Khoom npe:Nicotinamide riboside chloride hmoov
Lwm lub npe: 3-(Aminocarbonyl)-1-PD-ribofuranosyl-pyridinium chloride(1:1); Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vitamin NR; Niagen, TRU NIAGEN
CASNO:23111-00-4
Cov mis mos molecular: C11H15N2O5.Cl
Molecular Luj: 90.70 g / mol
Purity: 98%
Melting Point: 115 ℃ - 125 ℃
Cov tsos mob: Tawm Dawb mus rau daj ntseg daj hmoov
Siv: Boosts NAD + qib, Txhawb kev noj qab haus huv laus thiab lub hlwb / kev txawj ntse
Daim ntawv thov: raws li kev noj haus ntxiv, khoom noj khoom haus, thiab dej haus
Cov koob tshuaj pom zoo: tsis pub ntau tshaj 180 mg / hnub
Nicotinamide riboside yog ib daim ntawv txaus siab tshiab ntawm Vitamin B3, nrog cov khoom tshwj xeeb;nws yog tus thawj coj ntawm NAD +.
Nicotinamide riboside (NR), thawj zaug piav nyob rau hauv 1944 raws li ib tug loj hlob yam (Factor V) rau Haemophilus influenza, thiab nyob rau hauv 1951, NR, thawj zaug soj ntsuam raws li ib tug metabolic txoj hmoo nyob rau hauv mammalian ntaub so ntswg.
Raws li koj tuaj yeem pom tias, muaj ob hom NR muaj, ib qho yog Nicotinamide Riboside, thiab lwm yam yog Nicotinamide Riboside chloride.
Kev hais lus tshuaj, lawv yog ob qho sib txawv kiag li vim lawv muaj tus lej CAS sib txawv, NR nrog 1341-23-7 thaum NR chloride nrog 23111-00-4.NR tsis ruaj khov ntawm chav tsev kub, thaum NR chloride ruaj khov.Nto moo patented Hom npe hu ua NIAGEN®, tso tawm los ntawm Chromadex Inc nyob rau hauv 2013, yog daim ntawv ntawm Nicotinamide riboside chloride, aiming kom thim rov qab cov tsos mob ntawm kev laus hauv koj lub cev.Nicotinamide Riboside tsim los ntawm Cima Science kuj yog nyob rau hauv daim ntawv chloride hmoov.Yog tias tsis tau teev tseg, NR yuav xa mus rau NR chloride daim ntawv hauv kab lus hauv qab no.
Nicotinamide riboside cov khoom noj
Tus nqi ntawm NR hauv cov khoom noj yog feeb, piv nrog rau cov khoom noj khoom haus.Txawm li cas los xij, cov khoom noj tseem ceeb uas muaj nicotinamide riboside (NR) yog dab tsi?
nyuj nyuj
Cov mis nyuj feem ntau muaj ∼12 μmol NAD(+) cov vitamins / L, ntawm 60% tam sim no yog nicotinamide, thiab 40% yog tam sim no raws li NR.(Cov kua mis ib txwm muaj ntau NR dua li cov mis nyuj organic), kev tshawb fawb luam tawm los ntawm University of Iowa, xyoo 2016
Poov xab
Ib txoj kev tshawb fawb qub tau hais tias, "Ib qho tshuaj tiv thaiv tau raug cais tawm los ntawm cov poov xab thiab tau pom tias yog nicotinamide riboside, nws yuav muaj los ntawm NAD (P) thaum lub sij hawm npaj cov poov xab rho tawm, los yog los ntawm kev noj cov poov xab ntxiv thaum digestion hauv vivo."Thaum tsis muaj cov ntaub ntawv ntau ntawm cov poov xab
Npias
Npias muaj qhov ncaj ncees ntawm cov carbohydrates thiab haus cov dej hauv cov kua zoo li uas yuav muaj kev cuam tshuam glycemic;Ntau cov ntaub ntawv tshawb fawb tau hais tias npias yog ib qho khoom noj ntawm nicotinamide riboside.
Tsis tas li, tej zaum yuav muaj cov kab mob NR xws li whey protein, nceb, thiab lwm yam.
Rau ntau tus neeg, cov mis nyuj yog txwv tsis pub rau lwm yam laj thawj.Cov khoom noj ntawm nicotinamide riboside tej zaum yuav muaj txiaj ntsig, tab sis muaj txiaj ntsig tsawg dua li NR ntxiv.
Vim li cas Nicotinamide Riboside (NR) xaiv los ua qhov tseeb NAD + precursor vitamin invertebrates?
Muaj tsib kab ntawm kev xav txhawb nws:
Haemophilus influenza, tus kab mob ua npaws, uas tsis muaj txoj hauv kev thiab tsis tuaj yeem siv Na lossis Nam, yog nyob ntawm NR, NMN, lossis NAD + kom loj hlob hauv cov hlab ntshav.
Mis yog qhov chaw ntawm NR.
NR tiv thaiv murine DRG neurons nyob rau hauv ib qho ex vivo axonopathy assay ntawm transcriptional induction ntawm nicotinamide riboside kinase (NRK) 2 noob.
Exogenously ntxiv NR thiab derivatives nce NAD + tsub zuj zuj nyob rau hauv ib koob tshuaj-nyob ntawm seb nyob rau hauv tib neeg cell kab.
Candida glabrata, tus kab mob kis tau tus mob uas nyob ntawm NAD + cov vitamins ua ntej rau kev loj hlob, siv NR thaum kis kab mob.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (los yog nicotinic acid), yog ib qho organic compound thiab ib daim ntawv ntawm vitamin B3, ib qho tseem ceeb ntawm tib neeg cov zaub mov.Nws muaj cov mis mos C6H5NO2.
Nicotinamide los yog hu ua niacinamide yog ib daim ntawv ntawm cov vitamin B3 nyob rau hauv cov zaub mov thiab siv raws li kev noj haus thiab tshuaj.Nws muaj cov mis mos C6H6N2O.
Nicotinamide riboside yog pyridine-nucleoside daim ntawv ntawm vitamin B3 uas ua haujlwm ua tus thawj coj rau nicotinamide adenine dinucleotide lossis NAD +.Nws muaj cov mis mos C11H15N2O5+.
Nicotinamide Riboside Health Benefits
Nicotinamide Riboside pab tsim lub zog
Nyob rau hauv cov tsiaj, NR supplementation txo NAD noj, uas txhim kho mitochondrial muaj nuj nqi, ceev ceev cov leeg nqaij, thiab txuag lub zog NAD ntau ntau thiab qoj ib ce nyob rau hauv cov nas laus, pab tswj cov nqaij ntshiv thiab muaj nuj nqi, txhawb zog ntau zog.
Nicotinamide Riboside txhim kho kev txawj ntse
NR khaws cia cov paj hlwb hauv lub hlwb los ntawm kev ua kom SIRT3, Kev Pab Ntxiv txhawb nqa txoj hauv kev NAD thiab pab tiv thaiv kev degeneration hauv siab.
NR txhawb kev paub txog kev ua haujlwm thiab ua rau qeeb ntawm Alzheimer's kab mob hauv cov nas uas muab NR rau peb lub hlis.
Nicotinamide Riboside tiv thaiv tsis hnov lus
Los ntawm kev ua kom txoj hauv kev SIRT3, ib txoj kev tshawb fawb UNC pom tias nws pab tiv thaiv cov nas tsis hnov lus nrov.
Nicotinamide Riboside tiv thaiv daim siab
Noj NR qhov ncauj nce NAD hauv lub cev, uas pab tiv thaiv daim siab.NR txwv tsis pub muaj rog, txo qis oxidative kev nyuaj siab, tiv thaiv o, thiab txhim kho insulin rhiab heev hauv daim siab ntawm nas.
Tsis tas li ntawd, NR tuaj yeem ua kom lub neej ntev, Txhim kho cov metabolism, txhawb kev sib ntaus tawm tsam mob qog noj ntshav, txo cov tsos mob ntshav qab zib, nce metabolism, tuaj yeem pab txo qhov hnyav.
Puas yog Nicotinamide Riboside Safe?
Yog, NR muaj kev nyab xeeb.
NR muaj peb qhov kev sim tshuaj ntsuam xyuas tau lees tias nws muaj kev nyab xeeb rau tib neeg noj.
Ua tib zoo tshuaj xyuas thiab hais txog tag nrho cov ntaub ntawv kho mob thiab kho mob muaj nyob hauv NR kom paub tseeb tias nws muaj kev nyab xeeb thiab zam tau zoo.
Niagen muaj kev nyab xeeb thiab GRAS, siv cov txheej txheem tshawb fawb, raws li Tsoom Fwv Teb Chaws Khoom Noj, Tshuaj, thiab Tshuaj pleev ib ce (FFDCA).
Nicotinamide Riboside Kev sim tib neeg
Muaj ntau qhov kev tshawb fawb ua ntej tau ua tiav kev sim NR hauv ntau lub qauv.
Hauv 2015, thawj cov kev tshawb fawb soj ntsuam tib neeg tau ua tiav, thiab cov txiaj ntsig tau pom tias NR muaj kev nyab xeeb thiab ua tau zoo txhawb nqa qib NAD hauv cov neeg ua haujlwm pab dawb noj qab haus huv.
Kev sim tshuaj placebo ntawm nicotinamide riboside hauv cov txiv neej rog rog los ntawm randomized: kev nyab xeeb, insulin-rhiab heev, thiab cov teebmeem lipid-mobilizing
- Tshaj tawm nyob rau hauv American/Journal of Clinical Nutrition
Cov txiaj ntsig: 12 wk ntawm NR supplementation hauv koob tshuaj 2000 mg / d zoo li muaj kev nyab xeeb, tab sis tsis txhim kho insulin rhiab heev thiab tag nrho lub cev cov piam thaj metabolism hauv cov txiv neej rog rog, insulin-resistant.
Kev noj qab haus huv nicotinamide riboside tau txais txiaj ntsig zoo thiab nce NAD + hauv cov neeg laus noj qab haus huv thiab cov laus.
- Tshaj tawm hauv Nature Communications
Nicotinamide Riboside tshwj xeeb thiab Orally Bioavailable nyob rau hauv nas thiab tib neeg
- Tshaj tawm hauv Nature Communications
Ntawm no peb txhais lub sijhawm thiab koob tshuaj raws li qhov tshwm sim ntawm NR ntawm cov ntshav NAD metabolism hauv tib neeg.Daim ntawv tshaj tawm qhia tias tib neeg cov ntshav NAD tuaj yeem nce ntau npaum li 2.7-fold nrog ib koob tshuaj ntawm NR hauv kev tshawb fawb ntawm ib tus neeg thiab qhov ncauj NR nce nas kab mob siab NAD nrog pom meej thiab zoo tshaj pharm.
