Igoa o oloa:YDL223C (HBT1) Pa'u

Isi Igoa:HBT1,YDL223C

CASNo:489408-02-8

Fa'amatalaga:99.0%

Lanu:Malosi samasama malamalamama uiga manogi ma le tofo

GMOTulaga: GMO Free

afifiina: i 25kgs fibre talipalau

Teuina: Taofi le atigipusa e le tatalaina i se nofoaga malulu, matutu, Taofi ese mai le malamalama malosi

Ola Faʻamau: 24 masina mai le aso na gaosia ai

O le HBT1 o se mole e mafai ona fusifusia i se nofoaga patino i luga o le AMPA-R protein pe a iai le glutamate, ma o lenei fusi e fesoasoani e faʻatonutonu le gaioiga o le porotini. AMPA faʻafeiloaʻi o loʻo faʻaalia i totonu o le fatugalemu o le tino ma taʻalo taua i fesoʻotaʻiga neuronal, gaioiga faʻalogo, aʻoaʻoga, manatua, ma le synaptic plasticity. O talitali a le AMPA e tele sao i le neurotransmission faʻamalosi, faʻasalalau vave, faʻavaveina le faʻafefe i le tele o synapses, ma o loʻo aʻafia i vave tali i le glutamate i le synaptic regions. AMPA faʻafeiloaʻi e masani ona faʻaalia faʻatasi ma NMDA faʻafeiloaʻi i synapses, ma faʻatasi latou te faʻalauteleina faiga faʻapipiʻi synaptic e aofia i le aʻoaʻoina, manatua, excitotoxicity, ma le neuroprotection. O le mea e maua mai i le faiʻai o le neurotrophic factor (BDNF) o se vaega neurotrophic e taua tele i le tausiga ma le faʻalauteleina o neu ma e iai le malosi ma le tele o aʻafiaga i luga o le faʻateleina, faʻavasegaina, ola ma le oti o sela neuronal ma non-neuronal. , o se neurotransmitter modulator e fesoasoani i le palasitika neuronal i le aʻoaʻoina ma le manatua. O le mea lea, e taua mo le soifua maloloina ma le soifua manuia o le tino.

Galuega:

1. Fa'afefete genomic knockout fa'afefe
   2. Shmoo pito polotini, substrate o Hub1p ubiquitin-pei polotini; mutants e le atoatoa mo le faia o faʻataʻitaʻiga, o lea
   fa'aaafiaina le Hbt1p ile polarized cell morphogenesis; HBT1 ei ai se paralog, YNL195C, na aliaʻe mai le faʻasologa atoa o le genome
   3. Faʻaaogaina i vailaʻau faʻamaʻi.
   4. Faaleleia le atamai faalemafaufau.
   5. Fa'ateleina le manatua ma le fa'alagolago.
   6. Faʻaleleia tulaga faʻaosofia.
   7. Faʻaleleia le faʻaogaina o le faiʻai o le cortical / subcortical.
   8. Faʻaleleia le faʻaogaina o lagona.
   9. Faʻaleleia le malosi ole faiʻai e foia ai faʻafitauli ma puipuia mai soʻo se vailaʻau poʻo le tino.

Talosaga:

O le HBT1 o se tala malosi AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator e maualalo le agonistic aʻafiaga faʻatusatusa i le LY451395 ma OXP1, e faʻaosofia ai le gaosiga o le faiʻai e maua mai. neurotrophic factor (BDNF) ma faʻaalia sina aʻafiaga faʻaleagaina i neu muamua. HBT1 e fusifusia i le ligand-binding domain o le AMPA-R i le glutamate dependent manner