Ingoa Hua:Celastrol puranga paura
Puna Botanic:Te Atua Vine(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Tae: Te paura karaihe karaka whero me te kakara me te reka
Whakatakotoranga:≥98% HPLC
GMOTūnga:GMO Free
Tapeke: i roto i te 25kgs pahū muka
Rokiroki: Puritia te ipu kia kore e tuwhera ki te waahi makariri, maroke, mawehe atu i te marama kaha
Te Ora: 24 marama mai i te ra o te whakaputanga
Paura CelastrolKo te whakauru kaha i roto i te Tripterygii Radix, ko te pakiaka maroke me te rhizome o te Atua Vine.E wha nga momo katoa, araTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, me Tripterygium forresti Dicls.
Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide(cas no.38647-10-8), etc.
Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), etc.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, etc.
Ko te Tripterygium he pentazine triterpene ka kitea i roto i te Tripterygium wilfordii.He whai hua ki te rongoa i te mate rheumatoid arthritis.Ko te Triptolide te aukati i te mahi proteasome me te tauwehe karihi Kb.
Ko te Celastrol (Tripterin) he aukati proteasome me nga mahi anti-inflammatory me te antioxidant.He pai, he pai te aukati i te mahi chymotrypsin-rite o te 20S proteasome me te IC50 o te 2.5 μM.
Ko te Tripterine he antioxidant kaha me te kaihoko anti-inflammatory.He aukati HSP90 hou (he whakararu i te matatini Hsp90/Cdc37), he hua anti-mate pukupuku (anti-angiogenesis - ka aukati i te whakahuatanga o te kaiwhakawhiwhi tohu endothelial endothelial vascular);antioxidant (ka aukati i te lipid peroxidation) me te mahi anti-inflammatory (Ka aukati i te hanga iNOS me nga cytokine inflammatory)
BiologicalAmahi:
Ko te Celastrol (Tripterin) ka whakaheke-whakahaere i te monoubiquitination FANCD2, i muri mai i te whakahekenga pūmua.Ka whakakorehia e te maimoatanga Celastrol te waahi arowhai G2 a IR me te whakarei ake i te kino o te DNA na te tarukino-whakaawe i te ICL me nga paanga aukati ki nga pūtau mate pukupuku pūkahukahu ma te whakakore i te FANCD2.He nui nga paanga aukati me te apoptosis-whakaawe a Celastrol i runga i nga pūtau DU145 i whakatipuhia i roto i te vitro i roto i te waa-me te horopeta-whakaaro.Ko te awenga mate pukupuku anti-prostate a Celastrol he wahanga na roto i te whakaheke-whakahaere i te taumata whakapuaki o nga hongere hERG i roto i nga ruma DU145, e kii ana tera pea ko Celastrol he rongoa mate pukupuku mate pukupuku, a ko tana tikanga he aukati i nga hongere hERG.Ka whakapai ake a Celastrol i te colitis whakamatautau i roto i nga kiore IL-10-kore ma te aukati i te ara tohu tohu PI3K/Akt/mTOR me te whakatikatika i te autophagy.Kei a Celastrol te kaha ki te aukati i te mahi cytochrome P450, a tera pea ka puta nga taunekeneke otaota.Ko te Celastrol te whakauru i te apoptosis i roto i nga pūtau TNBC, e kii ana ka taea te takawaenga i te apoptosis na roto i te koretake o te mitochondrial me te ara tohu tohu PI3K/Akt.Ko te Celastrol te whakauru i te apoptosis me te autophagy i roto i te huarahi tohu ROS / JNK.Ka aukati a Celastrol i te mate neuron dopaminergic i te mate o Parkinson ma te whakahohe i te apoptosis mitochondrial.
Te mahi a Celastrol i te chemosensitization mate pukupuku:
Ka noho tonu te chemotherapy hei huarahi maimoatanga matua mo nga turoro mate pukupuku.Engari, me hono tonu te chemotherapy ki etahi atu raau taero hei whakaiti i nga paanga kino me te karo i te aukati tarukino.Kei te kaha haere nga hua maori hei rongoa awhina i te taha o nga tikanga chemotherapy o naianei hei whakarei ake i te kaha o te maimoatanga.Ko tetahi tauira pai o taua rongoa maori ko te puhui triterpene e kiia nei ko te celastrol, tera pea ka kaha te whakamahi hei whakamaarama matū.I tautuhia i te tuatahi mai i te Thunder God Vine, ka whakahaere kino i nga ngota oncogenic maha penei i te NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, me Notch-1.Ka taea e enei te arahi ki te urupare anti-inflammatory, te aukati i te tipu o te pukupuku me te oranga, me te whakakore i te angiogenesis.Ka whakapotohia e tenei upoko te mahi pea a te celastrol hei kaiwhakaora chemosensitizer me nga tikanga ngota i raro i te takawaenga i ona paanga chemosensitizing kua korerotia i roto i nga momo mate pukupuku.
