv.Truffle yog kim heev kom tau txais rau anandamide, thiab chocolate zoo li yog qhov kev ntseeg siab tshaj plaws rau kev noj qab haus huv ntau ntawm cov khoom noj.
Anandamidethiab chocolates
Cacao taum, qhov chaw ntawm chocolates, kuj yog ib qho chaw nplua nuj ntawm anandamide.Muaj ntau dua 300 cov tshuaj lom neeg hauv chocolate.Caffeine, theobromine, thiab phenylethylamine yog cov khoom xyaw paub uas txhawb peb lub siab.Theobromine yeej pab txhawb lub hlwb kom tso tawm ntau anandamide ua rau peb zoo siab.
Vim li cas anandamide thiaj li nrov nyob rau xyoo tas los no?
Ua ntej teb cov lus nug no, peb yuav tsum hais txog cannabis, THC & CBD (Cannabidiol) ua ntej.
Cannabis, tseem hu ua yeeb tshuaj xas, yog ib tsob ntoo paj, thiab tib neeg siv nws los ua cov tshuaj lom neeg lossis haus luam yeeb los tsim qhov "siab" lossis "pob zeb".
Cov khoom xyaw nquag hauv cannabis uas ua rau koj siab yog THC, nrog lub npe tag nrho li delta 9-Tetrahydrocannabinol.Thaum tib neeg haus luam yeeb tshuaj maj, tetrahydrocannabinol hauv cannabis txhawb nqa cov neeg txais cannabis, ua rau tib neeg muaj kev zoo siab thiab kev noj qab haus huv ntawm lub hlwb.
Cannabis yog qhov txhaum cai hauv ntau lub tebchaws vim tias ntau tus neeg yuav quav nws.
Txawm li cas los xij, Uruguay yog thawj lub tebchaws ua kom muaj kev cai lij choj cannabis hauv xyoo 2013.
Thaum Lub Kaum Hli 17 ntawm 2018, tsoomfwv Canadian tshaj tawm tias cannabis tau dhau los ua kev cai lij choj thoob tebchaws Canada.
Hauv Tebchaws Meskas, 10 lub xeev thiab Koog Tsev Kawm Ntawv ntawm Columbia tau tso cai rau kev siv ua si ntawm cannabis txawm tias nws tseem tsis raug cai hauv tsoomfwv.
Anandamide vs THC
Cannabis yog cov nroj tsuag ntawm THC.
Anandamide yog tib neeg version ntawm THC.
Tus kws tshawb fawb pom AEA hauv xyoo 1992 thiab THC hauv xyoo 1964.
Anandamide tso tawm cov tshuaj lom neeg lub siab los ntawm lub hlwb, thiab nws cov txheej txheem lom neeg zoo ib yam li tetrahydrocannabinol hauv cannabis.
Yog lawm, lawv tsom rau tib tus neeg txais cannabis, thiab peb yuav tham txog lub tshuab ntawm AEA sai sai.
Txawm li cas los xij, lub zog ntawm THC muaj zog ntau dua li AEA.Qhov kev xav ntawm kev noj AEA tsis zoo siab dua li kev haus luam yeeb cannabis txij li anandamide metabolizes sai hauv lub cev, tej zaum hauv 30 mins.
Txij li thaum cannabis raug txwv nyob rau hauv ntau lub tebchaws, cov tshuaj, khoom noj, dej haus lossis tshuaj pleev ib ce uas muaj THC yog txhaum cai.Hauv qhov kev nkag siab no, anandamide yog lub neej yav tom ntej.
Anandamide vs CBD
Cov nroj tsuag tshuaj maj muaj 400+ tebchaw, thiab ntau dua 60 qhov sib txawv cannabinoids khi rau receptors hauv peb lub cev.
CBD yog daim ntawv luv luv ntawm cannabidiol thiab yog ib qho ntawm 60 cannabinoids.CBD yog phytocannabinoid hauv cannabis.Ntau tshaj 40% ntawm cannabis extract yog CBD.
Cov kws tshawb fawb thiab kws kho mob pom tias CBD tuaj yeem txhim kho anandamide qib hauv lub hlwb synapses raws li anandamide reuptake thiab rhuav tshem inhibitor.Fatty acid amide hydrolase, tseem hu ua FAAH luv luv, yog ib qho enzyme uas zom AEA.Qhov ntawd yog li cas CBD inhibits FAAH thiab txhim kho AEA ib txwm muaj.
CBD tuaj yeem ua tau ntau dua li qhov ntawd.CBD tuaj yeem muaj txiaj ntsig zoo rau tag nrho Endocannabinoid System
Mechanism ntawm kev txiav txim ntawm anandamide
Anandamide ua haujlwm li cas?Nws nyuaj tiag tiag.Tej zaum koj yuav tsum xub paub txog qhov endocannabinoid system, CB1 receptor, thiab CB2 receptor.
CB 1
THC muaj affinity siab rau CB1 receptor, sib txuas lus zoo rau cov receptor.
Tsis tas li ntawd, anandamide cuam tshuam rau "siab" kev xav los ntawm kev cuam tshuam rau CB1 receptor, ua kom lub paj hlwb lub nqi zog thiab tsim cov tshuaj lom neeg xws li dopamine Hormone.
CB 2
Koj tuaj yeem pom CB2 receptors hauv lub cev tiv thaiv kab mob thoob plaws hauv koj lub cev.CB2 receptor yog tus saib xyuas cov lus teb neuroprotective thiab tawm tsam qhov mob.Cov kws tshawb fawb ntseeg tias CB2 receptor muaj txiaj ntsig zoo rau kev kho mob.
CB1 receptors yog concentrated feem ntau hauv lub hlwb thiab CNS system, thaum CB2 receptors feem ntau pom nyob rau hauv lub cev tiv thaiv kab mob.
Endocannabinoid System (ECS)
Ua ntej sib tham txog cov haujlwm ntawm endocannabinoid system (ECS), nws yog ib qho tseem ceeb kom nkag siab txog nws cov khoom.Lub ECS muaj xws li cannabinoid receptors, endogenous ligands (binding molecules) rau cov receptors, thiab enzymes uas synthesize thiab degrade lub ligands.
| classical ECS | Extended ECS | |
| cannabinoid receptors | CB1, CB 2 | PPAR, GPR, TRPV, FLAT, FABP |
| endogenous ligands | AW, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| Enzymes degrading ligands | FAAH, MAGL | ABHD6,COX-2,ABHD12 |
| Enzymes synthesizing ligands | DAGL, NAT, NAPE-PLD | SHIP1, PTPN22, PLC, GDEI, ABHD4 |
nws lub voj voog sab hauv (lub teeb grey) sawv cev rau 'classical' endocannabinoid system.Lub voj voog sab nrauv (tsaus grey) suav nrog cov khoom txuas ntxiv ntawm endocannabinoid system.Raws li koj tuaj yeem pom, PEA, SEA, thiab OEA kuj suav nrog cov kab ke endocannabinoid.
Cov ECs muaj lub hauv paus paj hlwb (CNS) keeb kwm thiab suav nrog anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine thiab N-arachidonylodopamine (NADA).Thiab anandamide yog thawj zaug thiab tseem ceeb tshaj plaws ligand hauv endocannabinoid system.
Anandamide thiab 2-AG
Raws li tau hais los saum no, anandamide (AEA) thiab 2-arachidonoylglycerol (2-AG) yog ob lub ligands hauv ECS system.ECS pab tswj kev ua haujlwm xws li pw tsaug zog, tiv thaiv kab mob, thiab kho qhov mob.
Cov kws tshawb fawb pom Anandamide xyoo 1992 thiab 2-AG 3 xyoo tom qab.AEA thiab 2-AG muaj cov qauv molecular zoo sib xws thiab yog li tib lub cev thiab tshuaj lom neeg.
Anandamide feem ntau yog tsom rau cov receptor CB1 hauv lub hlwb, thaum 2-AG tsom rau CB1 thiab CB2 receptors (hauv lub cev tiv thaiv kab mob).
Anandamide thiab 2-AG yog synthesized los ntawm arachidonic acid, ib qho Omega-6 fatty acid, nrog rau txoj kev sib txawv thiab synthesizing enzymes.Degrading enzyme FAAH (Fatty Acid Amide Hydrolase) rau AEA thiab 2-AG los ntawm MAGL enzyme (Monoacylglycerol Lipase).
Cov txiaj ntsig Anandamide
Cov pov thawj tshawb fawb qhia tias anandamide tuaj yeem ua tau zoo rau kev tiv thaiv kev ntxhov siab, kev noj qab haus huv ntawm lub hlwb, kev nco, kev noj qab haus huv, kev kho mob, kev tiv thaiv kab mob, thiab lwm yam.
Anandamide thiab kev ntxhov siab
Cov neeg hu ua Anandamide "bliss molecule" vim AEA muaj peev xwm ua rau koj zoo siab.
Converging pov thawj qhia tias endocannabinoid system yog ib qho tseem ceeb ntawm cov neuronal substrates koom nrog hauv lub hlwb nqi zog cov txheej txheem thiab lub siab xav teb rau kev ntxhov siab.
Pharmacological blockade ntawm enzyme fatty acid amide hydrolase (FAAH), uas yog lub luag haujlwm rau intracellular anandamide degradation, ua rau anxiolytic zoo li cov teebmeem hauv nas yam tsis ua rau lub dav spectrum ntawm kev coj tus cwj pwm cov lus teb zoo ib yam ntawm direct-acting cannabinoid agonists.
Cov kev tshawb pom no qhia tias anandamide pab txhawb rau kev tswj hwm ntawm kev xav thiab kev ntxhov siab thiab FAAH tej zaum yuav yog lub hom phiaj rau cov chav kawm tshiab ntawm cov tshuaj anxiolytic.
Yog xav paub ntxiv txog cov teebmeem anandamide ntawm kev ntxhov siab, thov nyeem cov ntawv hauv qab no:
- Cov endogenous cannabinoid anandamide muaj kev cuam tshuam rau kev txhawb siab thiab kev ntxhov siab uas tau tshwm sim los ntawm fatty acid amide hydrolase (FAAH) inhibition.
- Anandamide hydrolysis: lub hom phiaj tshiab rau tshuaj tiv thaiv kev ntxhov siab?
- Txo kev ntxhov siab zoo li tus cwj pwm tshwm sim los ntawm kev tshuaj ntsuam genetic thiab pharmacological inhibition ntawm endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) yog kho los ntawm CB1 receptors.
Anandamide thiab mob nyem
ome scientific pov thawj qhia tau hais tias inhibition ntawm FAAH (lub enzyme uas degrades anandamide nyob rau hauv lub hlwb) zoo heev txo cov nociceptive teb nyob rau hauv ntau yam mob qauv.
FAAH inhibitors tau txhim kho qib anandamide hauv lub hlwb thiab feem ntau ua rau CB1receptor-mediated antinociception, qhia tias endogenous anandamide, thaum tiv thaiv los ntawm degradation, tuaj yeem tsim antinociception los ntawm CB.1cov receptors.
Palmitoylethanolamide (PEA) yog cov khoom siv endogenous uas txhawb nqa kev ua haujlwm anandamide.Tib neeg lub cev ib txwm yields PEA los tawm tsam qhov mob thiab mob.Ntau tshaj 800,000 tus neeg mob tau ua tshuaj PEA thiab cov khoom noj khoom haus los kho qhov mob hauv ntiaj teb.
Yog xav paub ntxiv txog PEA, thov mus saib pebPIB page.
Anandamide thiab khiav siab
Cia peb saib thawj lub ntsiab lus ntawm tus neeg khiav lub siab yog dab tsi: qhov kev xav ntawm euphoria nrog txo kev ntxhov siab thiab tsis muaj peev xwm hnov mob.Tom qab kev tawm dag zog aerobic ntev, koj yuav ntsib qhov tshwm sim zoo li no thaum lub sijhawm ua haujlwm ntev.
Nyob rau hauv xyoo tas los no, cov kws tshawb fawb tau xav tias endorphin tsuas yog lub luag haujlwm rau cov neeg khiav dej num siab vim tias qhov nce qib ntawm β-endorphins tau yooj yim pom hauv cov ntshav.Raws li koj twb paub lawm, endorphin muaj peev xwm txhim kho peb lub siab xav thiab tsim kom muaj kev zoo siab.
Txawm li cas los xij, tam sim no cov kws tshawb fawb ntseeg tias nws yog endocannabinoid system (ECS) thiab anandamide uas ua rau tus neeg khiav dej num siab.Anandamide muaj peev xwm hla cov ntshav-hlwb teeb meem thiab ua rau lub hauv paus los ntawm peripheral opioids.Tab sis endorphin ua tsis tau.
Yog tias koj xav kawm txog qhov kev sim hais txog kev khiav lub siab, nyeem cov ntawv no:Tus khiav lub siab nyob ntawm cannabinoid receptors hauv nas
Nutritionists pom tias anandamide kuj yuav yog tus tswj kev noj qab haus huv zoo.Anandamide tuaj yeem ua rau koj tshaib plab thiab xav noj ntau dua.Yog tias koj nyob ntawm txoj kev kom poob phaus, ua tib zoo xav ua ntej noj AEA.
Cov tshuaj ntxiv uas muaj anandamide
Puas yog koj tab tom nrhiav tshuaj anandamide lossis tshuaj anandamide?
Hmoov tsis, tsis muaj rau lub sijhawm.Anandamide yog cov khoom xyaw tshiab uas tsis muaj cov khoom noj khoom haus ntxiv tau sim nws hauv lawv cov qauv tam sim no.
Koj tuaj yeem pom lub tuam txhab npe hu ua Sun Potion yog muag cov hmoov anandamide ntawm Amazon.Txawm li cas los xij, qhov ntawd tsis yog qhov tseeb.Nws tsuas yog cov hmoov cacao nyoos, tab sis tsis yog tus qauv anandamide extract.Thiab cov ntsiab lus nquag hauv daim ntawv hmoov yog tsawg heev, thiab koj yuav tsis paub txog AEA qhov ua tau zoo.
Tau kawg, koj tuaj yeem pom tias qee tus neeg muag khoom muag cov qauv siv anandamide lossis cov tshuaj reagents.Qhov tsis zoo yog tias lawv tsuas muag ntawm 5mg, 25mg, thiab tsuas yog rau kev tshawb fawb xwb.Tsis muaj cov ntaub ntawv AEA roj ntau muaj nyob rau txhua qhov.
Cov xov xwm zoo yog tias cov tuam txhab ntxiv hauv Tebchaws Meskas thiab Tebchaws Europe xws li Lub Tebchaws Yelemees, Fabkis, Netherland, UK, Spain, Ltalis, thiab lwm yam tau xaj AEA cov qauv los ntawm Wuxi Cima Science Co., Ltd, thiab cov khoom lag luam ntau yog nyob rau hauv txoj kev. .
Anandamide specifications
Bulk anandamide roj thiab anandamide hmoov yog ob qho tib si muaj nyob rau ntawm Cima Science.
Anandamide roj: 70%, 90%
Anandamide hmoov: 50%
