Khoom npe:Stearoyl Vanillylamide yog ib qho tshuaj tiv thaiv kab mob(SVA)
Lwm Lub Npe: C18-VA, N-Vanillyloctadecanamide, Capsaicin AnalogCAS Ntus lej:58493-50-8
Botanical Source: Piper Longum Linn
Kev Ntsuas: 98%
Qauv Dawb: Muaj
Cov tsos mob: dawb mus rau cov hmoov dawb
Cov txiaj ntsig: Anti-cancer, anti-aging, senolytic
Lub neej txee: 2 xyoos
Stearoyl vanillylamide yog ib qho ntawm cov npe nrov tshaj plaws capsaicin analogs thiab yog ib txwm tshwm sim capsaicin analog pom hauv cov kua txob liab.Capsaicin yog qhov ua rau muaj cua sov / kub hnyiab los ntawm kua txob.Tsis zoo li lwm hom capsaicin hauv tib pawg, Stearoyl vanillylamide yog qhov tshwj xeeb hauv qhov uas nws tsis yog-steroidal, txhais tau tias nws tsis tsim cov "ntses" lossis ua rau khaus ntawm capsaicin.
Feem ntau, zoo li lwm yam capsaicin analogs, cov tshuaj no ua los ntawm kev txhim kho kev tso tawm ntawm epinephrine thiab norepinephrine.Cov tshuaj hormones no yuav tsum tau ua kom muaj ntau yam kev mob siab rau lub cev xws li cov metabolism.Yog li ntawd, stearoyl vanillylamide thaum kawg txhawb kev hlawv cov rog xim av hauv cov ntaub so ntswg adipose lossis cov ntaub so ntswg subcutaneous.
Dab tsi yog cov txiaj ntsig los siv Stearoyl Vanillylamide?Kev suav nrog stearic acid amide muaj ntau qhov zoo hauv kev npaj cov tshuaj kho mob.Raws li ntau cov kev tshawb fawb tseem tab tom ua, cov kws tshawb fawb tab tom nrhiav rau pem hauv ntej kom pom ntau qhov txiaj ntsig ntawm kev siv cov khoom sib xyaw no.Cov hauv qab no yog qee qhov zoo uas paub txog kev siv Stearoyl vanillylamide:
Nws zoo zom cov rog plab
Stearoyl vanillylamide ua raws li cov tshuaj capsaicin uas tuaj yeem ua rau cov nqaij adipose xim av lossis cov rog xim av (rog feem ntau pom hauv mitochondria thiab ua kom sov hauv lub cev).Cov rog muaj nyob hauv txhua qhov ntawm lub cev, suav nrog caj npab, ncej puab, plab thiab cov leeg gluteal.Txawm hais tias feem ntau cov neeg tuaj yeem tshem tawm cov rog sai sai hauv lwm qhov chaw, kev hlawv rog hauv plab yog suav tias yog lub nra tiag tiag.Cov kev tshawb fawb tau pom tias noj Stearoyl vanillylamide tuaj yeem pab zom cov rog uas tshwj xeeb nyob hauv plab.Qhov no yog ua tiav los ntawm kev ua kom TRPV1, ib qho enzyme uas tiv thaiv plab hnyuv ntau lawm thiab tsim rog.Ua ke nrog capsaicin, Stearoyl vanillylamide yog suav tias yog ib qho ntawm cov neeg ua haujlwm uas lub hom phiaj thiab qhib TRPV1 (transient receptor tej zaum vanilloid) nyob rau hauv cov plasma membrane (tshwj tsis yog cov ligands endogenous, inflammatory mediators thiab non-selective stimuli).Lub luag haujlwm rau encoding ib qho kev sib xyaw ua ke membrane protein ua ib qho ion channel.Thaum TRPV1 tshwj xeeb qhib rau ntawm cov hlwb thiab cov hlwb uas tsis yog neuronal, nws yuav ua rau cov calcium thiab sodium nkag mus, uas tsim nyog rau daim nyias nyias depolarization (polarity hloov pauv; los ntawm qhov tsis zoo mus rau qhov zoo, ua rau muaj txiaj ntsig zoo) Cell ua haujlwm thiab nws. kev sib txuas lus.
Nws zoo zom cov rog plab
Stearoyl vanillylamide ua raws li cov tshuaj capsaicin uas tuaj yeem ua rau cov nqaij adipose xim av lossis cov rog xim av (rog feem ntau pom hauv mitochondria thiab ua kom sov hauv lub cev).Cov rog muaj nyob hauv txhua qhov ntawm lub cev, suav nrog caj npab, ncej puab, plab thiab cov leeg gluteal.Txawm hais tias feem ntau cov neeg tuaj yeem tshem tawm cov rog sai sai hauv lwm qhov chaw, kev hlawv rog hauv plab yog suav tias yog lub nra tiag tiag.Cov kev tshawb fawb tau pom tias noj Stearoyl vanillylamide tuaj yeem pab zom cov rog uas tshwj xeeb nyob hauv plab.Qhov no yog ua tiav los ntawm kev ua kom TRPV1, ib qho enzyme uas tiv thaiv plab hnyuv ntau lawm thiab tsim rog.Ua ke nrog capsaicin, Stearoyl vanillylamide yog suav tias yog ib qho ntawm cov neeg ua haujlwm uas lub hom phiaj thiab qhib TRPV1 (transient receptor tej zaum vanilloid) nyob rau hauv cov plasma membrane (tshwj tsis yog cov ligands endogenous, inflammatory mediators thiab non-selective stimuli).Lub luag haujlwm rau encoding ib qho kev sib xyaw ua ke membrane protein ua ib qho ion channel.Thaum TRPV1 tshwj xeeb qhib rau ntawm cov hlwb thiab cov hlwb uas tsis yog neuronal, nws yuav ua rau cov calcium thiab sodium nkag mus, uas tsim nyog rau daim nyias nyias depolarization (polarity hloov pauv; los ntawm qhov tsis zoo mus rau qhov zoo, ua rau muaj txiaj ntsig zoo) Cell ua haujlwm thiab nws. kev sib txuas lus.
