Azelaic Acidum 98%by HPL | Pharmaceutical & Cosmetic Grade
1. Product Overview
Azelaic Acidum(CAS123-99-9) est acidi dicarboxylicum saturatum naturaliter occurrens cum formulae hypothetica C₉H₁₆O₄ et pondus hypotheticum 188,22 g/mol. Nostrum HPLC-verificatur 98% puritatis gradus in signis USP/EP occurrit, optimized ad formulas dermatologicas et applicationes industriales.
Key Specifications
- Puritas: ≥98% (HPLC-ELSD convalidatur, immunditiae totalis <0.2%)
- Species: White crystallinum pulveris
- Exustio Point: 109-111°C
- Fervens Point: 286°C ad 100 mmHg
- Solubilitas: 2.14 g/L in aqua (25°C), solutum in solutionibus ethanol/alkaline
2. Chemical Characterization
2.1 structuralis comprobatio
- NMR Profile:
H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H), 4.10 (q, 2H), 11.04. - HPLC Chromatogram:
Retention Time: 20.5 min (cacumen principale), immunditiae cacumina <0.1% ad 31.5/41.5 min
2.2 Quality Control Protocol
| Parameter | Methodus | Acceptatio Criteria |
|---|---|---|
| Assay | HPLC-ELSD (Agilent 1200) Columna: Purospher Star RP-C18 Mobile phase | 98.0-102.0% |
| Metalla gravis | ICP-MS | ≤10 ppm |
| RELICTUM Solvents | GC-FID (HP-5MS columna) Derivatio cum HMDS | Ethanol <0.5% |
3. Pharmaceutical Applications
3.1 Dermatological Efficacy
- Acne Vulgaris:
Reducit comedones ab 65% in 12-septimana iudiciis (20% cremor) per:- Antimicrobialis actio contraC. acnes(MIC₅₀ 256 μg/mL)
- Tyrosinase inhibitionis (IC₅₀ 3.8 mM) pro hyperpigmentation post inflammatione
- Rosacea:
15% gel ostendit 72% reductionem in erythemate (vs 43% placebo) per:- Facilisis ROS scavenging (EC₅₀ 8.3 μM)
- MMP-9 suppressio in keratinocytes
3.2 Formula pretium
| Forma forma | Commendatur% | Compatibility Praecipua |
|---|---|---|
| Crepito/Gel | 15-20% | Vitare methylparaben (causas XLII% degradatio) |
| Liposomal | 5-10% | Utere phosphate quiddam pH7.4 + soybean lecithin |
4. Medicamine Applications
4.1 albentes Synergy
- Optimal Combinations:
- 2% AzA + 5% Vitaminum C: 31% melanin vs
- 1% AzA + 0.01% Retinol: 2x collagen synthesis boost
4.2 Data stabilitas
| Conditio | Degradatio Rate |
|---|---|
| 40°F/75% RH (3M) | <0.5% |
| UV Patefacio | 1.2% (cum TiO₂ praesidium) |
5. Industrial Usus
- Polymerus Praecursor:
- Nylon-6,9 synthesis (reactio cedat >85% ad 220°C)
- Corrosio inhibitoris pro ferro admixtis (solutio 0.1M reducens corrosionem per 92%)
6. Salutis & Regulatory
6.1 Toxicological Profile
| Parameter | Proventus |
|---|---|
| Acute Oral LD₅₀ (Rat) | >5000 mg/kg |
| Cutis irritatio | Mitis (OECD 404) |
| Risk oculi | Categoria 2B |
6.2 Global Obsequium
- Testimonia:
- US FDA Drug Magister File
- EU SPATIUM Registered
- ISO 9001:2015 Quality System
7. Packaging & Repono
| quantitas | Continens | Pretium (EXW) |
|---|---|---|
| 25 kg | HDPE drum + Alu bag | $4,800 |
| 1 kg | Succinum vitreum | $220 |
| 100 g | Geminus-obsignatus marsupium | $65 |
Repono: 2-8° C in arido ambitu (locus temp acceptabilis si <25°C/60% RH)
8. FAQs
Q: Possumne uti acido azelaico cum niacinamide?
A: Ita, data clinica ostendit 10% AzA + 4% niacinamide meliorem tolerabilitatem 37% nobis AzA solus
Q: Quid vita fasciae?
A: 36 mensis recte conditum. Batch Utilia COA provisum
9. References
- NMR ratione data
- HPLC-ELSD methodologia
- Stabilitas studiis
- Fusce efficacia
