Azelaic acid 98%e HPLC | Vasega Fa'afoma'i & Teuga
1. Va'aiga lautele o oloa
Azelaic Acid(CAS123-99-9) o se mea fa'anatura fa'atupula'ia le dicarboxylic acid fa'atasi ai ma le fua mole mole C₉H₁₆O₄ ma le mamafa mole 188.22 g/mol. O la matou HPLC-faʻamaonia 98% mama togi faʻafeiloaʻi USP / EP tulaga faʻataʻitaʻiga, sili ona lelei mo faʻamaʻi faʻamaʻi ma faʻaoga faʻapisinisi.
Fa'amatalaga autu
- Mama: ≥98% (HPLC-ELSD faʻamaonia, faʻaleagaina atoa <0.2%)
- Fa'aaliga: Pa'epa'e tioata pa'epa'e
- Lisi Lisi: 109-111°C
- Fa'apuna: 286°C ile 100 mmHg
- Solubility: 2.14 g/L ile vai (25°C), solu i vaifofo ethanol/alkali
2. Fa'ata'ita'iga o vaila'au
2.1 Fa'amaumauga Fa'atonu
- NMR Tala'aga:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H ta‘itasi), 4.20 (t, 2H ta‘itasi), 4.20 (t, 2H ta‘itasi), 4.10 COOH) - HPLC Chromatogram:
Taimi Taofi: 20.5 min (tulaga autu), maualuga le mama <0.1% ile 31.5/41.5 min
2.2 Polokalama Pulea Lelei
| Parameter | Metotia | Ta'iala Talia |
|---|---|---|
| Su'ega | HPLC-ELSD (Agilent 1200) Koluma: Purospher Star RP-C18 Vaega Feavea'i: Methanol/Water/Acetic Acid gradient | 98.0-102.0% |
| Metala mamafa | ICP-MS | ≤10 ppm |
| Solvents totoe | GC-FID (koluma HP-5MS) Derivatization ma le HMDS | Ethanol <0.5% |
3. Talosaga Fa'afoma'i
3.1 Lelei Fa'ama'i
- Acne Vulgaris:
Fa'aitiitia comedones i le 65% ile 12-vaiaso su'ega (20% kulimi) e ala ile:- Antimicrobial gaioiga faasagaC. acnes(MIC₅₀ 256 μg/mL)
- Tyrosinase inhibition (IC₅₀ 3.8 mM) mo le hyperpigmentation post-inflammatory
- Rosacea:
15% gel o loʻo faʻaalia ai le 72% faʻaititia o le erythema (vs 43% placebo) e ala i:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- MMP-9 taofiofia i keratinocytes
3.2 Ta'iala Fa'atulagaina
| Fua Fa'atatau | Fautuaina % | Fa'amatalaga Fegalegaleai |
|---|---|---|
| kulimi/Keli | 15-20% | Aloese mai le methylparaben (e mafua ai le 42% faʻaleagaina) |
| Liposomal | 5-10% | Fa'aaoga le phosphate buffer pH7.4 + soya lecithin |
4. Talosaga Teuga
4.1 Whitening Synergy
- Fa'atasiga sili ona lelei:
- 2% AzA + 5% Vitamini C: 31% melanin fa'aitiitia vs monotherapy
- 1% AzA + 0.01% Retinol: 2x collagen fa'atupu fa'atuputeleina
4.2 Fa'amaumauga mautu
| Tulaga | Fua Fa'aleagaina |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Fa'aaliga UV | 1.2% (ma le puipuiga o le TiO₂) |
5. Fa'aaogāga Alamanuia
- Polymer Precursor:
- Nylon-6,9 fa'atupuina (ga'i gaioi> 85% i le 220°C)
- Iniseti fa'ama'i mo u'amea u'amea (0.1M fofo fa'aitiitia ai le a'a e 92%)
6. Saogalemu & Tulafono Faatonutonu
6.1 Fa'amatalaga Toxicological
| Parameter | I'uga |
|---|---|
| Tu'ugutu Mata'utia LD₅₀ (Iole) | >5000 mg/kg |
| Fa'aita'i le Pa'u | Malu (OECD 404) |
| Tulaga Mata'utia | Vaega 2B |
6.2 Tausisia i le lalolagi atoa
- Tusipasi:
- US FDA Drug Master File
- EU REACH Resitala
- ISO 9001:2015 Faiga Tulaga Lelei
7. afifiina & Teuina
| Tele | Containe | Tau (EXW) |
|---|---|---|
| 25 kilokalama | HDPE pa'u + Alu taga | $4,800 |
| 1 kilokalama | Amber fagu tioata | $220 |
| 100 g | Taga fa'amaufa'alua | $65 |
Teuina: 2-8°C i le si'osi'omaga mago (te vevela potu e talia pe a <25°C/60% RH)
8. FAQ
Q: E mafai ona ou fa'aogaina le azelaic acid ma le niacinamide?
A: Ioe, o faʻamatalaga faʻapitoa e faʻaalia ai le 10% AzA + 4% niacinamide faʻaleleia le gafatia 37% vs AzA naʻo ia
Q: O le a le ola fa'asa?
A: 36 masina pe a teuina lelei. COA fa'apitoa tu'ufa'atasi ua tu'uina atu
9. Fa'amatalaga
- NMR fa'amatalaga fa'amatalaga
- HPLC-ELSD metotia
- Suesuega mautu
- Lelei fa'afoma'i
