Oleanolic Acid Hmoov

Oleanolic acid uas yog peb lub pentacyclic triterpenoids cais los ntawm Gentianaceae nroj tsuag ntawm Swertia mileensis tag nrho cov nyom los yog privet txiv hmab txiv ntoo, nrog ib tug dawb lub cev thiab glycosides nyob rau hauv ntau yam nroj tsuag.Oleanolic acid muaj ntau yam hauv cov nroj tsuag, thiab cov ntsiab lus nruab nrab yog 0.2% - 2%.Cov ntsiab lus siab ntawm Cucurbitaceae yog 1.5% ~ hunchback hauv qab 2%, privet txiv hmab txiv ntoo cov ntsiab lus ntawm 0.6% ~ 0.7%.Nws yog kab mob siab adjuvant thiab kho mob siv rau kev kho mob.Tus mob jaundice kab mob siab tau pom tseeb los ntawm kev txo qis alanine aminotransferase thiab yellowing.Oolic acid yog pentacyclic triterpenoids cais los ntawm cov txiv hmab txiv ntoo ntawm swertia chinensis los yog fructus ligustris los ntawm cov nroj tsuag gentianaceae.Oleanolic acid yog dav pom nyob rau hauv cov nroj tsuag, nrog rau cov ntsiab lus ntawm 0.2% ~ 2% [1].Cov ntsiab lus hauv qab ntawm calabash yog 1.5% ~ 2%, thiab cov ntsiab lus ntawm cov txiv hmab txiv ntoo ntawm fructus ligustris yog 0.6% ~ 0.7%.Oleanolic acid yog dawb acicular siv lead ua (ethanol), tsw thiab saj tsis qab.Tsis ruaj tsis khov rau acids thiab bases.Melting point ntawm 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, insoluble hauv dej, soluble hauv methanol, ethanol, ethyl ether, acetone thiab chloroform.Oleanolic acid yog ib txwm tshwm sim triterpenoid, Nyob rau hauv cov zaub mov thiab tshuaj nroj tsuag, muaj feem xyuam rau betulinic acid Nws muaj peev xwm nrhiav tau nyob rau hauv Phytolacca americana (American pokeweed), thiab Syzygium spp, qej, thiab lwm yam. Nws yog ib tug kuj tsis muaj tshuaj lom, hepatoprotective, thiab exhibits antitumor thiab antiviral zog.
Oleanolic acid tau pom los ua pov thawj muaj zog tiv thaiv kab mob HIV, cov tshuaj muaj feem xyuam nrog betulinic acid tau siv los tsim thawj cov lag luam maturation inhibitor tshuaj.Nws tau kawm thawj zaug thiab cais tawm ntawm ntau cov nroj tsuag, suav nrog Rosa woodsii (nplooj), Prosopis glandulosa (nplooj thiab twigs), Phordendron juniperinum (tag nrho cov nroj tsuag), Syzygium claviflorum (nplooj), Hyptis capitata (tag nrho cov nroj tsuag), thiab Ternstromia gymnanthera (aerial. ib feem).Lwm hom Syzygium suav nrog java kua (Syzygium samarangense) thiab cov txiv apples muaj nws.

Khoom npe: Oleanolic Acid98%

Specification: 98% los ntawm HPLC

Botanic Source: Olea Europea Extract

Lub npe tshuaj: (3β)-3-Hydroxyolean-12-en-28-oic acid

CAS Nr:508-02-1 : kuv

Qhov siv: Nplooj

Xim: Dawb hmoov nrog cov yam ntxwv tsw thiab saj

GMO Status: GMO Dawb

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

Dab tsi yogoleanolic acid?

Oleanolic acid (OA), lub ntuj hydroxyl pentacyclic triterpenoid acid (HPTA) zoo ib yam li betulinic acid, ursolic acid;Nws muaj cov txiaj ntsig zoo li tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob.

Koj tuaj yeem nrhiav tau qhov twgoleanolic acid?

Oleanolic acid tau siv ib txwm siv rau kev kho mob ntawm ntau yam kab mob, koj tuaj yeem pom nws hauv cov zaub mov thiab cov nroj tsuag dav.

Qee cov txiv hmab txiv ntoo xws li txiv apples, pomegranate, txiv qaub, bilberries, txiv ntseej muaj oleanolic acid ib yam nkaus.

Tam sim no, suav tshuaj ntsuabHemsley Chinensis cogtseem yog cov khoom lag luam tshaj plaws rau kev rho tawm oleanolic acid.

Hemsley Chinensis cog.Taw qhia

Hemsleya chinensis cogn.yog ib tsob nroj nce toj xyoob ntoo, kuj yog tshuaj suav tshuaj.

Tsev neeg: Cucurbitaceae

Tribus: Gomphogyneae

Hom: Hemsleya

Hom: H. ambilis

Cov tshuaj ntsuab tau muab faib rau hauv xeev Guangxi, Sichuan, Guizhou, Yunnan, Hubei, thiab lwm yam. Yug hauv hav zoov ntug hav zoov thiab hav zoov shrubs ntawm qhov siab txog 2,000 meters.

Cov khoom xyaw nquag: muaj Hemslolide Mal, Ma3, H1;Chikusetsusaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Cov nqi kho mob:

Hemsleya chinensis cogn.yog tsuas yog rau detoxification, sterilization, anti-inflammatory, ntxiv dag zog rau lub plab thiab txo qhov mob.Tam sim no, muaj cov hmoov rho tawm, los yog cov tshuaj sib xyaw ua ke xws li tshuaj ntsiav, ntsiav tshuaj, ntsiav tshuaj, thiab lwm yam, uas tau siv dav hauv kev kho mob.

Extraction ntawm Oleanolic acidHemsleya Chinensis cog.

Cov tshuaj muaj Oleanolic acid hauv cov khoom noj

Peb pom tias oleanolic acid siv nyob rau hauv kev noj qab haus huv tshuaj feem ntau yog los ntawm peb hom nroj tsuag extracts: Loquat nplooj extract, Hemsley Chinensis extract, thiab dawb huv basil extract.

• Dawb Basil hmoov (nplooj) (0.4% Ursolic acid thiab Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 extract (nplooj) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid thiab Oleanolic acid, 1.5 mg)
• Loquat Extract (txiv hmab txiv ntoo) (muab Ursolic acid, Oleanolic Acid) (Standardized rau Ursolic acid Ib Pab 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) thiab ursolic acid (UA) yog ntuj triterpenoids uas muaj cov qauv tshuaj zoo sib xws.

Cov triterpenoids tebchaw no paub tias muaj nyob rau hauv cov tshuaj ntsuab thiab zaub mov.

Lawv muaj ntau yam pharmacological yam ntxwv: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV kev ua, antioxidant, thiab antifertility kev ua ub no.

OA and UA:

Kev Ua Si lom neeg ntawm Oleanolic Acid

1. Anti-Tumour/Anti-Cancer Effects

Inhibitory nyhuv ntawm oleanolic acid ntawm hepatocellular carcinoma ntawm ERK-p53-mediated cell voj voog ntes thiab mitochondrial-dependent apoptosis

- los ntawm Xin Wang, Hua Bai, thiab lwm yam. Cov kws tshawb fawb

OA nthuav tawm cov nyhuv inhibitory ntawm HCC los ntawm induction ntawm apoptosis thiab cell voj voog ntes ob qho tib si hauv cov qog nqaij hlav thiab hauv HepG2 hlwb.

OA induced apoptosis los ntawm txoj kev mitochondrial, pov thawj los ntawm inhibition ntawm Akt / mammalian lub hom phiaj ntawm rapamycin txoj kev.

OA induced G2 / M cell voj voog raug ntes los ntawm p21-mediated down-regulation ntawm cyclin B1 / cdc2.

OA tau nthuav tawm cov kev ua ub no tseem ceeb hauv HCC hauv vivo thiab hauv vitro qauv.Cov ntaub ntawv no muab kev pom tshiab rau hauv cov txheej txheem hauv qab ntawm cov nyhuv antitumor ntawm OA.

Tsis tas li ntawd, kev tshawb fawb qhia tau hais tias OA thiab nws cov derivative Oleanolic acid methyl ester kuj muaj kev cuam tshuam rau mob qog noj ntshav mis, mob ntsws cancer, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog nqaij hlav pancreatic…

2. Antimicrobial Activity

OA yuav tsum muaj cov tshuaj tua kab mob tiv thaiv ntau yam kab mob rau nws ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob hauv cov nroj tsuag.

OA pom muaj kev ua haujlwm nruab nrab tiv thaiv Staphylococcus aureus thiab Bacillus Thuringiensis ntawm 62.5 µg / mL thiab Escherichia coli, Salmonella Enterica, thiab Shigella dysenteriae ntawm 31.2 µg / mL yam tsawg kawg nkaus inhibitory concentration (MIC).

3. Hepatoprotective muaj peev xwm

Ib qho tseem ceeb ntawm bioactivities ntawm OA yog kev tiv thaiv lub siab tiv thaiv toxicity thiab tam sim no yog siv raws li ib tug tshaj lub hepatic counter tshuaj nyob rau hauv Tuam Tshoj.

Hauv Wistar albino nas, OA los ntawm Flaveria Trinervia tau siv thiab muaj kev tiv thaiv tseem ceeb ntawm ethanol-induced siab toxicity los ntawm kev kho cov hepatotoxic serum marker qib enzyme.Txoj kev tshawb no qhia txog kev muaj peev xwm antioxidant ntawm OA ua lwm txoj hauv kev ntawm nws lub peev xwm hepatoprotective.

Oleanolic Acid thiab nws cov derivatives

Oleanolic Acid Clinical Trials

Oleanolic acid (los ntawm cov txiv ntseej), muaj txog 500 qhov kev sim tshuaj ntsuam xyuas, pom tias nws muaj txiaj ntsig zoo hauv kev sim tshuaj rau cov kab mob raum, mob ntshav qab zib mellitus hom 2, thiab qee yam mob xws li mob caj dab.

Feem ntau cov derivatives nrov hauv kev sim tshuaj yog bardoxolone methyl (CDDO-Me).CDDO-Me tau raug soj ntsuam hauv cov qog nqaij hlav, thiab nws yuav tuaj yeem ua lub luag haujlwm hauv kev kho mob raum kab mob, tam sim no tau raug soj ntsuam los ntawm cov teebmeem ntawm kev kub siab.

Suav Pharmacopoeia Standard ntawm Oleanolic Acid

Oleanolic acid pom zoo kom noj

Raws li Suav Pharmacopoeia Standard, Oleanolic acid Qhov ncauj koob tshuaj yog 20 ~ 80mg ib zaug, 60 ~ 240mg ib hnub twg.

Cov teebmeem ntawm Oleanolic acid

Oleanolic acid yog siv los ua ib qho tshuaj tiv thaiv kab mob (OTC) hepatoprotective rau ntau xyoo hauv Suav teb.

Yog tias siv tshuaj ntau dhau lossis tsis raug, cov neeg mob me me muaj qhov ncauj qhuav, raws plab, tsis xis nyob hauv plab, thiab tuaj yeem ploj mus tom qab kev kho mob.

Thov nrog koj tus kws kho mob lossis tus kws muag tshuaj ua ntej siv cov khoom no.

Muaj nuj nqi:

1.Oleanolic acid yog cov tsis muaj tshuaj lom, tshuaj tiv thaiv kab mob, thiab hepatoprotective, nrog rau kev nthuav tawm cov tshuaj tiv thaiv kab mob.
2.Oleanolic acid tau pom tias muaj zog tiv thaiv kab mob HIV.
3.Oleanolic acid yog ib qho tseem ceeb ntawm cov hlwb tiv thaiv oxidative thiab electrophile kev nyuaj siab.
4.Oleanolic acid muaj txiaj ntsig zoo rau kev tiv thaiv kab mob siab kab mob siab, mob icteric kab mob siab thiab kab mob siab ntev.
Daim ntawv thov:
1. Siv nyob rau hauv cov zaub mov, nws muaj peev xwm ua raws li raw cov ntaub ntawv ntawm tshuaj yej kom txo phlegm;
2. Siv rau hauv kev lag luam tshuaj, nws dhau los ua cov tshuaj tiv thaiv kab mob qog noj ntshav tshiab uas muaj tshuaj lom tsawg;
3. Siv rau hauv cov tshuaj pleev ib ce, nws tuaj yeem ua kom cov ntshav ncig thiab tshem tawm cov dej haus.