Product Name: Tranexamic Acidum XCVIII% ab HPLC
CAS No.:1197-18-8
Formulae hypotheticae: C₈H₁₅NO₂
Pondus hypotheticum: 157.21 g/mol
Puritas: ≥98% (HPLC)
Species: White crystallinum pulveris
Repono: +4°C (brevis-terminus), -20°C (long-terminus)
Applicatio: Pharmaceutical, Cosmetica, Research
1. Product Overview
Acidum tranexicum (TXA), lysinum analogicum syntheticum, late pro agente antifibrinolytico ad sanguinem reducendum in uncinis chirurgicis et trauma. Productum hoc sub stricto quali- tatis potestate conficitur, ut puritatem ≥98% prospiciat per Maximum euismod Liquid Chromatographia (HPLC). Eius structura chemica (trans-4-(aminomethyl)acidi cyclohexanecarboxylici) et alta stabilitas eam aptam facit diversis applicationibus, inter quas:
- Medicinae usus: Hemorrhage imperium, cerebrum traumaticum laesio (TBI) curatio.
- Medicamina: Cutis albae crepito nisi hyperpigmentation.
- Investigatio: Methodus analytica evolutionis et studia pharmacokinetica.
2. Chemical et Physica
- Nomen IUPAC: 4-(Aminomethyl) acidum cyclohexanum-1-carboxylicum
- SMILES: NC[C@@H]1CCC@HC(=O)O
- InChI Key: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Liquefactio Point: 386°C (dec.)
- Solubilitas: Solubilis in aqua (1N HCl, pH-buffis accommodata), methanolum, et acetonitrilum.
3. Quality Assurance
3.1 HPLC Analysis
Methodus nostra HPLC accuratam quantitatem et immunditiam profilingit;
- Columna: XBridge C18 (4.6 mm × 250 mm, 5 µm) vel aequivalens.
- Mobile Phase: Methanol: acetatis quiddam (20 mM, pH 4) (75:25 v/v).
- Fluunt Rate: 0.8–0.9 mL/min.
- Deprehensio: UV ad 220 um vel 570 um (post derivationem cum 1% ninhydrin).
- Systema Opportunitas:
- Subtilitas: ≤2% CV ad apicem areae (6 replicat).
- Recuperatio: 98-102% (80%, 100%, 120% gradus spicati).
3.2 immunditia Profile
- Immunditia A: ≤0.1%.
- Immunditia B: ≤0.2%.
- Totalis immunditias: ≤0.2%.
- Halides (as Cl⁻): ≤140 ppm.
3.3 Stability
- pH Stabilitas: Compatibilis cum buffers (pH 2-7.4) et communibus IV solutionibus (eg, fructoso, chloridi natrii).
- Stabilitas scelerisque: Stabilis ad 37°C per 24 horas in matricibus biologicis.
4. Applications
4.1 Medical Usus
- Trauma Cura: mortalitatem in TBI aegros per 20% reducit (CRASH-3 iudicium).
- Surgery: Minimizes perioperative sanguinis iactura (orthopaedica, cardiac surgeries).
4.2 Cosmetics
- Mechanismus: Inhibet plasmin-melanogenesis effecerunt claudendo sites lysine-bingendi.
- Formulae: 3% TXA crepito pro melasma et hyperpigmentatione.
- Salus: Topical usus systemica vitat pericula (eg, thrombosis).
4.3 Research & Development
- Methodi analytici: Synthesis: Prodrug studiorum interconversionis sub conditionibus acidicis.
- UPLC-MS/MS: Ad plasma analysis (LOD: 0.1 ppm).
- Fluorimetry: Derivatio cum NDA/CN (5-minute reactio).
5. Packaging & Repono
- Primary packaging: Signati aluminium saccis desiccant.
- Shelf Life: 24 months at -20°C.
- Shipping: Ambiens temperatus (valided for 72 hours).
6. Salus et Obsequium
- Tractatio: Usus PPE (glostus, goggles) ad vitandum inhalationem / contactum.
- Status regularis: Complies cum USP, EP et JP pharmacopeias.
- Toxicity: LD₅₀ (oral, rat) >5,000 mg/kg; non-carcinogenic.
7. References
- Ratio congruentia sanatio pro HPLC.
- Calibratio curvae et protocolla derivationis.
- UPLC-MS/MS comparationis methodus.
- Pretium efficaciae in trauma cura.
- Formula medicaminis firmitatis.
Keywords: Acidum tranexicum 98% HPLC, Agens Antifibrinolytic, Cutis dealbatio, Trauma Cura, UPLC-MS/MS, CONLISUS 3 Tentatio, Melasma Curatio
Meta Description: Acidula Tranexamica (≥98% ab HPLC) ad medicinae, medicamen, et inquisitionis usum. Modi validae HPLC, cura trauma cost-efficax, et formulae topicae tutae. CAS 1197-18-8.
