Igoa o oloa:CMS121
Isi Igoa:CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzymeACarboxylase,fa'ama'i,neuroprotective,fa'a'afia,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121
NO. CAS:1353224-53-9
Su'ega: 98.0% Min
Lanu: pa'u samasama mama
afifiina: 25kg/DRUMS
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol o se tuufaatasiga e taua foi CMS121. O le lavelave o le fausaga o le tuufaatasiga ua ta'u mai ai e ono iai ni mea uiga ese ma ni mea e mafai ona faaaoga. Ina ia malamalama i lona taua, e fesoasoani e faʻailoa vaega faʻatino o loʻo i ai ma auʻiliʻili a latou aʻafiaga
CMS121 o se quin oline suitulaga lea ei ai neuroprotective, anti-inflammatory, antioxidative, ma renoprotective gaoioiga. O loʻo faʻatumauina le maualuga o le glutathione (GSH) i le HT22 mouse hippocampal cell in vitro i le i ai o le glutamate, faʻaosofia le eseesega o sela PC12, puipuia le LPS-induced N9 microglial activation e 82% i le N9 microglia, ma faʻasalaina radical free i totonu o le Trolox e tutusa le gaioiga gaioiga. (TEAC) su'esu'ega. CMS121 puipuia mai ischemia ma oxytosis i phenotypic screens i sela HT22 in vitro ma EC50 tau o le 7 ma le 200 nM mo le puipuia o le iodoacetic acid-poʻo le glutamate-induced cell death, faasologa. E toe puipuia foi, faʻaitiitia le mamafa o fatugaʻo ma faʻaitiitia le faʻaalia o le TNF-α, caspase-1, ma le inducible nit ric oxi de synthase (iNOS) i se faʻataʻitaʻiga SAMP8 o le faʻamaʻi fatugaʻo tumau e fesoʻotaʻi ma le matua vave pe a faʻatonuina i se tui. ole 10 mg/kg ile aso e amata ile iva masina ole matua.
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol o se tuufaatasiga e taua foi CMS121. O le lavelave o le fausaga o le tuufaatasiga ua ta'u mai ai e ono iai ni mea uiga ese ma ni mea e mafai ona faaaoga. Ina ia malamalama i lona taua, e fesoasoani e faʻailoa vaega faʻatino o loʻo i ai ma auʻiliʻili a latou aʻafiaga. O le i ai o le mama quinoline e taʻu mai ai e mafai e le faʻapipiʻi ona ola faʻapitoa. O molelaʻau e maua mai i le Quinoline e lauiloa mo a latou mea ola ola eseese, e aofia ai gaioiga faʻamaʻi ma anti-inflammatory. O le fa'apipi'iina o le vaega o le cyclopentyloxy e mafai ona saofagā i le solubility o le pa'u po'o le fa'aleleia atili o ana gaioioiga olaola e ala i a'afiaga. I suʻesuʻega i luga o sela HT22, CMS-121 ua faʻaalia ai aʻafiaga taua o le neuroprotective, puipuia lelei nei sela mai le ischemia ma le faʻaleagaina o le oxidative. E le gata i lea, o le CMS-121 o loʻo i ai ni mea taua e teteʻe ai i le faʻamaʻi, e faʻaalia ai lona gafatia e faʻafetaui tali faʻafefe. I le faia o lea mea, o le CMS-121 e mafai ona faʻaitiitia ai le mumū i totonu o aʻu ma totoga eseese. CMS-121 o loʻo i ai le malosi faʻafomaʻi gaioiga e avea o se faʻalavelave ole acetyl-CoA carboxylase 1 (ACC1). O lona a'afiaga malosi i luga o le ACC1 ua avea ai ma fa'alapotopotoga fa'amoemoe
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