Igoa Oloa: Tranexamic Acid 98% e HPLC
Numera CAS:1197-18-8
Fuafua mole: C₈H₁₅NO₂
Malosi mole: 157.21 g/mol
Mama: ≥98% (HPLC)
Fa'aaliga: Pa'epa'e tioata pa'epa'e
Teuina: +4°C (puupuu), -20°C (umi)
Talosaga: Pharmaceutical, Cosmetics, Research
1. Va'aiga lautele o oloa
Tranexamic Acid (TXA), o se synthetic lysine analog, e masani ona faʻaaogaina e fai ma sui o le antifibrinolytic e faʻaitiitia ai le toto ile taotoga ma faʻalavelave faʻalavelave. O lenei oloa o loʻo gaosia i lalo o le faʻatonuga lelei, faʻamautinoa le mama o le ≥98% e pei ona faʻamaonia e le High-Performance Liquid Chromatography (HPLC). O lona fausaga kemikolo (trans-4-(aminomethyl)cyclohexanecarboxylic acid) ma le mautu maualuga e talafeagai mo le tele o talosaga, e aofia ai:
- Fa'aaogāga Fa'afoma'i: Puleaina o le toto, manu'a manu'a fa'ama'i (TBI).
- Mea teuteu: kulimi pa'epa'e pa'u e fa'atatau i le hyperpigmentation.
- Su'esu'ega: Su'esu'ega o metotia su'esu'e ma su'esu'ega pharmacokinetic.
2. Kemisi ma Meatotino Faaletino
- IUPAC Igoa: 4-(Aminomethyl)cyclohexane-1-carboxylic acid
- 'ATA'ATA: NC[C@@H]1CCC@HC(=O)O
- InChI Ki: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Lisi Lisi: 386°C (tes.)
- Solubility: Solu i le vai (1N HCl, pH-fetuunai pa'u), methanol, ma acetonitrile.
3. Fa'amautinoaga Tulaga
3.1 Su'esu'ega HPLC
O la matou HPLC auala e faʻamautinoa ai le faʻamaonia saʻo ma le faʻaleagaina:
- Koluma: XBridge C18 (4.6 mm × 250 mm, 5 μm) pe tutusa.
- Vaega Feavea'i: Methanol:acetate pa'u (20 mM, pH 4) (75:25 v/v).
- Fua o le tafe: 0.8–0.9 mL/min.
- Su'esu'ega: UV ile 220nm po'o le 570nm (post-derivatization ma le 1% ninhydrin).
- Faiga talafeagai:
- Sa'o: ≤2% CV mo vaega pito i luga (6 kopi).
- Toe fa'aleleia: 98–102% (80%, 100%, 120% maualuga maualuga).
3.2 Fa'amatalaga Le mama
- Le mama A: ≤0.1%.
- Le mama B: ≤0.2%.
- Aofa'i Fa'aleaga: ≤0.2%.
- Halides (pei o Cl⁻): ≤140 ppm.
3.3 Mausali
- pH Fa'amautu: E fetaui ma pa'u (pH 2–7.4) ma vaifofo masani IV (fa'ata'ita'iga, fructose, sodium chloride).
- Mauaina o le vevela: Fa'amau i le 37°C mo le 24 itula i matrices biological.
4. Talosaga
4.1 Fa'aaogāga Fa'afoma'i
- Tausiga Faʻaleagaina: Faʻaititia le oti i tagata maʻi TBI e 20% (CRASH-3 trial).
- Ta'otoga: Fa'aiti'itia le toto ma'imau (tootope fa'ama'i, ta'otoga fatu).
4.2 Mea teuteu
- Mechanism: Taofi le plasmin-induced melanogenesis e ala i le polokaina o nofoaga e fusifusia ai le lysine.
- Fuafuaga: 3% TXA kulimi mo melasma ma hyperpigmentation.
- Saogalemu: O le fa'aogaina i luga ole laiga e 'alofia ai fa'alavelave fa'apitoa (fa'ata'ita'iga, thrombosis).
4.3 Suesuega & Atinae
- Metotia Su'esu'e: Fa'asologa: Prodrug interconversion su'esu'ega i lalo ole tulaga oona.
- UPLC-MS/MS: Mo su'esu'ega plasma (LOD: 0.1 ppm).
- Fluorimetry: Fa'atupuina ma le NDA/CN (5-minute tali).
5. Fa'apipi'i & Teuina
- Fa'apipi'i Tulaga Muamua: ato alumini fa'amau fa'atasi ma fa'amago.
- Ola Fa'asa: 24 masina ile -20°C.
- Va'a: Ambient vevela (fa'amaonia mo le 72 itula).
6. Saogalemu ma Tausi
- Taulimaina: Fa'aaoga PPE (totini lima, mata tioata) e 'alofia ai le manava/fa'afeso'ota'i.
- Tulaga Fa'atonutonu: Fa'amalieina USP, EP, ma JP pharmacopeias.
- Oona: LD₅₀ (tugutu, isumu) >5,000 mg/kg; e le fa'amasani.
7. Fa'asinomaga
- Fa'amaoniaga talafeagai mo le HPLC.
- Calibration curve ma fa'asologa o fa'asologa.
- UPLC-MS/MS auala fa'atusatusaga.
- Tau-lelei ile tausiga o manu'a.
- Fa'amautu mea teuteu.
upu autu: Tranexamic Acid 98% HPLC, Antifibrinolytic Agent, Paʻu Paʻu, Tausiga Faʻaleagaina, UPLC-MS / MS, CRASH-3 Trial, Melasma Togafitiga
Fa'amatalaga Meta: Acid Tranexamic Acid maualuga-mama (≥98% e le HPLC) mo fa'afoma'i, teuteuga, ma su'esu'ega fa'aoga. Metotia HPLC fa'amaonia, tausiga o manu'a taugofie, ma fa'atūlaga saogalemu. CAS 1197-18-8.
